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ImmunoSensation - the immune sensory system

6th Venusberg Meeting on Neuroinflammation

May 09, 2019 - May 11, 2019

 

Neurodegeneration meets neuroinflammation: the mutual interactions between immune cells and neurons.
In this year's Venusberg Meeting on Neuroinflammation a special emphasis will be put on the interaction between neurodegenerative and neuroinflammatory mechanisms.
Speakers from all areas of neuroinflammation will present the most recent findings and developments in order to stimulate vivid and challenging discussions. More information on the program, venue and registration can be found at the website of the DZNE www.dzne.de/Venusbergmeeting2019
Date and Time:
9th May 2019 (9.00 a.m)  - 11 May 2019 (5.00 p.m)
Location:
DZNE Bonn,
Sigmund-Freud-Str. 27,
53127, Bonn

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Opening of the ImmunSinn Exhibition

April 23, 2019

 

ImmunSinn
An exhibition showing milestones in the field of immunology at the University of Bonn’s Museum from the 2nd of May to the 30th of June 2019

The exhibition titled ImmunSinn, is aimed at bringing immunology closer to the people covering the topics of immunotherapy, Alzheimer’s disease, the influence of western diet on our health, parasitic diseases and technological advances in immunology. On display are photos, 3D models, parasitic worms and informative posters that will take you from the 1860s to the present day.

The exhibition looks into some milestones in the field of immunotherapy, comparing the late 19th, the early 20th and the 21st centuries. We feature the first doctor who tried to harness the power of the immune system to fight cancer by using bacterial infection. Unknown to most people, he was a professor of surgery at the University Hospital Bonn. In 1867, Professor of Surgery, Carl David Wilhelm Busch, in his quest to cure a patient with an inoperable tumor of the neck, knowingly and purposefully exposed her to bacterial infection. This was after the observation that an episode of bacterial skin infection called erysipelas caused tumors to shrink. His treatment was at first successful and he was able to reduce the tumor size, but unfortunately, after a short while it grew back and the patient later succumbed to cancer. We also feature 21st century Busch-like immunotherapy, but more refined, this time using nucleic acids that mimic viral infections to induce a specific immune response that fights cancers.

During the late 19th century some doctors used live bacteria as a way to shrink and treat tumors. At that point in time, the knowledge on why and how this worked was not known. By the early 1900s, the use of live bacteria was replaced with its products. Since then, the field of immunology has grown and more information on host – pathogen interactions are now available. This has enabled scientists to move from directly using live bacteria organisms, to the production of specific molecules that are recognized by immune cells in the same way as pathogens. 

In developing countries, the most common causes of death are infectious diseases, while the developed nations have more lifestyle associated disease. As a representative disease of the western lifestyle, an atherosclerosis model is displayed which compares a healthy versus a clogged artery. For the developing world a collection of parasitic diseases that are endemic to the tropics and subtropics are displayed.
Prof. Schultze: “The exhibition looks into the developments that have taken place in the field of immunology over the last 100 years. It also gives a peak into the future, from using microscopes, like the 100 year old one on display, to the latest technology of single cell genomics”.

The exhibition has been put together by a team of scientists from ImmunuSensation2, like Dr. Anette Christ and Prof. Joachim Schultze (photographed at the exhibition), researcher from the Institute for Medical Humanities and compiled by Dr. Patricia Korir with support and advice from the speakers of the Cluster.

For those who would like to know more on specific topics in the exhibition, there will be public lectures inside the museum on the below listed topics and dates at 6 PM:

23rd May, Dr. Anette Christ, The effects of western diet on our health, Institute of Innate Immunity, University Hospital Bonn
6th June, Prof. Dr. med. Joachim Schultze, Single cell genomics: from one cell to the patient, LIMES, University of Bonn
13th June, Prof. Dr. med. Michael Heneka, Alzheimer’s disease, Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn University Hospital Bonn


Contact.
Dr. Patricia Jebett Korir
ImmunoSensation Cluster of Excellence, University of Bonn
Press and Public Relations
Venusberg - Campus 1, 53127 Bonn,
+49 228 287-51283
pkorir(at)uni-bonn.de

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PostDoc position available in Wilhelm Lab

April 15, 2019

 

An open PostDoc Position is available in the Wilhelm Lab in the Insitute of Clincal Chemistry and Clinical Pharmacology.
We are seeking a highly motivated postdoctoral fellow to conduct research on the fundamental aspects of nutritional regulation of the immune system. The Project aims to understand how different diets are able to shape the function of the immune system. In particular the work aims to identify how dietary-derived metabolites shape the biology of tissue resident immune cells such as innate lymphoid cells (ILC) in health and disease. The candidate will have opportunities to obtain additional external funding and develop an independent research program during postdoctoral training.
Find more information in the attached poster.

