Speaker, Steering committee-member, Member
Institute of Clinical Chemistry & Clinical Pharmacology
Medical Faculty, University of Bonn
University Hospital of Bonn
For over 20 years, Prof Hartmann’s research focus has been nucleic acid sensing in the broader context of nucleic acid immunity, and he has made fundamental contributions to the ligand characterization and immunobiology of TLR7, TLR8, TLR9, RIG-I, STING and cGAS. In their recent work, he and his group have discovered a pivotal mechanism by which RIG-I discriminates between foreign and self RNA, characterized the role of NLRP3 in NK-cell memory, discovered cyclic [G(2’,5’)pA(3’,5’)p] (cGAMP), the metazoan second messenger in the cGAS- STING pathway, and identified Y-form DNA as a minimal ligand for cGAS which is crucial for early HIV detection.