The University Hospital Bonn is a maximum care facility with a regular capacity of 1.300 beds. Our current staff of more than 8.000 performs assigned duties in research, teaching and medical treatment, including the use of advanced medical technologies, and public health care services at the highest possible level. Interested applicants will be offered a wide range of employment opportunities in a variety of fields.
The Cluster of Excellence ImmunoSensation2 is inviting applications for
PhD student positions (m/f/d) (65%)
at the Bonn Graduate School of Immunosciences and Infection
Positions are initially limited to three years with the possibility of extension. ImmunoSensation2 is a Cluster of Excellence funded by Germany’s Excellence Strategy at the University of Bonn. Participating scientists are dedicated to investigating innate immunity beyond the boundaries of classical immunology. In a joint effort, immunologists, neuro-biologists, systems biologists and mathematicians of the University of Bonn and the German Center for Neurodegenerative Diseases (DZNE) of the Helmholtz Association aim to connect the status of the immune system, the metabolism and the nervous system to disease states.
ImmunoSensation2 is embedded into the outstanding research environment of the University of Bonn, the University Hospital and the DZNE. Furthermore, ImmunoSensation2 is internationally connected and maintains research partnerships with Australia (Melbourne University), Japan (Osaka University, Waseda University, Kyoto University) and the Netherlands (Radboud University, Nijmegen). Students will have the opportunity to receive additional financial support to participate in an official student exchange program (3 to 6 months) with selected principal investigators at these partner universities.
PhD students will be admitted to the Bonn International Graduate School Immunosciences and Infection. In this structured PhD program, students gain experience with state-of-the-art technologies and become part of a vibrant scientific network and an internationally competitive scientific training program.
The ideal candidate will be highly motivated and team-oriented with a strong interest in immunology, a first-class academic degree in a life science-related discipline (Master’s degree or equivalent), a strong background in molecular biomedicine, molecular biology, biochemistry or cell biology and enthusiasm for working in the highly-competitive field of innate immunity research. Candidates should have strong communicative skills (fluent spoken and written English) since these are necessary for work in an international research landscape.
- The salary will be according to the German salary scale TV-L (EG 13)
- A “Jobticket” (subsidized public transport) is available
- There is also a possibility to use the day care center
- Supplementary benefits in the public sector (pension plan according to VBL)
The University of Bonn is committed to diversity and equal opportunity. It is certified as a family-friendly university. It aims to increase the proportion of women in areas where women are under-represented and to promote their careers in particular. If therefore urges women with relevant qualifications to apply. Applications will be handled in accordance with the Landesgleichstellungsgesetz (State Equality Act). Applications from suitable individuals with a certified serious disability and those of equal status are particularly welcome.
Applicants should send their application in a single pdf file (max. 5 MB) including motivation letter, CV, scanned academic degrees, list of publications and the contact details of two references. In your application, please indicate your preferred scientific project. More information on the scientific projects and project leaders can be found here: www.immunosensation.de, and more detailed information will be provided during the recruitment process. Successful candidates will begin on May 1, 2021 or later.
Please send your application by email using the reference number 768_2020 to the Cluster Coordination Office until January, 15 2021 to
Dr. rer. nat. Catherine Drescher
Cluster of Excellence ImmunoSensation2
University Hospital Bonn
Phone: +49 (0)228/287-51288
Institute of Clinical Chemistry and Clinical Pharmacology
Dietary immunology is an emerging field that investigates how dietary compounds and metabolites regulate the immune system. The project will investigate how diets (e.g. ketogenic diets) and dietary components drive or prevent chronic inflammation and includes the analysis of metabolic pathways controlling innate lymphoid cells (ILC) (Karagiannis et al. Immunity 2020). To investigate these processes the candidate will use mouse models, classical immunological methods but also cutting-edge technologies, such as imaging flow cytometry, metabolomics and extracellular flux analysis. The overall aim is to identify novel dietary intervention strategies to treat chronic inflammatory conditions such as asthma and colitis. Candidates with experience in cellular immunology, molecular cell biology or biochemistry are specifically encouraged to apply.
Medical Clinic III for Oncology, Hematology, Immuno-Oncology and Rheumatology
Research in the group of Prof. Dr. Dirk Baumjohann at the Medical Clinic III for Oncology, Hematology, Immuno-Oncology and Rheumatology focuses on T helper cells, which coordinate cellular and antibody-mediated immune responses to a variety of pathogens. While several distinct T helper cell subsets have been described in the past, new research indicates that T helper cell differentiation is characterized by a considerable degree of flexibility and plasticity. We have a long-standing interest in T follicular helper (Tfh) cells, which represent the prototypic T helper cell subset that provides help to B cells for efficient antibody responses. For this PhD student project, we seek a highly motivated candidate that will combine cellular and molecular immunology techniques with in vivo disease models, patient-derived samples, and single-cell genomics to dissect the mechanisms of Tfh cells at the crossroads of immunity and autoimmunity. Previous hands-on experience in immunological techniques such as multidimensional flow cytometry and in vivo models is desired. Experience in human immunology and in conducting and analyzing scRNA-seq experiments is a plus. Good communication skills and fluency in English are essential.
