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Alzheimers Res Ther . 2020 Oct 16

Neuropsychiatric symptoms in at-risk groups for AD dementia and their association with worry and AD biomarkers-results from the DELCODE study

Miguel J Lobo, Laia Reverte-Salisa, Ying-Chi Chao, Andreas Koschinski, Frank Gesellchen, Gunasekaran Subramaniam, He Jiang, Samuel Pace, Natasha Larcom, Ester Paolocci, Alexander Pfeifer, Sara Zanivan, Manuela Zaccolo, Helin Tercan, Niels P Riksen, Leo A B Joosten, Mihai G Netea, Siroon Bekkering, Maria Elisa Mancuso, Johnny Mahlangu, Robert Sidonio Jr, Peter Trask, Marianne Uguen, Tiffany Chang, Midori Shima, Guy Young, Johannes Oldenburg, Sylvia von Mackensen, Andreas Tiede, Santiago Bonanad, Amparo Santamaria, Georg Goldmann, Mariana Canaro, Antonio Palomero, Luis J G Frade, Juan Eduardo Megias-Vericat, Fernanda Martinez, Faustino Garcia Candel, Victor Jimenez Yuste, Monika Sparber-Sauer, Susan Halimeh, Daniela Adolf, Martin Hukauf, Jan Reichmann, Johannes Oldenburg, Artur Słomka, Tudor Mocan, Bingduo Wang, Iuliana Nenu, Sabine K Urban, Maria Gonzales-Carmona, Ingo G H Schmidt-Wolf, Veronika Lukacs-Kornek, Christian P Strassburg, Zeno Spârchez, Miroslaw Kornek, Hans-Peter Erasmus, Rukiye Bektas, Katharina Orland, Svetlozara Trifonova, Wen-Yi Gu, Frank Erhard Uschner, Maximilian J Brol, Johannes Chang, Michael Praktiknjo, Christian P Strassburg, Jonel Trebicka, Christian Jansen, Erik B van den Akker, Stella Trompet, Jurriaan J H Barkey Wolf, Marian Beekman, H Eka D Suchiman, Joris Deelen, Folkert W Asselbergs, Eric Boersma, Davy Cats, Petra M Elders, J Marianne Geleijnse, M Arfan Ikram, Margreet Kloppenburg, Haillang Mei, Ingrid Meulenbelt, Simon P Mooijaart, Rob G H H Nelissen, Mihai G Netea, Brenda W J H Penninx, Mariska Slofstra, Coen D A Stehouwer, Morris A Swertz, Charlotte E Teunissen, Gisela M Terwindt, Leen M 't Hart, Arn M J M van den Maagdenberg, Pim van der Harst, Iwan C C van der Horst, Carla J H van der Kallen, Marleen M J van Greevenbroek, W Erwin van Spil, Cisca Wijmenga, Alexandra Zhernakova, Aeilko H Zwinderman, Naveed Sattar, J Wouter Jukema, Cornelia M van Duijn, Dorret I Boomsma, Marcel J T Reinders, P Eline Slagboom, Narine Mesropyan, Patrick Kupczyk, Leona Dold, Tobias J Weismüller, Alois M Sprinkart, Burkhart Mädler, Claus C Pieper, Daniel Kuetting, Christian P Strassburg, Ulrike Attenberger, Julian A Luetkens, Laura K Esser, Vittorio Branchi, Sonia Leonardelli, Natalie Pelusi, Adrian G Simon, Niklas Klümper, Jörg Ellinger, Stefan Hauser, Maria A Gonzalez-Carmona, Manuel Ritter, Glen Kristiansen, Hubert Schorle, Michael Hölzel, Marieta I Toma, Cheryl Y Brown, Timothy Sadlon, Christopher M Hope, Ying Y Wong, Soon Wong, Ning Liu, Holly Withers, Katherine Brown, Veronika Bandara, Batjargal Gundsambuu, Stephen Pederson, James Breen, Sarah Anne Robertson, Alistair Forrest, Marc Beyer, Simon Charles Barry, Julia Böhme, Nuria Martinez, Shamin Li, Andrea Lee, Mardiana Marzuki, Anteneh Mehari Tizazu, David Ackart, Jessica Haugen Frenkel, Alexandra Todd, Ekta Lachmandas, Josephine Lum, Foo Shihui, Tze Pin Ng, Bernett Lee, Anis Larbi, Mihai G Netea, Randall Basaraba, Reinout van Crevel, Evan Newell, Hardy Kornfeld, Amit Singhal, Lena Sannemann, Ann-Katrin Schild, Slawek Altenstein, Claudia Bartels, Frederic Brosseron, Katharina Buerger, Nicoleta Carmen Cosma, Klaus Fliessbach, Silka Dawn Freiesleben, Wenzel Glanz, Michael T Heneka, Daniel Janowitz, Ingo Kilimann, Xenia Kobeleva, Christoph Laske, Coraline D Metzger, Matthias H J Munk, Robert Perneczky, Oliver Peters, Alexandra Polcher, Josef Priller, Boris Rauchmann, Christina Rösch, Janna Rudolph, Anja Schneider, Annika Spottke, Eike Jakob Spruth, Stefan Teipel, Ruth Vukovich, Michael Wagner, Jens Wiltfang, Steffen Wolfsgruber, Emrah Duezel, Frank Jessen, DELCODE Study Group

Background: Early identification of individuals at risk of dementia is mandatory to implement prevention strategies and design clinical trials that target early disease stages. Subjective cognitive decline (SCD) and neuropsychiatric symptoms (NPS) have been proposed as potential markers for early manifestation of Alzheimer's disease (AD). We aimed to investigate the frequency of NPS in SCD, in other at-risk groups, in healthy controls (CO), and in AD patients, and to test the association of NPS with AD biomarkers, with a particular focus on cognitively unimpaired participants with or without SCD-related worries.

PMID: 33066827