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EJNMMI Radiopharm Chem . 2020 Jul 29

Automated [ 18 F]PSMA-1007 production by a single use cassette-type synthesizer for clinical examination

Julia Sellin, Judith B Fülle, Christoph Thiele, Reinhard Bauer, Margret H Bülow, Sadahiro Naka, Tadashi Watabe, Kenta Kurimoto, Motohide Uemura, Fumihiko Soeda, Oliver C Neels, Klaus Kopka, Mitsuaki Tatsumi, Hiroki Kato, Norio Nonomura, Eku Shimosegawa, Jens Cardinale, Frederik L Giesel, Jun Hatazawa

Background: [18F]PSMA-1007, a positron emission tomography (PET) tracer, specifically targets prostate-specific membrane antigen (PSMA), which is highly expressed in prostate cancer. PSMA-PET is effective especially for regional detection of biochemical recurrence, which significantly affects patient management. Herein, we established and optimized a one-step radiolabeling protocol to separate and purify [18F]PSMA-1007 with a CFN-MPS200 synthesizer for clinical application.

PMID: 32728815