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Clin Microbiol Infect. 2019 Feb 23.

Trained innate immunity and resistance to Mycobacterium tuberculosis infection.

Koeken VA, Verrall AJ, Netea MG, Hill PC, van Crevel R

Some individuals, even when heavily exposed to an infectious tuberculosis patient, develop neither active nor latent tuberculosis infection (LTBI). This 'early clearance' of Mycobacterium tuberculosis is associated with a history of bacillus Calmette-Guérin (BCG) vaccination. As BCG vaccination can boost innate immune responses through a process termed 'trained immunity', we hypothesize that BCG-induced trained innate immunity contributes to early clearance of M. tuberculosis.

PMID: 30807849