immunorecognition of nucleic acids, lectins and dendritic cells, local immune regulation in the liver and the gut, immune cell migration, the endocannabinoid system and the crossroad of metabolism and innate immunity. It is now evident that immune sensing is involved in many of the lifestyle-associated diseases of modern societies, such as atherosclerosis, metabolic syndrome and diabetes, neurodegeneration and cancer. The University of Bonn and participating institutions are uniquely situated to address the challenges and the great potential of this emerging field. Three institutes in the Medical Faculty and two units at LIMES are exclusively devoted to immunology. In 2009, the state NRW awarded the University of Bonn with research funds for the establishment of the first Institute of Innate Immunity in Germany. The recruitment of additional scientists and the establishment of cross-institutional technological platforms will catalyze our efforts to better understand immune sensing receptors and their ligands, their regulation by the local and systemic environments, and the integration of sensory input and its consequences for inflammation in vivo. The International Innate Immunity Consortium (IIIC) is a great asset to our international collaborations. Together with its strong measures for early career support and gender equality, the ImmunoSensation Cluster of Excellence stands well prepared to become one of the leading centers of innate immune sensing and ultimately to make a sustained impact on human health. Achievements of the group.