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Biol Chem . 2020 Oct 1;

The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes

Theophilos Tzaridis, Katrin S Reiners, Johannes Weller, Daniel Bachurski, Niklas Schäfer, Christina Schaub, Michael Hallek, Björn Scheffler, Martin Glas, Ulrich Herrlinger, Stefan Wild, Christoph Coch, Gunther Hartmann, Stephanie Fischinger, Sepideh Dolatshahi, Madeleine F Jennewein, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Nelson L Michael, Sandhya Vasan, Margaret E Ackerman, Hendrik Streeck, Galit Alter, Lianmin Chen, Inge C L van den Munckhof, Kiki Schraa, Rob Ter Horst, Martijn Koehorst, Martijn van Faassen, Claude van der Ley, Marwah Doestzada, Daria V Zhernakova, Alexander Kurilshikov, Vincent W Bloks, Albert K Groen, Human Functional Genomics Project, Niels P Riksen, Joost H W Rutten, Leo A B Joosten, Cisca Wijmenga, Alexandra Zhernakova, Mihai G Netea, Jingyuan Fu, Folkert Kuipers, Dominik Alterauge, Johannes W Bagnoli, Frank Dahlström, Barry M Bradford, Neil A Mabbott, Thorsten Buch, Wolfgang Enard, Dirk Baumjohann, Philipp Schult, Katrin Paeschke

DHX36 is a member of the DExD/H box helicase family, which comprises a large number of proteins involved in various cellular functions. Recently, the function of DHX36 in the regulation of G-quadruplexes (G4s) was demonstrated. G4s are alternative nucleic acid structures, which influence many cellular pathways on a transcriptional and post-transcriptional level. In this review we provide an overview of the current knowledge about DHX36 structure, substrate specificity and mechanism of action based on the available models and crystal structures. Moreover, we outline its multiple functions in cellular homeostasis, immunity, and disease. Finally, we discuss the open questions and provide potential directions for future research.

PMID: 33021960