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PhD students in the lab

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PhD student (m/w/d) in T cell immunology/immune regulation

The University Hospital Bonn (UKB) is a maximum care hospital with more than 1,300 beds. Our more than 9,000 employees perform tasks in research, teaching and patient care as well as in public health care at the highest level. In the science ranking (LOMV) and in the economic result, the UKB ranks first among university hospitals in NRW and had the third highest case-mix index of university hospitals in Germany in 2021.

The Medical Clinic III at the University Hospital Bonn has the following full-time position available as soon as possible:


PhD student (m/w/d) in T cell immunology/immune regulation in allogeneic stem cell transplantation and cellular immunotherapy



The position is initially project-related and limited to 3 years with the prospect of an extension of the employment.


Our "Laboratory for Experimental Stem Cell Transplantation and Cellular Therapy" focuses on basic and translational research assessing humoral and cellular immunoregulatory mechanisms during allogeneic stem cell transplantation and other cellular immunotherapies, mainly CAR T cells. Furthermore, we assess the impact of dietary habits on the immune function during those cell therapies. In addition, using nanobody technology we aim to identify new treatment options for malignant diseases.


Qa-1 restricted CD8+ regulatory T cells (Treg) are a newly identified T cell population in mice that play a major role in regulating immune responses in autoimmunity, infection and cancer. Recent analyses have defined thorough phenotypical and functional characteristics of this CD8+ T cell subset. However, the functional human homologue of Qa-1 restricted CD8+ Treg could not yet be established.

In this project, our laboratory seeks to further assess the role of murine CD8+ Treg in various disease models and additionally focuses on the identification of the human homologue of murine CD8+ Treg. We use the knowledge recently gained from murine experiments to define human HLA-E restricted CD8+ Treg and close collaborations with the Department of Hematology and Oncology of the University Hospital Bonn allow the assessment of this CD8+ T cell subset in human disease.


Your responsibilities:

- Cell culture and extraction of primary immune cells
- Biobanking
- Molecular biology (PCR, gel electrophoresis, RNA and DNA extraction, qPCR)
- FACS analyses
- Immunohistochemistry
- - Metabolic assays
Work with mice (breeding, genotyping, nutritional studies, transfer experiments)


Your profile:

We are looking for a highly motivated and talented PhD student with high interest in T cell immunology.

Your profile should include:

- Strong work commitment and discipline
- Diploma or master thesis in immunology, biology, biochemistry, biomedicine or similar
- Ability to work independently and as part of a team
- Good English communication skills



We offer:

- Dynamic, multidisciplinary and international environment with a strong focus on immunology.
- International Immunology Training Program, giving access to state-of-the-art training and workshops on different scientific aspects
- Weekly seminars on immunology and other biomedical topics by national and international speakers
- Possibility to present results at national and international conferences.
- Modern university sport facilities
- Salary according to the German scale TV-L 13 65% with additional benefits in the public sector such as pension plan and - - UKB corporate benefits
- Living in an active university city with access to internationally known museums, music and theatre venues and many other cultural possibilities in the Bonn-Cologne area


The University of Bonn is a German University of Excellence since 2019 that is committed to affirmative action for diversity and equal opportunities for all. Applications will be handled in accordance with the Landesgleichstellungsgesetz (State Equality Act). Applications from suitable persons with a proven severe disability and persons with equivalent status are particularly welcome.


Contact:

Applications (in German or English) are considered by email including a CV and the necessary certificates. Additionally, a brief statement of motivation should be attached.

Dr. med Tobias Holderried

Medizinische Klinik III
Labor für experimentelle Stammzelltransplantation und zelluläre Immuntherapie
Universitätsklinikum Bonn
Venusberg-Campus 1 53127 Bonn

Tel.: +49 228 287 17233

E-Mail: tobias.holderried@ukbonn.de

Postdoctoral Scientist Immune diversity and Brain Health (f/m/x)

The German Center for Neurodegenerative Diseases (DZNE) is a world-leading internationally oriented research center, committed to discovering new approaches to prevent and treat neurodegenerative diseases. To this end, researchers at ten DZNE sites across Germany pursue a translational and interdisciplinary strategy comprising five interconnected areas: fundamental research, clinical research, health care research, population health science, and systems medicine. www.dzne.de

Postdoctoral Scientist Immune diversity and Brain Health (f/m/x)


Code: 1306/2024/4

We are looking for an ambitious researcher with experience with immunology and a keen interest in large scale data analyses to join our Population Health Sciences group at the German Center for Neurodegenerative Diseases (DZNE) in Bonn.

We investigate causes and biomarkers of neurodegenerative and other ageing related disorders, with the ultimate goal of enabling personalized disease prevention. Our research is primarily based on the Rhineland Study, a prospective cohort study that emphasizes deep phenotyping. The study currently includes more than 11.000 participants at baseline, follow-up data is already available from nearly 5.000 participants, and further data collection is ongoing. Available clinical data include detailed structural and functional brain imaging, cognitive and neurological assessments, cardiovascular and anthropometric assessments, sensory systems tests, and medical history and medication use data. Available multi-omics data, both from baseline and follow-up, include (epi) genomic, transcriptomic, metabolomic, lipidomic, proteomic and microbiome data. A special research focus is on the role of the immune system in health and disease. To this end, we also included FACS analyses, immune stimulation assays and extensive cytokine profiling into our core protocols. We collaborate with multiple partners at Bonn University in the Cluster of Excellence “Immunosensation” and the Collaborative Research Center “Metaflammation”.

