New method identifies aggressive breast cancer

October 30, 2019

During tumor development, macrophages (brown), the scavengers of the immune system, migrate into the diseased tissue (cancer cells: blue) without destroying it. © Karin E. de Visser/the Netherlands Cancer Institute

On the trail of aggressive breast cancer (from left): Prof. Dr. Joachim L. Schultze, Dr. Theodoros Kapellos and Dr. Thomas Ulas at the LIMES Institute of the University of Bonn. © Photo: Barbara Frommann/Uni Bonn


Aggressive forms of breast cancer often manipulate the immune response in their favor. This manipulation is revealed in humans by the same immunological "signature" as in mice. This is shown by a study carried out by scientists from the University of Bonn and memebers of the Cluster of Excellence ImmunoSensation together with Dutch colleagues. Their method makes it possible to obtain an indication of the prognosis of the disease using patients' tumor tissue. The results are published in the journal "Cell Reports".

Publication: Sander Tuit, Camilla Salvagno, Theodore S. Kapellos, Cheei-Sing Hau, Lea Seep, Marie Oestreich, Kathrin Klee, Karin E. de Visser, Thomas Ulas und Joachim L. Schultze: Transcriptional signature derived from murine tumor-associated macrophages correlates with poor outcome in breast cancer patients. Cell Reports; DOI: 10.1016/j.celrep.2019.09.067


Dr. Thomas Ulas
Head of the Bioinformatics Working Group
University of Bonn
Tel. +49-228-7362722