For more information please visit:
Cellular Virology, Insitute of Cardiovascular Immunology
The research group "Cellular Virology" investigates the interaction between viral infections and innate immunity. These innate defense processes are evolutionary conserved pathways restricting viral replication and spread. However, viruses developed immune evasive mechanisms circumventing these functions or even using them for their own benefit. The PhD project will investigate pro- and antiviral mechanisms of innate immunity using the example of hepatitis B virus infection. A special focus of this advertised thesis project will be on so-called subviral particles which are released in large numbers by infected cells and contain immunomodulatory viral components. The influence of these subviral particles on HBV immune recognition and the resulting consequences for the viral life cycle will be investigated. The small group size enables a good methodical education and excellent supervision at the fascinating interface between viruses, the innate immune system and the new innovative field of extracellular signaling pathways.
Elvira Mass and Waldemar Kolanus
Life & Medical Sciences Institute (LIMES)
The Mass and Kolanus labs are looking for 2 PhD candidates, preferably with a strong immunology background, to study the role of high-salt diet in the development and function of myeloid cells. The position is for 3 years with a possible extension. The goal of the project is to characterize the cellular programming events of dermal macrophages driven by metaflammation and whether this can lead to changes in their immunological function. As model systems, we use mice and in vitro migration assays. Further methods include histology, cell culture, single-cell RNA-sequencing, and flow cytometry. The candidate is required to hold an M.Sc. degree in biology/immunology or similar topics. We are looking for candidates with hands-on experience or an interest in expanding their knowledge in molecular biology, high-dimensional flow cytometry, confocal microscopy, and bioinformatic analyses (particularly scRNA-seq). Experience with mice and background in R/Python is a plus.
Systems Biology of Inflammation, Bridging Program Biomathematics, ImmunoSensation cluster of excellence.
The mammalian immune response depends on the interaction and collaboration of many highly individual cells. Our group uses mathematical modeling and data analysis tools to quantify and rationalize immune cell dynamics in the context of clinical manifestations such as chronic inflammation and cancer. The group is currently moving from Berlin to Bonn, and will be integrated into both the ImmunoSensation cluster and the Hausdorff Center for Mathematics, an exceptional environment for our interdisciplinary research program. We are currently recruiting 2 PhD students for data-driven modeling of cell-cell communication networks in two areas: innate lymphoid cells and T cells driving autoimmune organ damage, and tumor immune escape in response to T cell therapy. Both projects will be carried out in tight collaboration with wet-lab immunologists and will include first-hand data analysis as well as mathematical model development. The projects may comprise stochastic and spatial modelling techniques as well as analysis of single-cell sequencing and high-content imaging data, thus offering ample opportunity for expert training in modern systems immunology. We are looking for highly motivated, independent and committed scientists eager to make significant contributions to both fundamental and clinical research. Ideally, candidates have a Master degree in (bio-)physics, systems biology, mathematics, computer science, or a related discipline. Good computer programming skills are required, training in immunology or cell biology is an advantage. The position requires good communication and interpersonal skills, and fluent English. For more information, visit https://www.thurleylab.org.
Institute of Pharmacology and Toxicology
Obesity has become a worldwide threat to the public health and efficient treatments are urgently needed. Obesity is characterized by an unhealthy increase in adipose tissue, due to hypertrophy and hyperplasia of adipocytes. In addition, during development of obesity inflammatory processes are involved as observed by massive influx of immune cells, e.g. myeloid cells, into adipose tissue. This inflammatory state of adipose tissue affects also other organs and results in obesity associated co-morbidities like insulin resistance, cardiovascular disease, and diabetes (Sanyal et al., 2017). Two types of adipose tissue do exist, white adipose tissue (WAT) and brown adipose tissue (BAT) (Pfeifer and Hoffmann, 2015). Whereas WAT is mostly considered to be the main storage for body fat, BAT is characterized as specialized fat tissue that is able to dissipate energy as heat. This metabolically active adipose tissue has been discovered in adult humans and it is considered as an attractive target for developing anti-obesity therapies (Gnad et al., 2014). Brown-like fat cells were also identified within WAT and contribute to energy expenditure (Hoffmann et al., 2015; Mitschke et al., 2013). In obesity, BAT function is impaired and its phenotype switches to WAT. Within this project we would like to investigate the role of different immune cell subsets especially in BAT and WAT function and plasticity.
Gnad, T., Scheibler, S., von Kugelgen, I., Scheele, C., Kilic, A., Glode, A., Hoffmann, L.S., Reverte-Salisa, L., Horn, P., Mutlu, S., et al. (2014). Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors. Nature 516, 395-399.
Hoffmann, L.S., Etzrodt, J., Willkomm, L., Sanyal, A., Scheja, L., Fischer, A.W., Stasch, J.P., Bloch, W., Friebe, A., Heeren, J., et al. (2015). Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue. Nature communications 6, 7235.
Mitschke, M.M., Hoffmann, L.S., Gnad, T., Scholz, D., Kruithoff, K., Mayer, P., Haas, B., Sassmann, A., Pfeifer, A., and Kilic, A. (2013). Increased cGMP promotes healthy expansion and browning of white adipose tissue. FASEB J 27, 1621-1630.
Pfeifer, A., and Hoffmann, L.S. (2015). Brown, beige, and white: the new color code of fat and its pharmacological implications. Annu Rev Pharmacol Toxicol 55, 207-227.
Sanyal, A., Naumann, J., Hoffmann, L.S., Chabowska-Kita, A., Ehrlund, A., Schlitzer, A., Arner, P., Bluher, M., and Pfeifer, A. (2017). Interplay between Obesity-Induced Inflammation and cGMP Signaling in White Adipose Tissue. Cell Rep 18, 225-236.