Cluster Scientists Discover New Role of CCL17

September 12, 2018

From left: Nina Offermann, Lorenz Fülle und Prof. Dr. Irmgard Förster. © Foto: Barbara Frommann/Uni Bonn

Top: CCL17-producing neurons (green) and microglia (red) in the hippocampus. Bottom: Reconstruction of an individual microglia cell from wild-type or CCL17-knockout mice. Credit: Lorenz Fülle/Uni Bonn

 

ImmunoSensation Cluster scientists and associated members discover a new role for the allergy driver: It influences signal transmission in the brain

 

The chemotactic protein CCL17 attracts immune cells to where they are currently needed. Doctors have long known: A high level of this substance in the body indicates an allergic reaction. A team of scientists led by the University of Bonn has now discovered a completely new function: CCL17 also influences signal transmission in the brain. There may even be a molecular link to autism. The results have now been published in the journal “GLIA”.

The article which they published in Glia is available online DOI: 10.1002/glia.23507
The press release is available here