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Cell Physiol Biochem. 2013 Jul 4.

A new model to perform electrophysiological studies in the early embryonic mouse heart.

Kornblum A, Pillekamp F, Matzkies M, Fleischmann B, Bonnemeier H, Schunkert H, Brockmeier K, Hescheler J, Reppel M

The first electrocardiograms (ECGs) have been recorded with a capillary electrometer in the late 19(th) century by John Burdon Sanderson and Augustus Waller. In 1903 Willem Einthoven used the much more sensitive string galvanometer and was awarded Nobel Price in Medicine for this discovery. Though the physical principles of that era are still in use, there have been many advances but also challenges in cardiac electrophysiology over the last decades. One challenge is to record electrocardiograms of rather small animals such as mice and even smaller organisms such as their embryos. As mice belong to the most routinely used laboratory animals it is important to better understand their physiology and specific diseases. We therefore aimed to study whether it is feasible to measure electrical activities of embryonic mouse hearts.

PMID: 23867719