The ImmunoSensation Cluster of Excellence places strong emphasis on the support of early careers and gender equality. Our four-layered Promotion Concept for graduate students, post docs, young investigators and group leaders will be supported by our special funding program and will provide exciting new career opportunities that will be further shaped through interactions with our local and international partners.

____________________________________________________________

 

PhD student positions (m/f/d) (65%)

The Cluster of Excellence ImmunoSensation2 is inviting applications for

PhD students 

at the Bonn Graduate School of Immunosciences and Infection.
Positions are initially limited to three years with the possibility of extension.

ImmunoSensation2 is a Cluster of Excellence funded by Germany’s Excellence Strategy at the University of Bonn. Participating scientists are dedicated to investigating innate immunity beyond the boundaries of classical immunology.
In a joint effort, immunologists, neurobiologists, systems biologists and mathematicians of the University of Bonn and the German Center for Neurodegenerative Diseases (DZNE) of the Helmholtz Association aim to connect the status of the immune system, the metabolism and the nervous system to disease states. ImmunoSensation2 is embedded into the outstanding research environment of the University of Bonn, the University Hospital and the DZNE. Furthermore, ImmunoSensation2 is internationally connected and maintains research partnerships with Australia (Melbourne University), Japan (Osaka University, Waseda University, Kyoto University) and the Netherlands (Radboud University, Nijmegen).
Students will have the opportunity to receive additional financial support to participate in an official student exchange program (3 to 6 months) with selected principal investigators at these partner universities.

PhD students will be admitted to the Bonn International Graduate School Immunosciences and Infection. In this structured PhD program, students gain experience with state-of-the-art technologies and become part of a vibrant scientific network and an internationally competitive scientific training program.

The ideal candidate will be highly motivated and team-oriented with a strong interest in immunology, a first-class academic degree in a life science-related discipline (Master’s degree or equivalent), a strong background in molecular biomedicine, molecular biology, biochemistry or cell biology and enthusiasm for working in the highly-competitive field of innate immunity research. Candidates should have strong communicative skills (fluent spoken and written English) since these are necessary for work in an international research landscape.

We offer:

  • The salary will be according to the German salary scale TV-L (EG 13)
  • There is also a possibility to use the day care center
  • Supplementary benefits in the public sector (pension plan according to VBL)

The University of Bonn is committed to diversity and equal opportunity. It is certified as a familyfriendly university. It aims to increase the proportion of women in areas where women are under-represented and to promote their careers in particular. It therefore urges women with relevant qualifications to apply. Applications will be handled in accordance with the Landesgleichstellungsgesetz (State Equality Act). Applications from suitable individuals with a certified serious disability and those of equal status are particularly welcome.

Applicants should send their application in a single pdf file (max. 5 MB) including motivation letter, CV, scanned academic degrees, list of publications and the contact details of two references.
More information on the scientific projects and project leaders can be found here: https://www.immunosensation.de/career/recruitment.html.
In your application, please indicate your preferred scientific project(s). More detailed
information will be provided during the recruitment process. Successful candidates
will begin on June1, 2020 or later.
Please send your application by email using the reference number 041_2020 to the
Cluster Coordination Office until April 15, 2020 to:

Dr. rer. nat. Catherine Drescher
Cluster of Excellence ImmunoSensation2
University Hospital Bonn
Venusberg-Campus 1
53127 Bonn
Phone: +49 (0)228/287-51288
Email: applications_immunosensation(at)ukbonn.de

 

Dagmar Wachten
Biophysical Imaging Institute of Innate Immunity University Hospital Bonn, University of Bonn

Analyzing the role of primary cilia in immune cell reprogramming The primary cilium constitutes a hair-like extension that protrudes from the surface of almost all vertebrate cells, where it acts as a cellular antenna. Dysfunction of primary cilia causes severe diseases, commonly referred to as ciliopathies. How primary cilia control cellular functions is not well understood. Generally, immune cells do not form the prototypical, elongated primary cilium. This is particularly true for hematopoietic cells. However, primary cilia dysfunction results in immune cell reprogramming. We will study how primary cilia control immune cell function in different tissue contexts under physiological and pathological conditions.

 

Veronika Lukacs-Kornek
Institute of Experimental Immunology University Bonn

Prof. Lukacs-Kornek and her team are focusing to determine the role and impact of stromal cells on immunregulation during priming in secondary lymphoid organs and within the tumor microenvironment. Stromal cell biology is an emerging field that investigates how these non-hematopoetic cells contribute to disease development. The PhD candidate will contribute in a research project that focuses on stroma-immune cell cross-talk in the tumor milieu. The applied techniques involve flow cytometry, working with in vivo animal models involving cell culture and confocal/intravital microscopy analyses. The candidate will learn various immunological assays to address the function of stromal cells and will use genomic analyses to address the various subpopulations within and outside of the tumor environment. 

