ImmunoSensation - the immune sensory system

1. Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2.
Ostendorf T, Zillinger T, Andryka K, Schlee-Guimaraes TM, Schmitz S, Marx S, Bayrak K, Linke R, Salgert S, Wegner J, Grasser T, Bauersachs S, Soltesz L, Hübner MP, Nastaly M, Coch C, Kettwig M, Roehl I, Henneke M, Hoerauf A, Barchet W, Gärtner J, Schlee M, Hartmann G, Bartok E
Immunity. 2020 Apr 14.
PMID: 32294405
2. The PNPLA3 I148M variant promotes lipid-induced hepatocyte secretion of CXC chemokines establishing a tumorigenic milieu.
Nischalke HD, Lutz P, Bartok E, Krämer B, Langhans B, Frizler R, Berg T, Hampe J, Buch S, Datz C, Stickel F, Hartmann G, Strassburg CP, Nattermann J, Spengler U
J Mol Med (Berl). 2019 Oct 21.
PMID: 31637480
3. BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages.
Chauhan D, Bartok E, Gaidt MM, Bock FJ, Herrmann J, Seeger JM, Broz P, Beckmann R, Kashkar H, Tait SWG, Müller R, Hornung V
Cell Rep. 2018 Nov 27.
PMID: 30485805
4. Direct RIG-I activation in human NK cells induces TRAIL-dependent cytotoxicity towards autologous melanoma cells.
Daßler-Plenker J, Paschen A, Putschli B, Rattay S, Schmitz S, Goldeck M, Bartok E, Hartmann G, Coch C
Int J Cancer. 2018 Sep 19.
PMID: 30230526
5. Activation of the NLRP3 Inflammasome by Hyaboron, a new Asymmetric Boron-Containing Macrodiolide from the Myxobacterium Hyalangium minutum.
Surup F, Chauhan D, Niggemann J, Bartok E, Herrmann J, Keck M, Zander W, Stadler M, Hornung V, Müller R
ACS Chem Biol. 2018 Sep 5.
PMID: 30183250
6. Type I interferon-mediated autoinflammation due to DNase II deficiency.
Rodero MP, Tesser A, Bartok E, Rice GI, Della Mina E, Depp M, Beitz B, Bondet V, Cagnard N, Duffy D, Dussiot M, Frémond ML, Gattorno M, Guillem F, Kitabayashi N, Porcheray F, Rieux-Laucat F, Seabra L, Uggenti C, Volpi S, Zeef LAH, Alyanakian MA, Beltrand J, Bianco AM, Boddaert N, Brouzes C, Candon S, Caorsi R, Charbit M, Fabre M, Faletra F, Girard M, Harroche A, Hartmann E, Lasne D, Marcuzzi A, Neven B, Nitschke P, Pascreau T, Pastore S, Picard C, Picco P, Piscianz E, Polak M, Quartier P, Rabant M, Stocco G, Taddio A, Uettwiller F, Valencic E, Vozzi D, Hartmann G, Barchet W, Hermine O, Bader-Meunier B, Tommasini A, Crow YJ
Nat Commun. 2017 Nov 19.
PMID: 29259162
7. G-rich DNA-induced stress response blocks type-I-IFN but not CXCL10 secretion in monocytes.
Herzner AM, Wolter S, Zillinger T, Schmitz S, Barchet W, Hartmann G, Bartok E, Schlee M
Sci Rep. 2016 Nov 12.
PMID: 27941826
8. An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice.
Ludwig-Portugall I, Bartok E, Dhana E, Evers BD, Primiano MJ, Hall JP, Franklin BS, Knolle PA, Hornung V, Hartmann G, Boor P, Latz E, Kurts C
Kidney Int. 2016 Jun 2.
PMID: 27262364
9. Measuring IL-1β Processing by Bioluminescence Sensors II: The iGLuc System.
Bartok E, Kampes M, Hornung V
Methods Mol Biol. 2016 May 25.
PMID: 27221484
10. Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA.
Herzner AM, Hagmann CA, Goldeck M, Wolter S, Kübler K, Wittmann S, Gramberg T, Andreeva L, Hopfner KP, Mertens C, Zillinger T, Jin T, Xiao TS, Bartok E, Coch C, Ackermann D, Hornung V, Ludwig J, Barchet W, Hartmann G, Schlee M
Nat Immunol. 2015 Sep 7.
PMID: 26343537
11. Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells.
Schmid-Burgk JL, Gaidt MM, Schmidt T, Ebert TS, Bartok E, Hornung V
Eur J Immunol. 2015 Aug 6.
PMID: 26174085
12. A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA.
Schuberth-Wagner C, Ludwig J, Bruder AK, Herzner AM, Zillinger T, Goldeck M, Schmidt T, Schmid-Burgk JL, Kerber R, Wolter S, Stümpel JP, Roth A, Bartok E, Drosten C, Coch C, Hornung V, Barchet W, Kümmerer BM, Hartmann G, Schlee M
Immunity. 2015 Jul 14.
PMID: 26187414
13. Immunoblotting for active caspase-1.
Jakobs C, Bartok E, Kubarenko A, Bauernfeind F, Hornung V
Methods Mol Biol. 2013 Jul 15.
PMID: 23852600
14. iGLuc: a luciferase-based inflammasome and protease activity reporter.
Bartok E, Bauernfeind F, Khaminets MG, Jakobs C, Monks B, Fitzgerald KA, Latz E, Hornung V
Nat Methods. 2013 Jan 6.
PMID: 23291722