More than 21 million people in Africa are infected with the nematode Onchocerca volvulus, the cause of river blindness. Around one in ten of those affected goes blind. Parasitologists around Prof. Hörauf at the University Hospital Bonn are looking for new, more effective weapons against the insidious parasite. The evaluation of the success of treatment is important. They now want to develop a method in which artificial intelligence (AI) automatically evaluates tissue samples from patients under the microscope. The aim is to reduce the time required and to establish an objective standard for analysis. The project is supported by the Bill & Melinda Gates Foundation.
Find the press release here.
Cluster member Prof. Bradke, who works at the German Center for Neurodegenerative Diseases (DZNE) and his group have identified a group of proteins that help to regenerate damaged nerve cells. Their findings are reported in the journal "Neuron".
It is commonly accepted that neurons of the central nervous system shut down their ability to grow when they no longer need it; this occurs normally after they have found their target cells and established synapses. However, recent findings show that old nerve cells have the potential to regrow and to repair damage similar to young neurons. The underlying mechanisms for this rejuvenation have now been uncovered in laboratory studies led by the team of Professor Frank Bradke at the DZNE's Bonn site together with scientists of the University of Bonn.
You can find the press release here.
Publication ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS. Andrea Tedeschi, Sebastian Dupraz, Michele Curcio, Claudia J. Laskowski, Barbara Schaffran et al. Neuron (2019). DOI: 10.1016/j.neuron.2019.07.007
Dear Cluster members and associated scientists,
We are pleased to announce that researchers have the chance to apply for a fellowship for the following conference in Berlin:
When? September 20 & 21, 2019
Where? Technische Universität Berlin
I, Scientist is a conference aimed at people in natural sciences, mathematics, engineering and computer science (life sciences: 28%).
- Introduces careers that exist in academia and beyond
- Addresses the gender-based marginalizations and barriers many people encounter in natural sciences
- Provides a variety of networking opportunities
Further information you can find here: https://www.iscientist.berlin/
The fellowship covers registration fee, travel costs and accomodation.
For application, please send an email including the completely filled registration form (attached), CV and a letter of motivation to email@example.com until August 05, 2019
We are looking forward to your application!
Our Cluster Member Prof. Andreas Zimmer from the Institute of Molecular Psychiatry gave an insight about using Cannabis in science.
You can find the radio spot here.
We are happy and proud to be part of that excellent University. The University of Bonn is one of only eleven Universities of Excellence in Germany appointed today and one of two in North Rhine-Westphalia. With the six Clusters of Excellence acquired last September, the University of Bonn is the most successful university in the Germany-wide Excellence competition.
We look forward to continue our excellent research in this excellent environment.
Find here the press release.
Our newest Cluster Time - Issue 8 is out.
In this edition of The Cluster Times we introduce the new members of the cluster and keep you updated with news from ImmunoSensation. Enjoy reading!
You can find our Newsletter here.
We are very happy to announce the opening of our family room at the BMZ. The opening ceremony was attended by Mrs. Kolits, a representative of the family service PME and Mrs Banavas from the office of gender equality of the UKB. The more than 40 guests had the opportunity to ask questions, exchange their experiences and have a look in our family room.
For our Cluster scientists, the family room can be used to provide childcare by the family service of PME when the regular daycare is closed due to unforeseen reasons. If you organize your own childcare- you can use it after booking the room at notes
If you have questions concerning the pme family service or the family room, please contact firstname.lastname@example.org
The SFB/Transregio "Aortic Diseases", will be working on basic and clinical research on expanding the understanding of fundamental principles in the pathogenesis of aortic diseases.
The SFB/Transregio "Cellular mechanisms of antibiotic action and production" intends to further investigate the biochemical production and action mechanisms of antibiotics.
More read the press release here
ImmunoSensation Scientist, Dr. Bernardo Franklin was feature in a Nature article titled "Europe is a top destination for many researchers". The article interviewed scientists from different parts of the world who are working in the EU.
