ImmunoSensation - the immune sensory system

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Mol Metab . 2020 May 30

Lack of Gα i2 proteins in adipocytes attenuates diet-induced obesity

Samira Imran, Melanie R Neeland, Rebecca Shepherd, Nicole Messina, Kirsten P Perrett, Mihai G Netea, Nigel Curtis, Richard Saffery, Boris Novakovic, Veronika Leiss, Annika Schönsiegel, Thorsten Gnad, Johannes Kerner, Jyotsna Kaur, Tina Sartorius, Jürgen Machann, Fritz Schick, Lutz Birnbaumer, Hans-Ulrich Häring, Alexander Pfeifer, Bernd Nürnberg

Objectives: Typically, obesity results from an inappropriate balance between energy uptake from nutrient consumption and burning of calories, which leads to a pathological increase in fat mass. Obesity is a major cause of insulin resistance and diabetes. Inhibitory G proteins (Gαi) form a subfamily that is involved in the regulation of adipose tissue function. Among the three Gαi members, i.e. Gαi1, Gαi2, Gαi3, the Gαi2, protein is predominantly expressed in adipose tissue. However, the functions of the Gαi2 isoform in adipose tissue and its impact on the development of obesity are poorly understood.

PMID: 32480042