ImmunoSensation - the immune sensory system

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Life Sci. 2018 Dec 4.

CB2-deficiency is associated with a stronger hypertrophy and remodeling of the right ventricle in a murine model of left pulmonary artery occlusion.

Duerr GD, Feißt A, Halbach K, Verfuerth L, Gestrich C, Wenzel D, Zimmer A, Breuer J, Dewald O

Pulmonary hypertension (PH) leads to right ventricular (RV) adaptation and remodeling and has deleterious long-term effects on RV function. The endocannabinoid receptor CB2 has been associated with protective effects in adaptation and remodeling of the left ventricle after ischemia. Therefore, we investigated the role of CB2 receptor in RV adaptation after occlusion of the left pulmonary artery (LPA) in a murine model.

PMID: 30403990