“Science is not a recognized profession in Brazil, where I come from,” says Bernardo Franklin, an immunologist at the University of Bonn in Germany. “In Germany, PhD students are given working contracts, with regulations that provide them with insurances, pension and other benefits, and protect them from exploitation and abusive supervisors.”
Read the full article by clicking this link.
On the 29th of April 2019, Prof. Dr. Dr. h. c. Michael Hoch, Rector of the University of Bonn opened the exhibition Immun-Sinn at the University Museum of the University of Bonn. Immun-Sinn is an exhibition prepared by ImmunoSensation scientists and looks into the different aspects of immunology, starting with the history of immunotherapy, Alzheimer’s disease, influence of western diet on the immune system, tropical diseases and technological advancements in the field of immunology. The opening ceremony was attended by guests from different institutions in Bonn and also included PhD and Masters students. The exhibition will run from the 2nd of May till the 30th of June.
A TV spot about Cluster research conducted by the Institute of Innate Immunity (Prof. Eicke Latz and Dr. Anette Christ) can be found here:
It will provide you with information on how eating fast food will activate your immune system.
An exhibition showing milestones in the field of immunology at the University of Bonn’s Museum from the 2nd of May to the 30th of June 2019
The exhibition titled ImmunSinn, is aimed at bringing immunology closer to the people covering the topics of immunotherapy, Alzheimer’s disease, the influence of western diet on our health, parasitic diseases and technological advances in immunology. On display are photos, 3D models, parasitic worms and informative posters that will take you from the 1860s to the present day.
The exhibition looks into some milestones in the field of immunotherapy, comparing the late 19th, the early 20th and the 21st centuries. We feature the first doctor who tried to harness the power of the immune system to fight cancer by using bacterial infection. Unknown to most people, he was a professor of surgery at the University Hospital Bonn. In 1867, Professor of Surgery, Carl David Wilhelm Busch, in his quest to cure a patient with an inoperable tumor of the neck, knowingly and purposefully exposed her to bacterial infection. This was after the observation that an episode of bacterial skin infection called erysipelas caused tumors to shrink. His treatment was at first successful and he was able to reduce the tumor size, but unfortunately, after a short while it grew back and the patient later succumbed to cancer. We also feature 21st century Busch-like immunotherapy, but more refined, this time using nucleic acids that mimic viral infections to induce a specific immune response that fights cancers.
During the late 19th century some doctors used live bacteria as a way to shrink and treat tumors. At that point in time, the knowledge on why and how this worked was not known. By the early 1900s, the use of live bacteria was replaced with its products. Since then, the field of immunology has grown and more information on host – pathogen interactions are now available. This has enabled scientists to move from directly using live bacteria organisms, to the production of specific molecules that are recognized by immune cells in the same way as pathogens.
In developing countries, the most common causes of death are infectious diseases, while the developed nations have more lifestyle associated disease. As a representative disease of the western lifestyle, an atherosclerosis model is displayed which compares a healthy versus a clogged artery. For the developing world a collection of parasitic diseases that are endemic to the tropics and subtropics are displayed.
Prof. Schultze: “The exhibition looks into the developments that have taken place in the field of immunology over the last 100 years. It also gives a peak into the future, from using microscopes, like the 100 year old one on display, to the latest technology of single cell genomics”.
The exhibition has been put together by a team of scientists from ImmunuSensation2, like Dr. Anette Christ and Prof. Joachim Schultze (photographed at the exhibition), researcher from the Institute for Medical Humanities and compiled by Dr. Patricia Korir with support and advice from the speakers of the Cluster.