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Open PhD Positions

April 10, 2019

 

To find outstanding PhD students for the IITB program and the BIGS Immunoscience and Infection, we invite all interested students in our Selection Symposium. This will take place in May 2019 for the final round applicants. The Selection Symposium will include interviews with a Selection Committee, oral or poster presentations of the applicants and interviews with the PIs in whose labs postitions are available.
Please check our Recruitment Section for further information on how to apply.
Start of the PhD positions is planned for July 1, 2019 or later.

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Study for treatment of lymphatic filariosis in Science Translational Medicine published

March 15, 2019

 

Neglected tropical diseases such as Lymphatic filariosis are common in tropical and subtropical areas. Here mostly poor people are affected.
An international consortium with a contribution of scientists from the Cluster of Excellence ImmunoSensation identified a new substance ABBV-4083 in the fight against adult worms, the cause of lymphatic filariosis.
Dr. Marc Hübner and Prof. Hörauf are working in the Institute of Medical Microbiology, Immunology and Parasitology at the University Hospital Bonn.

You can find the german press release here.
Publication: Mark J. Taylor, Thomas W. von Geldern, Louise Ford, Marc P. Hübner, Kennan Marsh, Kelly L. Johnston, Hanna T. Sjoberg, Sabine Specht, Nicolas Pionnier, Hayley E. Tyrer, Rachel H. Clare, Darren A. N. Cook, Emma Murphy, Andrew Steven, John Archer, Dominique Bloemker, Franziska Lenz, Marianne Koschel, Alexandra Ehrens, Haelly M. Metuge, Valerinne C. Chunda, Patrick W. Ndongmo Chounna, Abdel J. Njouendou, Fanny F. Fombad, Robert Carr, Howard E. Morton, Ghaith Aljayyoussi, Achim Hoerauf, Samuel Wanji, Dale J. Kempf, Joseph D. Turner, Stephen A. Ward: Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis, Science Translational Medicine, DOI: 10.1126/scitranslmed.aau2086

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Apply for One-on-One Career Coaching

March 11, 2019

 

We are pleased to announce that female postdoctoral researchers and junior group leaders have the chance to apply for a fellowship for an One-on-One Career Coaching.


When: Starting in May


Where: Bonn (Humbroichweg 1A, 53227 Bonn) or via Skype


Topics:


  • Reflecting your own position and competences
  • Finding your own career strategy
  • Discussing your funding profile
  • Get feedback on your CV
  • and much more

You can decide the number and duration of your sessions (totalling to 10 hours).


!Take the chance to define your own career path!


Please send a letter of motivation, a description of your scientific work (needed for the coaching)  together with the completed application form to alexandra.kraemer@uni-bonn.de


Application deadline: April 05, 2019


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Open spots for DGfI Translational Immunology School 2019

March 04, 2019

 

Dear Cluster members and associated scientists,
We are pleased to announce that application for fellowships for the 8th DGfI Translational Immunology School 2019 is open! The fellowship covers the registration fee including courses, accommodation, full board and social program.
What? 8th DGfI Translational Immunology School 2019
When? April 11-13, 2019
Where? Potsdam
Further information you can find at https://dgfi.org/akademie-fuer-immunologie/translational-school/.
Application deadline: March 10, 2019
Applications will only be accepted via our eTraining system. To open your application, please send a short email to alexandra.kraemer@uni-bonn.de.

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Roger de Spoelberch Prize goes to Frank Bradke

January 31, 2019

 

Frank Bradke, a senior researcher at the German Center for Neurodegenerative Diseases (DZNE) and a professor at the University of Bonn, will be awarded the Roger de Spoelberch Prize, which is endowed with 750,000 euros. The Swiss Roger de Spoelberch Foundation thereby honors his studies on the growth and regeneration of neurons. Bradke’s research aims to lay the basis for novel therapies, especially for the treatment of spinal cord injuries. The award ceremony will be held in December 2019 in Geneva.

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ImmunoSensation scientists unravel a long standing enigma in crystal-induced chronic inflammation

December 19, 2018 - December 19, 2018

 

A team formed by researchers from the Institute of Innate Immunity, the Institute of Experimental Immunology of the University of Bonn, and the University of Massachusetts Medical School have unraveled a long standing enigma in crystal-induced chronic inflammation. 
It has been known, since 1850, that eosinophil infiltration into tissues results in the accumulation of large extracellular crystals known as Charcot-Leyden crystals (CLCs). CLCs have now been extensively described in the lungs of asthmatics patients as well as in patients with allergic reactions, helminthic infections and in the nose of chronic rhinosinusitis patients. Research on this topic has been considerably slow, for example, it took another 120 years for the biochemical characterization of these crystals, formed by a protein Galectin-10, which is enriched in eosinophil granules. Since then, another gap in knowledge was that their function or activity remained unknown. Whether these crystals are merely a marker of eosinophil demise, or play any role in the disease progression. 
The new study published this week in the Journal of Immunology shows that Charcot-Leyden crystals induce a strong inflammatory response driven by interleukin-1 after the activation of the pattern recognition receptor NLRP3 and formation of inflammasomes. The study suggests that a product of eosinophil degranulation can sustain immune activity, which could have important implications for the development of chronic diseases such as allergic asthma, a chronic airway inflammatory disease that affects 8-12% of people in Europe.

