The ImmunoSensation Cluster of Excellence places strong emphasis on the support of early careers and gender equality. Our four-layered Promotion Concept for graduate students, post docs, young investigators and group leaders will be supported by our special funding program and will provide exciting new career opportunities that will be further shaped through interactions with our local and international partners.

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Postdoctoral fellow (m/f/d) – metabolic and nutritional regulation of immune cells

The Institute of Clinical Chemistry and Clinical Pharmacology at the Faculty of Medicine of the Rheinische Friedrich Wilhelms-University Bonn invites applications for a


Postdoctoral fellow (m/f/d) – metabolic and nutritional regulation of immune cells


We are seeking a highly motivated postdoctoral fellow to conduct research on the fundamental aspects of metabolic regulation of the immune system. The Project aims to understand how metabolites derived from the host, the diet or the microbiome shape the biology and metabolism of tissue resident immune cells in
health and disease. In particular the work aims to identify how diets (e.g. ketogenic diets), dietary components and metabolites modulate the immune response in chronic inflammation and infections (Karagiannis et al. Immunity 2020, Karagiannis et al. Nature 2022)). The candidate will have the opportunity
to obtain additional external funding and develop an independent research program during the postdoctoral training.


We are looking for an enthusiastic scientist with a desire to work on a challenging and rewarding project as part of a friendly and supportive team. Applicants with Ph.D. degree and graduate students expecting to receive the degree within six months will be considered. The ideal candidate will have a background in immunology, tissue biology or cellular metabolism. Experience in working with animal models, cell isolations from tissues (lung, intestine), multi-parameter flow cytometry, molecular biology and fluorescence imaging will be preferred.


The University Hospital Bonn is an equal opportunity employer offering attractive conditions and benefits. We offer an interdisciplinary research institution that fosters innovation and collaboration and are committed to training and career development of the next generation of scientists. The position is available for an initial period of three years with the possibility of extension.


We offer

• The salary will be according to the German salary scale TV-L (EG 13, 100%)
• A “Jobticket” (subsidized public transport)
• Possibility to use the day care center
• Supplementary benefits in the public sector (pension plan according to VBL)


The University of Bonn is committed to diversity and equal opportunity. It is certified as a family-friendly university. It aims to increase the proportion of women in areas where women are under-represented and to promote their careers in particular. It therefore urges women with relevant qualifications to apply.

Applications will be handled in accordance with the Landesgleichstellungsgesetz (State Equality Act). Applications from suitable individuals with a certified serious disability and those of equal status are particularly welcome.
Applications should include names and addresses of three referees and be send preferably by e-mail under indication of reference number until October 31st 2022 to Prof. Christoph Wilhelm (christoph.wilhelm@unibonn.de).


Prof. Christoph Wilhelm
Institute of Clinical Chemistry and Clinical Pharmacology
Biomedical Center, 1G024
University Hospital Bonn
University of Bonn
Venusberg-Campus 1
Bonn 53127
Germany
Tel.: +49 (0) 228 287 51721
e-mail: christoph.wilhelm(at)uni-bonn.de

PhD Position in Neurovascular Cell Biology (m/f/d)

The central nervous system (CNS) (brain and spinal cord) is composed of
different neural cell types organized in a very stereotyped pattern and
localized in defined compartments. Apart of the neuronal cell types, the
CNS is also composed of blood vessels, responsible for providing oxygen
and nutrients to the neuronal tissue. Similar to neurons, during
development, blood vessels also follow defined pathways to enter and
invade the CNS in order to assure proper oxygen and nutrient delivery to
all parts of the tissue.


In this project we aim to identify and characterize the molecular
mechanisms of the bidirectional communication between neural cells and
cells forming the vasculature in development, homeostasis and disease. In
disease, the interaction of the vasculature with the immune system will also
be explored. We intend to understand how different neuronal populations
control CNS vascularization and how the vasculature also actively
contributes to the development and maintrenance of CNS homeostasis.


References


Luck R, Karakatsani A, Shah B, Schermann G, Adler H, Kupke J, Tisch N, Jeong HW, Back MK, Hetsch F, D`Errico A, De Palma M, Wiedtke E, Grimm D, Acker-Palmer A, von Engelhardt J, Adams RH, Augustin HG, Ruiz de Almodovar C. The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner. Cell Rep. 2021, 36(7), 109522.

Paredes I, Vieira JR, Shah B, Ramunno CF, Dyckow J, Adler H, Richter M, Schermann G, Giannakouri E, Schirmer L, Augustin HG, Ruiz de Almodovar C. Oligodendrocyte precursor cell specification is regulated by bi-directional neural progenitor-endothelial cell crosstalk. Nat Neurosci. 2021, 24, 478–488.

Vieira JR, Shah B, Ruiz de Almodovar C. Cellular and molecular mechanisms of spinal cord Institute for Neurovascular Cell Biologyvascularization. Front Physiol 2020. Dec 21

Luck R*, Urban S*, Karakatsani A, Harde E, Sambandan S, Nicholson L, Haverkamp S, Mann R, Martin-Villalba A, Schuman EM, Acker-Palmer A, Ruiz de Almodóvar C. VEGF/VEGFR2 signaling regulates hippocampal axon branching during development. Elife. 2019 Dec 23;8.

Karakatsani A, Shah B, Ruiz de Almodovar C. Blood vessels as regulators of neural stem cell properties. Front Mol Neurosci 2019 Apr 12;12:85

Paredes I, Himmels P, Ruiz de Almodovar C. Neuro-vascular communication in the CNS during development. Dev Cell. 2018. Apr 9;45(1):10-32

Wang X, Freire Valls A, Shermann G, Shen X, Moya IM, Castro L, Urban S, Solecki GM, Winkler F, Riedemann Lm Jain RK, Mazzone M, Schmidt T, Fischer T, Halder G, Ruiz de Almodovar C. YAP/TAZ orchestrate VEGF signaling during developmental angiogenesis. Dev Cell. 2017 Sep 11;42(5):462-478.e7.

Himmels P, Paredes I, Karakatsani A, Luck R, Marti H, Rempel E. Stoeckli E & Ruiz de Almodovar, C. Motoneurons guide blood vessels in the developing spinal cord via a sFlt1 dependent mechanism. Nat Commun. 2017 Mar 6;8:14583.


Methods that will be used


Single cell sequencing and spatial transcriptomics
Mouse genetics
Micro-dissections
Ex vivo 3D cell culture
In vitro cell culture
Cell Biology
Biochemistry and Molecular Biology techniques
Histology
Immunohistochemisty
Light and fluorescent microscopy
Confocal microscopy


Profile of candidate’s qualification

The candidate should be an enthusiastic and motivated student willing tojoin an international research group in a highly dynamic working environment (with English as main language). The ideal candidate should have a biomedicine, neuroscience, biology or a biochemical and molecular biology background.


Application

For further details on the application procedure, please
send an email with your CV, letter of motivation and contacts for
references to: carmen.ruizdealmodovar(at)ukbonn.de

 

Prof. Dr. Carmen Ruiz de Almodóvar
Director
Schlegel Chair
Tel. +49 228 688-530328
carmen.ruizdealmodovar@ukbonn.de
Life & Brain Center
University hospital Bonn
Venusberg-Campus 1, Geb. 76
53127 Bonn