Epilepsy: Function of "brake cells" disrupted

October 02, 2019

An interneuron (bright, with long appendages) from the hippocampus of the rat. The finely branched axon (top left cloud) surrounds the cell bodies of pyramidal cells and can inhibit these effectively. © Leonie Pothmann/Uni Bonn



In some forms of epilepsy, the function of certain "brake cells" in the brain is presumed to be disrupted. This may be one of the reasons why the electrical malfunction is able to spread from the point of origin across large parts of the brain. A current study by the University of Bonn with members of the cluster of excellence ImmunoSensation, in which researchers from Lisbon were also involved, points in this direction. The results are published in the renowned "Journal of Neuroscience".

Publication: Leonie Pothmann, Christian Klos, Oliver Braganza, Sarah Schmidt, Oihane Horno, Raoul-Martin Memmesheimer and Heinz Beck: Altered dynamics of canonical feed-back inhibition predicts increased burst transmission in chronic epilepsy; The Journal Of Neuroscience;  https://doi.org/10.1523/JNEUROSCI.2594-18.2019

Find the english press release here.