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JAMA Psychiatry . 2022 Jul 27

Quantifying Deviations of Brain Structure and Function in Major Depressive Disorder Across Neuroimaging Modalities

Nils R Winter, Ramona Leenings, Jan Ernsting, Kelvin Sarink, Lukas Fisch, Daniel Emden, Julian Blanke, Janik Goltermann, Nils Opel, Carlotta Barkhau, Susanne Meinert, Katharina Dohm, Jonathan Repple, Marco Mauritz, Marius Gruber, Elisabeth J Leehr, Dominik Grotegerd, Ronny Redlich, Andreas Jansen, Igor Nenadic, Markus M Nöthen, Andreas Forstner, Marcella Rietschel, Joachim Groß, Jochen Bauer, Walter Heindel, Till Andlauer, Simon B Eickhoff, Tilo Kircher, Udo Dannlowski, Tim Hahn

Importance: Identifying neurobiological differences between patients with major depressive disorder (MDD) and healthy individuals has been a mainstay of clinical neuroscience for decades. However, recent meta-analyses have raised concerns regarding the replicability and clinical relevance of brain alterations in depression.

PMID: 35895072