ImmunoSensation - the immune sensory system

Arterioscler Thromb Vasc Biol . 2020 Jul;40

Sex-Specific Regulation of Inflammation and Metabolic Syndrome in Obesity

Verena Rolfes, Lucas Secchim Ribeiro, Ibrahim Hawwari, Lisa Böttcher, Nathalia Rosero, Salie Maasewerd, Marina Lima Silva Santos, Tomasz Próchnicki, Camila Meirelles de Souza Silva, Carlos Wagner de Souza Wanderley, Maximilian Rothe, Susanne V Schmidt, H James Stunden, Damien Bertheloot, Magali Noval Rivas, Cor Jesus Fontes, Luzia Helena Carvalho, Fernando Queiroz Cunha, Eicke Latz, Moshe Arditi, Bernardo Simoes Franklin, Chao Yan, Stephane Koda, Jing Wu, Bei-Bei Zhang, Qian Yu, Mihai G Netea, Ren-Xian Tang, Kui-Yang Zheng, Rob Ter Horst, Inge C L van den Munckhof, Kiki Schraa, Raul Aguirre-Gamboa, Martin Jaeger, Sanne P Smeekens, Tessa Brand, Heidi Lemmers, Helga Dijkstra, Tessel E Galesloot, Jacqueline de Graaf, Ramnik J Xavier, Yang Li, Leo A B Joosten, Joost H W Rutten, Mihai G Netea, Niels P Riksen

Objective: Metabolic dysregulation and inflammation are important consequences of obesity and impact susceptibility to cardiovascular disease. Anti-inflammatory therapy in cardiovascular disease is being developed under the assumption that inflammatory pathways are identical in women and men, but it is not known if this is indeed the case. In this study, we assessed the sex-specific relation between inflammation and metabolic dysregulation in obesity. Approach and Results: Three hundred two individuals were included, half with a BMI 27 to 30 kg/m2 and half with a BMI>30 kg/m2, 45% were women. The presence of metabolic syndrome was assessed according to the National Cholesterol Education Program-ATPIII criteria, and inflammation was studied using circulating markers of inflammation, cell counts, and ex vivo cytokine production capacity of isolated immune cells. Additionally, lipidomic and metabolomic data were gathered, and subcutaneous fat biopsies were histologically assessed. Metabolic syndrome is associated with an increased inflammatory profile that profoundly differs between women and men: women with metabolic syndrome show a lower concentration of the anti-inflammatory adiponectin, whereas men show increased levels of several pro-inflammatory markers such as IL (interleukin)-6 and leptin. Adipose tissue inflammation showed similar sex-specific associations with these markers. Peripheral blood mononuclear cells isolated from men, but not women, with metabolic syndrome display enhanced cytokine production capacity.

PMID: 32460579