Steering committee-member, Member

Institute of Cardiovascular Immunology

Medical Faculty, University of Bonn
University Hospital of Bonn
Sigmund-Freud-Strasse 25
53105 Bonn


My research focuses on the mechanisms by which cytoplasmic RNA sensors RIG-I like receptors (RLRs) distinguish between viral RNAs and self-RNAs and trigger type I IFNs. Current work examines spontaneous autoimmune symptoms in RLR mutant mice derived via mutagenesis and how RLR-dysregulation causes autoimmune disease. I am also particularly interested in the analysis of immune responses and pathogenesis in virus infection in vivo and autoimmune diseases using mouse models.