Institute of Experimental Immunology (IEI) & Medical Clinic III
Medical Faculty, University of Bonn
University Hospital of Bonn
Dr. Heine and her group are interested in the mechanisms governing antigen cross-presentation and cytotoxic T cell induction in the context of anti-tumor immune responses. Effective cancer vaccines should not only induce strong and durable T cell responses, but also optimally modulate the balance between suppressive and stimulatory factors in the tumor microenvironment. The aim of her research is the identification of novel immunotherapeutic strategies that accomplish both, with a special focus on different pathways of dendritic cell licensing and chemokine receptor modulation.