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Eva Bartok receives Universitätsgesellschaft Bonn (UGB) prize for outstanding doctoral thesis

December 05, 2018

 

 Dr. Eva Bartok from the Institute of Clinical Chemistry and Pharmacology was awarded the Universitätsgesellschaft Bonn (UGB) Bonner Preis für Medizin (Bonner Prize for Medicine) for her outstanding doctoral thesis in the field of medicine.  The prize which is sponsored by Prof. Dr. Rolf Dederich and the UGB has been awarded annualy since 2012 and carries a cash reward of 5000 euros.

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Alliance for Immunology between Bonn and Osaka

November 07, 2018

 

The University of Bonn and the University of Osaka, Japan have signed a five-year cooperation agreement. The agreement, which will feature academic and research collaboration between the Excellence Cluster, ImmunoSensation and University of Osaka’s Immunology Frontier Research Center (IFReC), Research Institute for Microbial Diseases (RIMD) and Graduate School of Frontier Biosciences (FBS), was signed on the 5th of November 2018 in Bonn.


Prof. Hoch lauded the cooperation as a new dawn for the two institutions and an opportunity to further understand the mechanism of the innate immunity. Addressing the scientists present at the occasion, the rector urged them to emulate Prof. Akira, who through his discovery and description of toll like receptor genes in mammals and their functions had influenced a generation of scientists and paved way for more research in the field.



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You can blame it on the gene! Researchers discover new gene for hair loss

November 06, 2018

 

In infancy, fine hair tends to sprout sparsely. With increasing age, hair loss progresses. Ultimately, only a few hairs are left on the head and body. Hypotrichosis simplex is a rare form of hair loss (alopecia). The condition is limited to a few hundred families worldwide. So far, only a few genes are known that are causally related to the disease. Under the leadership of the Institute of Human Genetics at the University Hospital of Bonn, a team of researchers from Germany and Switzerland have now deciphered mutations in another gene that is responsible for hair loss.
The scientists examined the coding genes of three families that are not related to each other and are of different ancestry. A total of eight relatives showed the typical symptoms of hair loss. All those affected had mutations in the LSS gene. “This gene encodes lanosterol synthase - LSS for short,” said Prof. Dr. Regina C. Betz from the Institute of Human Genetics at the University Hospital of Bonn. “The enzyme plays a key role in cholesterol metabolism.” However, the cholesterol blood values of those affected are not changed. Betz: “There is an alternative metabolic pathway for cholesterol, which plays an important role in the hair follicle and is not related to blood cholesterol levels."

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Six Excellence Clusters for the University of Bonn!!

September 27, 2018 - September 27, 2018

 

The much awaited Excellence Strategy funding decision by the DFG was received with cheers and applause! As the Rector of the University of Bonn, Prof. Michael Hoch, read the list of the 6 funded Excellence Clusters from the DFG website, the room was filled with joy and cheers!
ImmunoSensation² and 5 other Clusters were successful in their application. This was a significant moment, as the University of Bonn was the only University in Germany to receive funding for six Clusters of Excellence.  
We congratulate all ImmunoSensation scientists for their hard work and we look forward to achieving greater heights!!
We also congratulate: The Hausdorff Center for Mathematics, Beyond Slavery and Freedom, PhenoRob, ML4Q and ECONtribute!

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Current Trends in Digitalization of Medicine

September 26, 2018

 

Change in technology has brought with it convenience in the medical sector, with just a click of a button, patients and doctors have access to a lot of information. 
As part of the 200 years jubilee celebrations of the University of Bonn, Immunosensation together with the Medical Faculty organized an open lecture for the public on this topic. Prof. Nicolas Wernert  Dean of the Faculty of Medicine, gave a public lecture on the actual trends in the digitalization of medicine. His talk broadly covered actual tread starting from intergration of multi-omics, 3D printing of organs and tumors, standard Health-Apps on mobile phones to minimal invasive surgery using robotics. The lecture was directly followed by a podium discussion with experts in the fields related to it. 
The topic of digitalization is a sensitive one and with it alot of ethical and legal implications, therefore, to efficiently discuss this topic, the members of the panel consisted of experts from the legal sector, ethics, medical and private sector. Members of the podium were : Prof. Dr. Nicolas Wernert - Dean Faculty of Medicine, University of Bonn, Prof. Dr. Dr. Mariacarla Gadebusch Bondio – Director, Institute of Medical History, University Hospital Bonn, Katrin Reuter – Founder trackle GmbH, Prof. Dr. Markus Nöthen – Director, Institute of Human Genetics, University of Bonn and Prof. Dr. iur. Dirk Böhmann - Legal advisor for medical and labor laws, German Association of University Professors and Lecturers. The event was moderated by Jan Niklas Hansen, Doctoral candidate at the Institute of Innate Immunity, University of Bonn.

