Institute of Clinical Chemistry & Clinical Pharmacology
Medical Faculty, University of Bonn
University Hospital of Bonn
The Barchet group focuses on the innate immune sensing of nucleic acids in scenarios ranging from pathogen infection, to cellular distress and autoinflammation. We study how and when distinct immune active structures are generated, gain access to receptors and are disposed of; and what mechanisms regulate the sensitivity of nucleic acid sensing pathways in sentinel cell-types, with the ultimate goal of informing appropriate immune therapeutic interventions.