Neurodegeneration meets neuroinflammation: the mutual interactions between immune cells and neurons.
In this year's Venusberg Meeting on Neuroinflammation a special emphasis will be put on the interaction between neurodegenerative and neuroinflammatory mechanisms.
Speakers from all areas of neuroinflammation will present the most recent findings and developments in order to stimulate vivid and challenging discussions. More information on the program, venue and registration can be found at the website of the DZNE www.dzne.de/Venusbergmeeting2019
Date and Time:
9th May 2019 (9.00 a.m) - 11 May 2019 (5.00 p.m)
A team formed by researchers from the Institute of Innate Immunity, the Institute of Experimental Immunology of the University of Bonn, and the University of Massachusetts Medical School have unraveled a long standing enigma in crystal-induced chronic inflammation.
It has been known, since 1850, that eosinophil infiltration into tissues results in the accumulation of large extracellular crystals known as Charcot-Leyden crystals (CLCs). CLCs have now been extensively described in the lungs of asthmatics patients as well as in patients with allergic reactions, helminthic infections and in the nose of chronic rhinosinusitis patients. Research on this topic has been considerably slow, for example, it took another 120 years for the biochemical characterization of these crystals, formed by a protein Galectin-10, which is enriched in eosinophil granules. Since then, another gap in knowledge was that their function or activity remained unknown. Whether these crystals are merely a marker of eosinophil demise, or play any role in the disease progression.
The new study published this week in the Journal of Immunology shows that Charcot-Leyden crystals induce a strong inflammatory response driven by interleukin-1 after the activation of the pattern recognition receptor NLRP3 and formation of inflammasomes. The study suggests that a product of eosinophil degranulation can sustain immune activity, which could have important implications for the development of chronic diseases such as allergic asthma, a chronic airway inflammatory disease that affects 8-12% of people in Europe.
Dr. Eva Bartok from the Institute of Clinical Chemistry and Pharmacology was awarded the Universitätsgesellschaft Bonn (UGB) Bonner Preis für Medizin (Bonner Prize for Medicine) for her outstanding doctoral thesis in the field of medicine. The prize which is sponsored by Prof. Dr. Rolf Dederich and the UGB has been awarded annualy since 2012 and carries a cash reward of 5000 euros.
The scientists examined the coding genes of three families that are not related to each other and are of different ancestry. A total of eight relatives showed the typical symptoms of hair loss. All those affected had mutations in the LSS gene. “This gene encodes lanosterol synthase - LSS for short,” said Prof. Dr. Regina C. Betz from the Institute of Human Genetics at the University Hospital of Bonn. “The enzyme plays a key role in cholesterol metabolism.” However, the cholesterol blood values of those affected are not changed. Betz: “There is an alternative metabolic pathway for cholesterol, which plays an important role in the hair follicle and is not related to blood cholesterol levels."
The much awaited Excellence Strategy funding decision by the DFG was received with cheers and applause! As the Rector of the University of Bonn, Prof. Michael Hoch, read the list of the 6 funded Excellence Clusters from the DFG website, the room was filled with joy and cheers!
ImmunoSensation² and 5 other Clusters were successful in their application. This was a significant moment, as the University of Bonn was the only University in Germany to receive funding for six Clusters of Excellence.
We congratulate all ImmunoSensation scientists for their hard work and we look forward to achieving greater heights!!
We also congratulate: The Hausdorff Center for Mathematics, Beyond Slavery and Freedom, PhenoRob, ML4Q and ECONtribute!
Change in technology has brought with it convenience in the medical sector, with just a click of a button, patients and doctors have access to a lot of information.
As part of the 200 years jubilee celebrations of the University of Bonn, Immunosensation together with the Medical Faculty organized an open lecture for the public on this topic. Prof. Nicolas Wernert Dean of the Faculty of Medicine, gave a public lecture on the actual trends in the digitalization of medicine. His talk broadly covered actual tread starting from intergration of multi-omics, 3D printing of organs and tumors, standard Health-Apps on mobile phones to minimal invasive surgery using robotics. The lecture was directly followed by a podium discussion with experts in the fields related to it.
The topic of digitalization is a sensitive one and with it alot of ethical and legal implications, therefore, to efficiently discuss this topic, the members of the panel consisted of experts from the legal sector, ethics, medical and private sector. Members of the podium were : Prof. Dr. Nicolas Wernert - Dean Faculty of Medicine, University of Bonn, Prof. Dr. Dr. Mariacarla Gadebusch Bondio – Director, Institute of Medical History, University Hospital Bonn, Katrin Reuter – Founder trackle GmbH, Prof. Dr. Markus Nöthen – Director, Institute of Human Genetics, University of Bonn and Prof. Dr. iur. Dirk Böhmann - Legal advisor for medical and labor laws, German Association of University Professors and Lecturers. The event was moderated by Jan Niklas Hansen, Doctoral candidate at the Institute of Innate Immunity, University of Bonn.
The chemotactic protein CCL17 attracts immune cells to where they are currently needed. Doctors have long known: A high level of this substance in the body indicates an allergic reaction. A team of scientists led by the University of Bonn has now discovered a completely new function: CCL17 also influences signal transmission in the brain. There may even be a molecular link to autism. The results have now been published in the journal “GLIA”.
