Department of Surgery
Medical Faculty, University of Bonn
University Hospital of Bonn
The aim of our research is to identify (neuro)-immunological mechanisms contributing to acute (postoperative) and chronic functional disturbances of the GI tract. In a series of publications our group demonstrated that interactions of resident immune cells and the enteric nervous system trigger postoperative bowel wall inflammation. This local neuroinflammation can be effectively modified by intrinsic and extrinsic neurotransmitters. With international collaborators we also investigate the neuroimmunology of chronic inflammatory bowel diseases. Currently, we are aiming to understand the initial trigger mechanisms of intestinal inflammation as well as to identify novel neuro-immune modulatory pathways. This will help us to gather a comprehensive understanding of acute and chronic intestinal inflammatory disorders.