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Cluster Scientists Discover New Role of CCL17

September 12, 2018

 

ImmunoSensation Cluster scientists and associated members discover a new role for the allergy driver: It influences signal transmission in the brain.
The chemotactic protein CCL17 attracts immune cells to where they are currently needed. Doctors have long known: A high level of this substance in the body indicates an allergic reaction. A team of scientists led by the University of Bonn has now discovered a completely new function: CCL17 also influences signal transmission in the brain. There may even be a molecular link to autism. The results have now been published in the journal “GLIA”.
The article which they published in Glia is available online DOI: 10.1002/glia.23507


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PRINTEGER, Newsletter Edition 2/2018

August 31, 2018

 

Integrity in research is more of a necessity than a luxury and reseachers should alway perform their work with this in mind. PRINTEGER was a EU funded Project which came to an end on the 31st Aug 2018 and their mission was to enhance research integrity. During their project, Upright which is an interactive educational tool on research intergrity was developed.
Upright aims at promoting research intergrity with more the question " What kind of researcher should I be?" rather than "what should I do?". It also provides information and oppourtunities for debate and reflection. Intergrity in research is not a one off committment, but rather a lifelong one.


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ImmunoSensation and the Biomedicine Team Win the Excellence Science Slam!!

August 27, 2018

 


The two Excellence Clusters of the University of Bonn, ImmunoSensation and Hausdorff Center for Mathematics organized a joint Science- Slam that was held at the Arkadenhof of the University of Bonn. The slam also received support from the student iGEM-Team Bonn. 
The two teams went head to head, with each having 3 slammers from all over Germany that who presented on their respective disciplines. In the end, the public was charged with the task of determining the winner through casting of beads. And through a clear vote, measured  on measuring cylinders ImmunoSensation and its biomedicine team won. Roman Stilling who presented on microbiome was selected as the slammer of the night. 

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Cluster Scientist Nicole Glodde Wins Fleur Hiege- Prize 2018

August 24, 2018

 

Dr. Nicole Glodde from the Institute of Clinical Chemistry and Pharmacology, at the University Hospital Bonn has been selected for the Fleur Hiege-Gedächtnispreis 2018.

The 32-year-old postdoc in the Lab of Prof. Michael Hölzel, will receive the prize in recognition of her work in the field of cancer research that was published in Immunity, 2017. The publication entitled “Reactive neutrophil responses dependent on the receptor tyrosine kinase c-MET limit cancer immunotherapy”, demonstrated that neutrophils acquire immunosuppressive properties and inhibit the activity of killer immune cells, known as cytotoxic T cells, in the context of cancer immunotherapy. By elegantly performed experiments, Glodde and her colleagues discovered a way to counteract this mechanism and to increase the efficacy of cancer immunotherapy.
This is the second time that a cluster scientist has won this prestigious prize! in 2014, Tobias Bald received the same prize! Congratulations Nicole Glodde and the entire Prof. Hölzel lab!


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Immunosciences and Infection Takes 1st Position in NRW, DFG Funding Period 2014-2016

July 26, 2018

 

The efforts of Cluster scientists is very well reflected with the increase in funding, as shown by the DFG funding atlas. The DFG funding atlas for the period 2014 -2016 places us in 1st position in NRW and 3rd in the whole of Germany. During the 2014-2016 funding period, we received a total of 19.7 million euros, which was 3.4 million more than in 2011-2013 period.
The Medical Faculty was standing strong among the Top 10 in Germany (9 out of 85) having raised a total of 60.4 million euros. Neurosciences also moved up to position 7, having received a total of 16.3 million.
Congratulations for all the hard work!
Find the full press release here.

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forsch Uni-Bonn Features 3 Cluster Scientist in the Summer 2018 Edition

July 16, 2018

 

The forsch magazine is a publication of the University of Bonn featuring interesting and top ongoing research in various disciplines at the University. 
The 2018 summer edition featured articles from 3 cluster scientist:
Dr. Florian Schmidt on his Nanobodies research and their generation using Alpacas (pg. 22), Prof. Dr. Heinz Beck research on new Epilepsy medication (pg. 28) and Prof. Dr. Markus Nöthen research together with the International Psychiatric Genomics Consortium on genes connected to depression  (pg 32)
Online copies are available available both as soft and hardcopies,Link to forsch

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