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J Thromb Haemost . 2020 May 7.

Bleeding symptoms in patients diagnosed as type 3 von Willebrand disease: Results from 3WINTERS-IPS, an international and collaborative cross-sectional study

Christian Kurts, Florent Ginhoux, Ulf Panzer, Elena Mitsi, Beatriz Carniel, Jesús Reiné, Jamie Rylance, Seher Zaidi, Alessandra Soares-Schanoski, Victoria Connor, Andrea M Collins, Andreas Schlitzer, Elissavet Nikolaou, Carla Solórzano, Sherin Pojar, Helen Hill, Angela D Hyder-Wright, Kondwani C Jambo, Marco R Oggioni, Megan De Ste Croix, Stephen B Gordon, Simon P Jochems, Daniela M Ferreira, Stephanie Fischinger, Jonathan K Fallon, Ashlin R Michell, Thomas Broge, Todd J Suscovich, Hendrik Streeck, Galit Alter, Laura Schaupp, Sabine Muth, Leif Rogell, Michael Kofoed-Branzk, Felix Melchior, Stefan Lienenklaus, Stephanie C Ganal-Vonarburg, Matthias Klein, Fabian Guendel, Tobias Hain, Kristian Schütze, Ulrike Grundmann, Vanessa Schmitt, Martina Dorsch, Julia Spanier, Pia-Katharina Larsen, Thomas Schwanz, Sven Jäckel, Christoph Reinhardt, Tobias Bopp, Sven Danckwardt, Karsten Mahnke, Gitta Anne Heinz, Mir-Farzin Mashreghi, Pawel Durek, Ulrich Kalinke, Oliver Kretz, Tobias B Huber, Siegfried Weiss, Christoph Wilhelm, Andrew J Macpherson, Hansjörg Schild, Andreas Diefenbach, Hans Christian Probst, Aglaja Kopf, Jörg Renkawitz, Robert Hauschild, Irute Girkontaite, Kerry Tedford, Jack Merrin, Oliver Thorn-Seshold, Dirk Trauner, Hans Häcker, Klaus-Dieter Fischer, Eva Kiermaier, Michael Sixt, Sonali Pechlivanis, Susanne Moebus, Nils Lehmann, Raimund Erbel, Amir A Mahabadi, Per Hoffmann, Karl-Heinz Jöckel, Markus M Nöthen, Hagen S Bachmann, Heinz Nixdorf Recall Study Investigative Group, Tobias J Weismüller, Taotao Zhou, Sandra Kalthoff, Henrike Lenzen, Michael P Manns, Christian P Strassburg, Alberto Tosetto, Zahra Badiee, Mohammad-Reza Baghaipour, Luciano Baronciani, Javier Battle, Erik Berntorp, Imre Bodó, Ulrich Budde, Giancarlo Castaman, Jeroen C J Eikenboom, Peyman Eshghi, Cosimo Ettorre, Anne Goodeve, Jenny Goudemand, Charles Richard Morris Hay, Hamid Hoorfar, Mehran Karimi, Bijan Keikhaei, Riitta Lassila, Frank W G Leebeek, Maria Fernanda Lopez Fernandez, Pier Mannuccio Mannucci, Maria Gabriella Mazzucconi, Massimo Morfini, Johannes Oldenburg, Ian Peake, Rafael Parra Lòpez, Flora Peyvandi, Reinhard Schneppenheim, Andreas Tiede, Gholamreza Toogeh, Marc Trossaert, Omidreza Zekavat, Eva M K Zetterberg, Augusto B Federici

Background: Type 3 von Willebrand's disease (VWD) patients present markedly reduced levels of von Willebrand factor and factor VIII. Because of its rarity, the bleeding phenotype of type 3 VWD is poorly described, as compared to type 1 VWD.

PMID: 32379400