ImmunoSensation - the immune sensory system

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J Infect Dis . 2020 Oct 10

Complement activation in the disease course of COVID-19 and its effects on clinical outcomes

Marco A Ataide, Karl Komander, Konrad Knöpper, Annika E Peters, Hao Wu, Sarah Eickhoff, Tea Gogishvili, Justus Weber, Anika Grafen, Axel Kallies, Natalio Garbi, Hermann Einsele, Michael Hudecek, Georg Gasteiger, Michael Hölzel, Martin Vaeth, Wolfgang Kastenmüller, Jishnu Das, Anush Devadhasan, Caitlyn Linde, Tom Broge, Jessica Sassic, Max Mangano, Sean O'Keefe, Todd Suscovich, Hendrik Streeck, Alivelu Irrinki, Chris Pohlmeyer, Gundula Min-Oo, Shu Lin, Joshua A Weiner, Thomas Cihlar, Margaret E Ackerman, Boris Julg, Steven Deeks, Douglas A Lauffenburger, Galit Alter, Georg Nickenig, Marcel Weber, Robert Schüler, Jörg Hausleiter, Michael Nabauer, Ralph Stephan von Bardeleben, Efthymios Sotiriou, Ulrich Schäfer, Florian Deuschl, Hannes Alessandrini, Felix Kreidel, Jean-Michel Juliard, Eric Brochet, Azeem Latib, Matteo Montorfano, Eustachio Agricola, Stephan Baldus, Kai P Friedrichs, Shekhar H Deo, Suzanne Y Gilmore, Ted Feldman, Rebecca T Hahn, Francesco Maisano, Aline H de Nooijer, Inge Grondman, Nico A F Janssen, Mihai G Netea, Loek Willems, Frank L van de Veerdonk, Evangelos J Giamarellos-Bourboulis, Erik J M Toonen, Leo A B Joosten

Background: Excessive activation of immune responses in coronavirus disease 2019 (COVID-19) is considered to be related to disease severity, complications and mortality. The complement system is an important component of innate immunity and can stimulate inflammation, but its role in COVID-19 is unknown.

PMID: 33038254