Publication by Mass Group in Nature Neuroscience

February 11, 2020

Microscopic image of green stained macrophages after a stroke: The additional red stained cell (top right) originates from the bone marrow, the pure green cells are resident microglia. (c) AG Stumm/UKJ

Prof. Dr. Elvira Mass from the Life & Medical Sciences Institute (LIMES) and the Cluster of Excellence ImmunoSensation of the University of Bonn. © Photo: Silvia Hoch/Uni Bonn

 

Stroke: Macrophages migrate from the blood

Molecular switch in bone marrow stem cells helps research into inflammatory processes in the brain.

Macrophages are part of the innate immune system and essential for brain development and function. Using a novel method, scientists from Jena University Hospital, the Cluster of Excellence ImmunoSensation and the Memorial Sloan Kettering Cancer Center in New York (USA) succeeded in visualizing macrophages that were formed in the bone marrow. In studies on mice, this technology enabled the researchers to observe that shortly after a stroke, numerous macrophages that had migrated from the blood begin to attack dead and adjacent healthy brain tissue. The results have now been published in the journal "Nature Neuroscience". Prof. Elvira Mass - leading author of this publication - is a member of the Cluster of Excellence ImmunoSensation.

Find the press release here.

Publication: Yves Werner, Elvira Mass, Praveen Ashok Kumar, Thomas Ulas, Kristian Händler, Arik Horne, Kathrin Klee, Amelie Lupp, Dagmar Schütz, Friederike Saaber, Christoph Redecker, Joachim L. Schultze, Frederic Geissmann & Ralf Stumm: Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke, Nature Neuroscience, DOI: 10.1038/s41593-020-0585-y

Media contact:

Prof. Dr. Elvira Mass
Life & Medical Sciences Institute (LIMES)
Universität Bonn
Tel. +49-(0)228-7362848
E-mail: elvira.mass(at)uni-bonn.de