Fernando Magdaleno Verduzco
Institute of Experimental Immunology

The project will address the role of immune cells, especially macrophages (MF) and dendritic cells during cGN, and translate the findings to patients with cGN. The long-term aim is to obtain a better understanding of renal DC/MF in cGN and identify targets for therapeutic strategies. Close interactions exist in addition with GRK2168 and the SFBTR57. We offer a well-equipped laboratory and the doctoral student will also participate in a structured program that promotes scientific education and long-term development of scientists to pursue their career in the field of translational science in chronic kidney disease. 

Elvira Mass
LIMES Developmental Biology of the innate immune system

The Mass lab is looking for a PhD candidate with a strong neuroscience, neurodevelopment and/or immunology background to study the role of maternal obesity in the development of neurological disorders. The position is for 3 years with a possible extension. The employment is planned to start on 1 April or upon agreement. The goal of the project is to characterize the developmental programming events of microglia driven by maternal metaflammation and whether this can lead to neurodevelopmental disorders. As model systems, we use mice and brain organoids. Further methods include histology, electrophysiology, behavioural tests, single-cell RNA-sequencing, and flow cytometry. The candidate is required to hold an M.Sc. degree in neuroscience/developmental biology/immunology or similar topics. We are looking for candidates with hands-on experience or an interest in expanding their knowledge in molecular biology, high-dimensional flow cytometry, confocal microscopy, and bioinformatic analyses (particularly scRNA-seq). Experience with mice, iPSC-derived organoids, and background in R/Python is a plus.

Natalio Garbi
The Department of Cellular Immunology at the Institute of Experimental Immunology of the Medical Faculty, University of Bonn

The Garbi Lab is seeking for a highly motivated PhD student to investigate the maternal-fetal interface in the regulation of immune responses in the adult offspring. Particularly we are interested in understanding how maternal immune responses during pregnancy shape future immune responses to allergens and microbial stimuli in the offspring. The student will gain expertise in state-of-the-art technologies such as multicolour flow cytometry, spectral confocal microscopy, mRNAseq, metabolomics, proteomics, and various animal disease models. The student will join a highly dynamic, multidisciplinary and international environment with a strong focus on immunology, and will become a member of the International Immunology Training Program that gives access to state-of-the-art training and workshops covering different scientific aspects. The Institute of Experimental Immunology has a long-standing, internationally-recognised research expertise on basic and applied aspects of cellular immunology. It currently has over 50 staff members including three professors, four group leaders and over 30 scientists and PhD students. The position is available immediately for a period of three years with the possibility of extension. For further information on Prof. Garbi's group and how to apply please visit www.iei-bonn.de or email ngarbi@uni-bonn.de.

Christoph Wilhelm
Institute of Clinical Chemistry and Clinical Pharmacology

Our lab is focused on a unique group of immune cells, called innate lymphoid cells (ILC). We are trying to understand how these cells protect the body's barrier sites, such as the lungs, skin, and gut but also how they cause immune pathology upon chronic activation. In particular, we aim to determine how exogenous and endogenous metabolites control the function of ILC in health and disease. Our ultimate goal is to understand the link between Westernization and the growing health problem of chronic inflammatory conditions such as inflammatory bowl disease (IBD) and asthma. 

Annkristin Heine
Institute of Experimental Immunology & Medical Clinic III

Our group identifies biomarkers for and mechanisms of anti-tumor therapy resistance, develop novel strategies that aim to improve anti-tumor immune responses and investigate novel concepts for graft-versus-host-disease (GvHD) after allogeneic bone marrow transplantation. Furthermore, we analyze the impact of the tumor microenvironment and the influence of chemokines in different hematologic malignancies and solid tumors. The candidate will establish different pre-clinical tumor models, analyze tumor-infiltrating immune cells and identify mechanisms that can improve anti-tumor immune responses or GvHD.

Katrin Paeschke
Medical Clinic III
The lab of Prof. Dr. Katrin Paeschke (www.paeschkelab.de) is looking for a highly motivated and determined candidate for a PhD position. The PhD student will elucidate the function of a specific alternative DNA structures for the activation of innate Immunity. Especially the connection of genome instability events and immune response will be a focus of this research project. Specifically, in the course of this project the student will genome wide, biochemical and molecular biological techniques in human tissue culture cells to shed light on fundamental questions in the field of genome instability, DNA repair pathways and immune response. Especially, the contribution and function of the alternative DNA structure (G-quadruplex), makes this topic also interesting for questions in oncology and viral infection.

