The central nervous system (CNS) (brain and spinal cord) is composed of
different neural cell types organized in a very stereotyped pattern and
localized in defined compartments. Apart of the neuronal cell types, the
CNS is also composed of blood vessels, responsible for providing oxygen
and nutrients to the neuronal tissue. Similar to neurons, during
development, blood vessels also follow defined pathways to enter and
invade the CNS in order to assure proper oxygen and nutrient delivery to
all parts of the tissue.
In this project we aim to identify and characterize the molecular
mechanisms of the bidirectional communication between neural cells and
cells forming the vasculature in development, homeostasis and disease. In
disease, the interaction of the vasculature with the immune system will also
be explored. We intend to understand how different neuronal populations
control CNS vascularization and how the vasculature also actively
contributes to the development and maintrenance of CNS homeostasis.
Luck R, Karakatsani A, Shah B, Schermann G, Adler H, Kupke J, Tisch N, Jeong HW, Back MK, Hetsch F, D`Errico A, De Palma M, Wiedtke E, Grimm D, Acker-Palmer A, von Engelhardt J, Adams RH, Augustin HG, Ruiz de Almodovar C. The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner. Cell Rep. 2021, 36(7), 109522.
Paredes I, Vieira JR, Shah B, Ramunno CF, Dyckow J, Adler H, Richter M, Schermann G, Giannakouri E, Schirmer L, Augustin HG, Ruiz de Almodovar C. Oligodendrocyte precursor cell specification is regulated by bi-directional neural progenitor-endothelial cell crosstalk. Nat Neurosci. 2021, 24, 478–488.
Vieira JR, Shah B, Ruiz de Almodovar C. Cellular and molecular mechanisms of spinal cord Institute for Neurovascular Cell Biologyvascularization. Front Physiol 2020. Dec 21
Luck R*, Urban S*, Karakatsani A, Harde E, Sambandan S, Nicholson L, Haverkamp S, Mann R, Martin-Villalba A, Schuman EM, Acker-Palmer A, Ruiz de Almodóvar C. VEGF/VEGFR2 signaling regulates hippocampal axon branching during development. Elife. 2019 Dec 23;8.
Karakatsani A, Shah B, Ruiz de Almodovar C. Blood vessels as regulators of neural stem cell properties. Front Mol Neurosci 2019 Apr 12;12:85
Paredes I, Himmels P, Ruiz de Almodovar C. Neuro-vascular communication in the CNS during development. Dev Cell. 2018. Apr 9;45(1):10-32
Wang X, Freire Valls A, Shermann G, Shen X, Moya IM, Castro L, Urban S, Solecki GM, Winkler F, Riedemann Lm Jain RK, Mazzone M, Schmidt T, Fischer T, Halder G, Ruiz de Almodovar C. YAP/TAZ orchestrate VEGF signaling during developmental angiogenesis. Dev Cell. 2017 Sep 11;42(5):462-478.e7.
Himmels P, Paredes I, Karakatsani A, Luck R, Marti H, Rempel E. Stoeckli E & Ruiz de Almodovar, C. Motoneurons guide blood vessels in the developing spinal cord via a sFlt1 dependent mechanism. Nat Commun. 2017 Mar 6;8:14583.
Methods that will be used
Single cell sequencing and spatial transcriptomics
Ex vivo 3D cell culture
In vitro cell culture
Biochemistry and Molecular Biology techniques
Light and fluorescent microscopy
Profile of candidate’s qualification
The candidate should be an enthusiastic and motivated student willing tojoin an international research group in a highly dynamic working environment (with English as main language). The ideal candidate should have a biomedicine, neuroscience, biology or a biochemical and molecular biology background.
For further details on the application procedure, please
send an email with your CV, letter of motivation and contacts for
references to: carmen.ruizdealmodovar(at)ukbonn.de
Prof. Dr. Carmen Ruiz de Almodóvar
Tel. +49 228 688-530328
Life & Brain Center
University hospital Bonn
Venusberg-Campus 1, Geb. 76