Science Publication: Where do immune cells come from?

May 05, 2017

Prof. Dr. Joachim Schultze, Patrick Günther and Dr. Andreas Schlitzer from LIMES-Institute at University of Bonn. © Photo: Volker Lannert/Uni Bonn

 

Congratulation to Cluster member Dr. Andreas Schlitzer, PD Dr. Marc Beyer and Prof. Dr. Joachim L. Schultze from the LIMES Institute Bonn. They recently published their newest findings about dendritic cell progenitors in Science.

Dendritic cells are gatekeepers of Immunity and are crucial for the detection and initiation of Immunity against pathogens and foreign substances. Up to now dendritic cell subtypes were thought to develop from one common progenitor. Now, in a joint effort, researchers from A*STAR Singapore Immunology Network, LIMES-Institute and cluster of excellence ImmunoSensation from University of Bonn and the German Center for Neurodegenerative Diseases were able to show with single cell resolution that this important component of the human immune system develops from specialized progenitors. These findings are now published in “Science” and have implications for the development and optimization of vaccines.

Publication: Mapping the human DC lineage through the integration of high-dimensional techniques, Science, DOI: 10.1126/science.aag3009

Find the german press release here and the english press release here.