Selina K. Jorch
Institute of Experimental Immunology

The Jorch lab (http://www.iei-bonn.de/research-interests/dr-selina-jorch.html) is seeking for a highly motivated and talented PhD student with a strong interest in immunology, autoinflammatory syndromes and infections. The focus of this PhD project is in the field of neutrophil, monocyte and macrophage cell recruitment, migration and interaction in animal models of autoinflammatory diseases like FMF or PAPA-Syndrome and infections. To investigate these processes the candidate will use beside classical immunological methods the cutting-edge technique of intravital two-photon microscopy that provides a unique window into these dynamic processes in different organs. The position is for 3 years with a possibility for extension.

Data Scientists in Bioinformatics (m/f/d) (100%)

The Cluster of Excellence ImmunoSensation2 and the Core Unit for Bioinformatic Data Analysis are inviting applications for


Data Scientists in Bioinformatics (m/f/d) (100%)

The position is initially limited to three years with the possibility of extension. ImmunoSensation2 is a Cluster of Excellence funded by Germany’s Excellence Strategy at the University of Bonn. Its scientists are dedicated to investigating innate immunity beyond the boundaries of classical immunology. In a joint effort, immunologists, neurobiologists, systems biologists and mathematicians from the University of Bonn and the German Center for Neurodegenerative Diseases (DZNE) of the Helmholtz Association aim to investigate how the status of the immune system, the metabolism and the nervous system connect in health and disease. ImmunoSensation2 is embedded in the outstanding research environment of the University of Bonn, the University Hospital and the DZNE.
Furthermore, ImmunoSensation2 is internationally connected and maintains research partnerships with Australia (Melbourne University), Japan (Osaka University, Waseda University, Kyoto University) and the Netherlands (Radboud University, Nijmegen). The announced position will be integrated into the Core Unit for Bioinformatics Data Analysis (CUBA) of the Medical Faculty at the University of Bonn, which provides quantitative and computational analyses, training and consultation for all members of the faculty. CUBA benefits from a shared computing infrastructure and exchange of expertise due to its embedding and liaison with the Institut für Medizinische Biometrie, Informatik und Epidemiologie (IMBIE) and the Institute for Genomic Statistics and Bioinformatics (IGSB). It operates in close collaboration with other core units like the NGS, flow cytometry and mass spectrometry core. The unit aims to establish a platform for computational biology, to facilitate quantitative approaches and to share and offer validated methods, expertise and resources. These methods will continuously evolve according to the needs of collaborators and progress in science to provide state-of-the-art bioinformatics and data analyses.

Your tasks:

  • Analysis and processing of high-volume data sets such as next generationsequencing
  • Design, implementation and application of tailored analysis workflows
  • Statistical analysis and visualization
  • Interaction and collaboration with researchers
  • Consultation regarding the planning and design of experiments
  • Presentation and reporting of results
  • Recommendation of publicly available resources and tools
  • Working in a team with bioinformatic and computational colleagues
  • Selection and adaption of (bioinformatical) methods and tools
  • Training courses and education

Your profile:

  • Master or PhD in bioinformatics, computational biology, computer science, statistics, mathematics or any other related field
  • Strong expertise in the analysis of next generation sequencing data (NGS), such as single cell genomics, RNA-Seq, ChIP-Seq and ATAC-Seq
  • Profound knowledge of statistics, data analysis and visualisation techniques
  • Proficiency in programming, e.g. with R/Bioconductor or Python
  • Experience with Linux and high-performance computing (HPC)
  • Background in molecular biology concepts and an interest in immunology
  • Knowledge of high-throughput image analysis (FACS ImageStream) is considered a plus
  • Good communication and presentation skills and fluency in written and spoken English
  • Team player capable of adapting to a rapidly evolving and interdisciplinary research environment

We offer:

  • There is also a possibility to use the day care center
  • Supplementary benefits in the public sector (pension plan according to VBL)
  • Salary according to the German salary scale TV-L (EG 13)

The University of Bonn is committed to diversity and equal opportunity. It is certified as a family-friendly university. It aims to increase the proportion of women in areas where women are under-represented and to promote their careers in particular. It therefore urges women with relevant qualifications to apply. Applications will be handled in accordance with the Landesgleichstellungsgesetz (State Equality Act). Applications from suitable individuals with a certified serious disability and those of equal status are particularly welcome.


Applicants should send their application in a single pdf file (max. 5 MB), including a motivation letter, CV, scanned academic degrees, a list of publications and the contact details of two references. More information on the scientific projects and project leaders can be found at www.immunosensation.de and information on CUBA can be found at https://cores.ukb.uni--bonn.de/bioinformatics/


Further details will also be provided during the recruitment process. Applications will be accepted on rolling basis and successful candidates can begin on May 1, 2020 or later.


Please send your application by email using the reference number 047_2020 to
Dr. rer. nat. Catherine Drescher
Cluster of Excellence ImmunoSensation2
Email: applications_immunosensation(at)ukbonn.de
www.immunosensation.de
University Hospital Bonn
Venusberg--Campus 1
53127 Bonn