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Curr Opin Immunol . 2020 Jun 1;

The fibroblastic T cell niche in lymphoid tissues

Vittorio Branchi, Tobias J Weismüller, Taotao Zhou, Jonas Henn, Alexander Semaan, Tim R Glowka, Maria Gonzalez-Carmona, Christian Strassburg, Jörg C Kalff, Steffen Manekeller, Hanno Matthaei, Hiroki Kato, Hideo Nagatomo, Mitsuo Nakai, Tatsuhiro Sakaiya, Hidenori Terasaki, Tadashi Kondo, Yoichiro Hironaka, Katsuya Shimizu, Keisuke Shigemori, Nasim Shahidi Hamedani, Jens Müller, Fabian Tolle, Heiko Rühl, Behnaz Pezeshkpoor, Kerstin Liphardt, Johannes Oldenburg, Günter Mayer, Bernd Pötzsch, Evelyn Gaffal, Andrea M Kemter, Stefanie Scheu, Rafael Leite Dantas, Jens Vogt, Bernhard Baune, Thomas Tüting, Andreas Zimmer, Judith Alferink, Florian Langer, Stefan Kluge, Robert Klamroth, Johannes Oldenburg, Anne L Fletcher, Alfie T Baker, Veronika Lukacs-Kornek, Konstantin Knoblich

Fibroblastic reticular cells (FRCs) are a necessary immunological component for T cell health. These myofibroblasts are specialized for immune cell support and develop in locations where T and B lymphocyte priming occurs, usually secondary lymphoid organs, but also tertiary lymphoid structures and sites of chronic inflammation. This review describes their dual supportive and suppressive functions and emerging evidence on the co-ordination required to balance these competing roles.

PMID: 32497868