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Dr. Matthias Becker

Member

German Center for Neurodegenerative Diseases (DZNE)

Venusberg-Campus 1, 53127 Bonn

matthias.becker@dzne.de

+49 228 43302642

Our research focus is on development and application of generative AI. We use it to generate high quality synthetic cohort omics data for privacy-preserving data sharing in collaborations and demonstrate it in the classification of patients in Alzheimer’s diseases. Another development is DrugDiff, our diffusion model for the generation of novel small molecules with specific molecular properties. To make these approaches feasible, we use and investigate modular high-performance computing techniques.

Dr. Matthias Becker

Recent publications

  • BBS8-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue.

    The EMBO journal

    Authors: Katharina Sieckmann, Nora Winnerling, Dalila Juliana Silva Ribeiro, Seniz Yüksel, Ronja Kardinal, Lisa Maria Steinheuer, Fabian Frechen, Luis Henrique Corrêa, Geza Schermann, Christina Klausen, Nelli Blank-Stein, Jonas Schulte-Schrepping, Collins Osei-Sarpong, Matthias Becker, Lorenzo Bonaguro, Marc Beyer, Helen Louise May-Simera, Jelena Zurkovic, Christoph Thiele, Kevin Thurley, Lydia Sorokin, Carmen Ruiz de Almodovar, Elvira Mass, Dagmar Wachten

  • Oxidative phosphorylation is a key feature of neonatal monocyte immunometabolism promoting myeloid differentiation after birth.

    Nature communications

    Authors: Greta Ehlers, Annika Marie Tödtmann, Lisa Holsten, Maike Willers, Julia Heckmann, Jennifer Schöning, Maximilian Richter, Anna Sophie Heinemann, Sabine Pirr, Alexander Heinz, Christian Dopfer, Kristian Händler, Matthias Becker, Johanna Büchel, Achim Wöckel, Constantin von Kaisenberg, Gesine Hansen, Karsten Hiller, Joachim L Schultze, Christoph Härtel, Wolfgang Kastenmüller, Martin Vaeth, Thomas Ulas, Dorothee Viemann

  • DrugDiff: small molecule diffusion model with flexible guidance towards molecular properties.

    Journal of cheminformatics

    Authors: Marie Oestreich, Erinc Merdivan, Michael Lee, Joachim L Schultze, Marie Piraud, Matthias Becker

All publications by Dr. Matthias Becker