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Dr. Matthias Becker

Member

German Center for Neurodegenerative Diseases (DZNE)

Venusberg-Campus 1, 53127 Bonn

matthias.becker@dzne.de

+49 228 43302642

Our research focus is on development and application of generative AI. We use it to generate high quality synthetic cohort omics data for privacy-preserving data sharing in collaborations and demonstrate it in the classification of patients in Alzheimer’s diseases. Another development is DrugDiff, our diffusion model for the generation of novel small molecules with specific molecular properties. To make these approaches feasible, we use and investigate modular high-performance computing techniques.

Dr. Matthias Becker

Recent publications

  • ConvexGating infers gating strategies from clusters in single cell cytometry data.

    Nature communications

    Authors: Vincent D Friedrich, Karola Mai, Thomas P Hofer, Elfriede Nößner, Lorenzo Bonaguro, Celia L Hartmann, Aleksej Frolov, Caterina Carraro, Doaa Hamada, Mehrnoush Hadaddzadeh Shakiba, Heidi Theis, Dalila Juliana Silva Ribeiro, Dagmar Wachten, F Thomas Wunderlich, Markus Scholz, Fabian J Theis, Matthias Becker, Marc D Beyer, Joachim L Schultze, Maren Büttner

  • TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism.

    Nature communications

    Authors: Astrid F Feiten, Kilian Dahm, Kai Schlepckow, Bettina van Lengerich, Jung H Suh, Anika Reifschneider, Benedikt Wefers, Laura M Bartos, Karin Wind-Mark, Lis de Weerd, Thomas Ulas, Elena De-Domenico, Pia Grundschöttel, Stefan Paulusch, Benjamin Tast, Tamisa Honda, Stephan A Müller, Matthias Becker, Igor Khalin, Alessio Ricci, Arthur Liesz, Bettina Brunner, Claudia Krenner, Katrin Buschmann, Brigitte Nuscher, Lena Spieth, Niklas Junker, Stefan A Berghoff, Sonnet S Davis, Jonas J Neher, Wolfgang Wurst, Nikolaus Plesnila, Joseph W Lewcock, Mikael Simons, Stefan F Lichtenthaler, Gilbert Di Paolo, Matthias Brendel, Anja Capell, Kathryn M Monroe, Joachim L Schultze, Christian Haass

  • Kupffer cells control neonatal hepatic metabolism via Igf1 signaling.

    Development (Cambridge, England)

    Authors: Nikola Makdissi, Daria Hirschmann, Aleksej Frolov, Inaam Sado, Bastian Bennühr, Fabian Nikolka, Jingyuan Cheng, Nelli Blank-Stein, Maria Francesca Viola, Mohamed Yaghmour, Philipp Arnold, Lorenzo Bonaguro, Matthias Becker, Christoph Thiele, Felix Meissner, Karsten Hiller, Marc D Beyer, Elvira Mass

All publications by Dr. Matthias Becker