Steering committee-member, Member
Life & Medical Sciences Institute (LIMES)
University of Bonn
Our group has the overarching aim to characterise the role of fetal-derived resident macrophages for organ development andfunction and how genetic and epigenetic perturbations can influence their homeostatic and immune functions. To achieve this, we are using genetic mouse models and human organoid cultures in combination with omics (transcriptome,proteome, lipidome, surfaceome). The ultimate goal is to describe novel mechanisms leading to metabolic and degenerativedisorders and define preventative measures targeting macrophages.