The article which they published in Glia is available online DOI: 10.1002/glia.23507
Integrity in research is more of a necessity than a luxury and reseachers should alway perform their work with this in mind. PRINTEGER was a EU funded Project which came to an end on the 31st Aug 2018 and their mission was to enhance research integrity. During their project, Upright which is an interactive educational tool on research intergrity was developed.
Upright aims at promoting research intergrity with more the question " What kind of researcher should I be?" rather than "what should I do?". It also provides information and oppourtunities for debate and reflection. Intergrity in research is not a one off committment, but rather a lifelong one.
The two teams went head to head, with each having 3 slammers from all over Germany that who presented on their respective disciplines. In the end, the public was charged with the task of determining the winner through casting of beads. And through a clear vote, measured on measuring cylinders ImmunoSensation and its biomedicine team won. Roman Stilling who presented on microbiome was selected as the slammer of the night.
This is the second time that a cluster scientist has won this prestigious prize! in 2014, Tobias Bald received the same prize! Congratulations Nicole Glodde and the entire Prof. Hölzel lab!
The efforts of Cluster scientists is very well reflected with the increase in funding, as shown by the DFG funding atlas. The DFG funding atlas for the period 2014 -2016 places us in 1st position in NRW and 3rd in the whole of Germany. During the 2014-2016 funding period, we received a total of 19.7 million euros, which was 3.4 million more than in 2011-2013 period.
The Medical Faculty was standing strong among the Top 10 in Germany (9 out of 85) having raised a total of 60.4 million euros. Neurosciences also moved up to position 7, having received a total of 16.3 million.
Congratulations for all the hard work!
Find the full press release here.
The forsch magazine is a publication of the University of Bonn featuring interesting and top ongoing research in various disciplines at the University.
The 2018 summer edition featured articles from 3 cluster scientist:
Dr. Florian Schmidt on his Nanobodies research and their generation using Alpacas (pg. 22), Prof. Dr. Heinz Beck research on new Epilepsy medication (pg. 28) and Prof. Dr. Markus Nöthen research together with the International Psychiatric Genomics Consortium on genes connected to depression (pg 32)
Online copies are available available both as soft and hardcopies,Link to forsch
Each year in Lindau, Nobel Laureates meet with the next-generation of scientists, with the aim of fostering the exchange of knowledge between different generations and nationalities. The junior scientist comprise of undergraduates, postgraduates and postdocs. The annual meetings focus on three natural science disciplines, and alternatingly feature the field of physiology and medicine, physics or chemistry and once in five years a joint meeting of the disciplines. For many years now, the DFG has invited participants from China, Thailand and India to tour top research institutions in Germany on the so-called “Post-Lindau Tour”. This year’s meeting was dedicated to the field of physiology and medicine and thus on the list of top ranking research institutions in this field was the Faculty of Medicine at the University of Bonn.
About the Transregio
The SFB/TR is an interdisciplinary research network between the University of Bonn, the TU Dresden and the LMU Munich with participation of the University Marburg, the TU Munich and the MPI for Biochemistry Munich.
About the Science
Projects within the SFB/TR237 cover the diverse pathways involved in Nucleic Acid Immunity that have fundamental implications for human health and disease.
About the Candidates
The ideal candidates will be highly motivated and team oriented, with a strong interest in immunology and a first class academic degree in a life science related discipline.
PhD candidates: should have a Master's degree or equivalent for PhD positions, a strong background in molecular biomedicine, molecular biology, biochemistry or cell biology.
Postdoctoral candidates: should have an outstanding scientific track record including publications in peer reviewed journals.
As part of the events to celebrate its 200 years anniversary, the University of Bonn featured varies institutions and departments during the Open House at the Villa Hammerschmidt on Sunday, June 24, 2018. The event was visited by more than 14,000 people.
The Cluster Coordination office (CCO) and Cluster scientists from the Institute of Medical Microbiology Immunology and Parasitology (IMMIP) represented ImmunoSensation program during this event in the Tent "Global Health".
IMMIP Director Prof. Achim Hörauf and his team of scientists introduced the visitors into microscopy of successful worm treatment of filariasis patients, a group of neglected tropical diseases commonly known as elephantiasis and river blindness. The staff demonstrated how adult filarial worms are sterilized and killed by targeting endosymbiotic Wolbachia bacteria with the antibiotic doxycycline.
The Cluster Coordination Office had a long line of curious participants who wanted to play the role of immune cells and find out if through their sense of touch, they could identify the foreign object.
The immune-sensing game and microscopy were popular among all age groups.
The highlight of the our tent was a short visit by Germany's Federal President Frank-Walter Steinmeier. Prof. Hörauf introduced the Federal President into the current research of the Excellence Cluster and participating institutions. Watch the video of this memorable moment here.
A new publication by our Cluster member Prof. Heinz Beck shows, why the worldwide leading medication against epilepsy might not be suitable for a lot of patients.
The new findings published in the Journal of Neuroscience could lead to better and more effective therapies against epilepsy. This is of high importance since every third patient is not responding to the prescripted drugs these days.
The new Transregio 'Nucleic Acid Immunity' from the Unversity Bonn, TU Dresden and LMU Munich is funded by the DFG for a first round of 4 years from July 1st on.
Prof. Gunther Hartmann is the speaker of this consortium of researcher who will investigate the molecular mechanisms of recognizing foreign nucleic acids by our immune system.
This is of special importance since the malfunction of this system leads to various diseases such as chronic viral infections, inflammation and autoimmune disorders.
11 research groups of the medical faculty from the University Bonn are participating in this Transregio.