For those who would like to know more on specific topics in the exhibition, there will be public lectures inside the museum on the below listed topics and dates at 6 PM:
•23rd May, Dr. Anette Christ, The effects of western diet on our health, Institute of Innate Immunity, University Hospital Bonn
•6th June, Prof. Dr. med. Joachim Schultze, Single cell genomics: from one cell to the patient, LIMES, University of Bonn
•13th June, Prof. Dr. med. Michael Heneka, Alzheimer’s disease, Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn University Hospital Bonn
Dr. Patricia Jebett Korir
ImmunoSensation Cluster of Excellence, University of Bonn
Press and Public Relations
Venusberg - Campus 1, 53127 Bonn,
+49 228 287-51283
An open PostDoc Position is available in the Wilhelm Lab in the Insitute of Clincal Chemistry and Clinical Pharmacology.
We are seeking a highly motivated postdoctoral fellow to conduct research on the fundamental aspects of nutritional regulation of the immune system. The Project aims to understand how different diets are able to shape the function of the immune system. In particular the work aims to identify how dietary-derived metabolites shape the biology of tissue resident immune cells such as innate lymphoid cells (ILC) in health and disease. The candidate will have opportunities to obtain additional external funding and develop an independent research program during postdoctoral training.
Find more information in the attached poster.
To find outstanding PhD students for the IITB program and the BIGS Immunoscience and Infection, we invite all interested students in our Selection Symposium. This will take place in May 2019 for the final round applicants. The Selection Symposium will include interviews with a Selection Committee, oral or poster presentations of the applicants and interviews with the PIs in whose labs postitions are available.
Please check our Recruitment Section for further information on how to apply.
Start of the PhD positions is planned for July 1, 2019 or later.
Neglected tropical diseases such as Lymphatic filariosis are common in tropical and subtropical areas. Here mostly poor people are affected.
An international consortium with a contribution of scientists from the Cluster of Excellence ImmunoSensation identified a new substance ABBV-4083 in the fight against adult worms, the cause of lymphatic filariosis.
Dr. Marc Hübner and Prof. Hörauf are working in the Institute of Medical Microbiology, Immunology and Parasitology at the University Hospital Bonn.
You can find the german press release here.
Publication: Mark J. Taylor, Thomas W. von Geldern, Louise Ford, Marc P. Hübner, Kennan Marsh, Kelly L. Johnston, Hanna T. Sjoberg, Sabine Specht, Nicolas Pionnier, Hayley E. Tyrer, Rachel H. Clare, Darren A. N. Cook, Emma Murphy, Andrew Steven, John Archer, Dominique Bloemker, Franziska Lenz, Marianne Koschel, Alexandra Ehrens, Haelly M. Metuge, Valerinne C. Chunda, Patrick W. Ndongmo Chounna, Abdel J. Njouendou, Fanny F. Fombad, Robert Carr, Howard E. Morton, Ghaith Aljayyoussi, Achim Hoerauf, Samuel Wanji, Dale J. Kempf, Joseph D. Turner, Stephen A. Ward: Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis, Science Translational Medicine, DOI: 10.1126/scitranslmed.aau2086
We are pleased to announce that female postdoctoral researchers and junior group leaders have the chance to apply for a fellowship for an One-on-One Career Coaching.
When: Starting in May
Where: Bonn (Humbroichweg 1A, 53227 Bonn) or via Skype
- Reflecting your own position and competences
- Finding your own career strategy
- Discussing your funding profile
- Get feedback on your CV
- and much more
You can decide the number and duration of your sessions (totalling to 10 hours).
!Take the chance to define your own career path!
Please send a letter of motivation, a description of your scientific work (needed for the coaching) together with the completed application form to email@example.com
Application deadline: April 05, 2019
Dear Cluster members and associated scientists,
We are pleased to announce that application for fellowships for the 8th DGfI Translational Immunology School 2019 is open! The fellowship covers the registration fee including courses, accommodation, full board and social program.
What? 8th DGfI Translational Immunology School 2019
When? April 11-13, 2019
Further information you can find at https://dgfi.org/akademie-fuer-immunologie/translational-school/.
Application deadline: March 10, 2019
Applications will only be accepted via our eTraining system. To open your application, please send a short email to firstname.lastname@example.org.