ImmunoSensation - the immune sensory system

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Cardiovasc Res. 2019 May 22.

Aldosterone induces trained immunity: the role of fatty acid synthesis.

van der Heijden CDCC, Keating ST, Groh L, Joosten LAB, Netea MG, Riksen NP

Supranormal levels of aldosterone are associated with an increased cardiovascular risk in humans, and with accelerated atherosclerosis in animal models. Atherosclerosis is a low-grade inflammatory disorder, with monocyte-derived macrophages as major drivers of plaque formation. Monocytes can adopt a long-term pro-inflammatory phenotype after brief stimulation with microbial pathogens or endogenous atherogenic lipoproteins via a process termed trained immunity. In this study, we aimed to investigated whether aldosterone can induce trained immunity in primary human monocytes in vitro and explored the underlying mechanism.

PMID: 31119285