New Study published in Nature Methods

October 14, 2019
Picture of researchers

In the lab: (from left) Klaus Wunderling, Philipp Leyendecker and Prof. Dr. Christoph Thiele at the LIMES-Institute at the University of Bonn. © Photo: Barbara Frommann/Uni Bonn

Picture of liver cells

Picture of liver cells that are full of fat droplets (orange). The cell nuclei are shown in blue. © K. Piotrowitz/AG Thiele


Without fat, nothing works in the body: These substances serve as energy suppliers and important building blocks - including for the envelopes of living cells. Numerous diseases are related to disorders in the fat metabolism, such as obesity or cancer. Prof. Christoph Thiele from the LIMES Institute at the University of Bonn and member of the Cluster of Excellence ImmunoSensation and others are now demonstrating how the fat metabolism can be monitored down to the individual liver cell of a mouse with the greatest sensitivity. This opens up several possibilities, such as minimizing the side effects of new drugs on the fat metabolism. The scientists now present their study in the journal "Nature Methods".

You can find the english press release here.

Publication: Christoph Thiele, Klaus Wunderling, Philipp Leyendecker: Multiplexed and single cell tracing of lipid metabolism, Nature Methods, DOI: 10.1038/s41592-019-0593-6


Prof. Dr. Christoph ThieleUniversity of BonnLife & Medical Sciences Institute (LIMES)Tel. +49-228-7362818 E-mail: