Prof. Förster and colleagues published in Molecular Therapy

November 03, 2017

Prof. Dr. Irmgard Förster (right) and Prof Dr. Günter Mayer (left) together with their team generated an aptamer, which inhibits contact allergy in mice. The machine in the back is a so-called aptamer roboter that is able to select aptamers in an automated process. Photo: Volker Lannert/Uni Bonn

 

Researchers from the University of Bonn have isolated a molecule that is suitable for the control of contact allergies. The study illuminates a central immune mechanism, which may also play a role in other inflammatory diseases such as arthritis or arteriosclerosis. The results will soon be published in the journal Molecular Therapy, but are already available online.

Last author Irmgard Förster is a member of the Cluster of Excellence ImmunoSensation and a Professor of the LIMES Institute Bonn.

 

Find the german press release here and the english press release here.

 

Publication: Lorenz Fülle, Nancy Steiner, Markus Funke, Fabian Gondorf, Franziska Pfeiffer, Julia Siegl, Friederike V. Opitz, Silvana Haßel, Anna Belen Erazo, Oliver Schanz, H. James Stunden, Michael Blank, Carsten Gröber, Kristian Händler, Marc Beyer, Heike Weighardt, Eicke Latz, Joachim L. Schultze, Günter Mayer und Irmgard Förster: RNA aptamers recognizing murine CCL17 inhibit T cell chemotaxis and reduce contact hypersensitivity in vivo; Molecular Therapy; DOI: 10.1016/j.ymthe.2017.10.005