ImmunoSensation - the immune sensory system

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Neurogastroenterol Motil. 2018 Dec 8.

Non-invasive transcutaneous auricular vagus nerve stimulation prevents postoperative ileus and endotoxemia in mice.

Hong GS, Zillekens A, Schneiker B, Pantelis D, de Jonge W, Schaefer N, Kalff JC, Wehner S

The cholinergic anti-inflammatory pathway comprises the perception of peripheral inflammation by afferent sensory neurons and reflex activation of efferent vagus nerve activity to regulate inflammation. Activation of this pathway was shown to reduce the inflammatory response and improve outcome of postoperative ileus (POI) and sepsis in rodents. Herein, we tested if a non-invasive auricular electrical transcutaneous vagus nerve stimulation (tVNS) affects inflammation in models of POI or endotoxemia.

PMID: 30406957