The immune system’s challenge: Correctly identifying pathogens and dangers to the host

Here, we aim to decipher the precise molecular principles underlying the detection and integration of information allowing the immune system to distinguish dyshomeostatic from homeostatic states in tissues and to effectively yet appropriately respond to danger and threats.

A thematic overview of the four key areas sensing of modified self, systems analysis of inflammasome activation, intestinal chemosensing and neuro-immune crosstalk, and immune modulation in CNS excitability in health and disease is provided in the following figure.