Your tasks

In addition to contributing to ongoing projects, you will lead and develop your own research projects aligned with our group's research interests. This includes conducting and overseeing experiments in the laboratory, analyzing data, and preparing publications for peer-reviewed journals. Furthermore, you will actively participate in national and international conferences and engage with the scientific community. You will have the opportunity to supervise PhD and master's students and – if desired – to be involved in teaching.

Requirements

The ideal candidate will have a strong track record of excellence in research, outstanding analytical and communication skills, and a demonstrated ability to work collaboratively in a dynamic team-oriented environment. If you are passionate about making meaningful contributions to the field of non-communicable diseases and immunology, we encourage you to apply.

We offer

The position is initially limited to three years with the possibility of extension. We are looking for motivated individuals to help us address pressing health issues related to aging. As a member of our highly interdisciplinary and international team, you will have access to excellent scientific infrastructure with state-of-the-art research and computational facilities. You will have excellent publication opportunities and great potential for the further development of your own research profile. We actively encourage and support personal development, and offer employment, payment, and social benefits that are in line with other leading research institutes.

How to apply

Interested applicants should submit, as one single PDF file, a CV, transcripts, 3 references, and a cover letter describing your motivation to apply for this position, including research interest and experience, through the following link below

Review of applications will begin immediately and continue until the position is filled.

For inquiries about the position, please contact Prof Dr Dr Monique Breteler at population-research@dzne.de

2 PhD positions in Molecular Immunology

The research group of Prof. Florian I. Schmidt at the Institute of Innate Immunity of the University of Bonn is currently offering immediately (or as soon aspossible)


2 PhD positions in Molecular Immunology


The Schmidt lab takes an entirely novel approach to study the cell biology of the innate immune system: We generate custom-made nanobodies to interfere with and to visualize the activation of antiviral signaling pathways in highly specific ways. Our tools render the fascinating signaling complexes of the innate immune system accessible to systematic analysis in an unprecedented way. In the upcoming projects, we aim to elucidate the molecular mechanisms of gasdermin pore formation, including fundamental research and potential novel therapeutic avenues. Upcoming research projects will define pathways that negatively regulate inflammation. We address mechanistic questions from multiple perspectives using cell biological, biochemical, immunological, and virological approaches in combination with advanced imaging techniques and protein engineering.


We offer:


• Challenging projects at the interface of cell biology, immunology, and virology


• A stimulating, multidisciplinary research environment in the Cluster of Excellence ‘ImmunoSensation2’ and the Institute of Innate Immunity at the University of Bonn


• Salary will be according to the German salary scale TV-L


• Graduate students will be integrated into the ‘International Immunology Training Program Bonn’ (IITB)


Our requirements:


• Enthusiasm for research in a collaborative environment


• Strong interest in solving fundamental or applied biological problems


• Commitment to the research project


• Experience in cell biology, biochemistry, immunology, and/or virology (Master or equivalent)


• Excellent degrees and track record


• Very good communication skills (English)


Application


• The University of Bonn is an equal opportunity employer.


• Full applications should include a brief statement on research interests, a CV, list of publications (if applicable), and contact information for two referees, compiled into a single pdf file.


• Please contact Florian I. Schmidt (fschmidt@uni-bonn.de) for further information.

Postdoctoral researcher (100%, TVL13) position in Spatial immunology of the Epididymis

The Rheinische Friedrich-Wilhelms-Universität Bonn is an international research university that offers a wide range of degree programs. With 200 years of history, about 38,000 students, over 6.000 employees, and an excellent domestic and international reputation, Bonn University is among Germany’s leading universities.

The Schlitzer Lab is looking for a highly motivated postdoc investigating mononuclear phagocytes' development and functional specialization during acute and chronic inflammation in the murine epididymis using state-of-the-art single-cell technologies. Starting at the earliest date possible for 3 years initially, this position will be integrated into the newly established DFG-funded research Unit INFINITE on epididymal Immunology, the Cluster of Excellence Immunosensation2, and the PRECISE platform of the University of Bonn, and the German Center for Neurodegenerative, diseases.


The Schlitzer Lab at the Life and Medical Sciences Institute (https://bit.ly/2RXDH0M) integrates spatial single-cell OMICS, high-dimensional imaging, and flow cytometry to unravel novel mechanisms and regulatory circuits during the functional specialization and development of mononuclear phagocytes.


1 Postdoctoral researcher (100%, TVL13) position in Spatial immunology of the Epididymis



Your profile:

• PhD degree in biomedical sciences, biology, bioinformatics, or a similar subject


• Strong background in immunology


• Strong background in Imaging or Spatial transcriptomics technologies


• Knowledge of flow cytometry


• Knowledge of the programming language R or Phyton


• excellent command of the English language


• motivated, flexible, team oriented and interested in continued professional development.


We offer:

• a varied and challenging position in a thriving academic environment


• access to state-of-the-art spatial single cell biology methods


• embedding with an established cluster of excellence in Immunology and a


newly established Research unit on epididymal Immunology


• a professional career development program


• participation in the university-wide pension system (VBL)


• access to the extensive university sports program


• a salary based on the TV-L scale


The University of Bonn is committed to diversity and equal opportunity. It is certified as a family-friendly university and aims to increase the proportion of women employed in areas where women are underrepresented and to promote their careers. To that end, it urges women with relevant qualifications to apply. Applications will be handled in accordance with the Landesgleichstellungsgesetz (State Equality Act). Applications from suitable candidates with a certified disability or equivalent status are welcome.


If you are interested in this position, please send your complete application documents by 17.05.2024 to andreas.schlitzer@uni-bonn.de with the application code INFINITE/Bonn/Schlitzer. A full application should consist of a CV, a one-page summary of your previous work, and the contact details of two referees. Before sending your application, please combine and convert all of your documents into one PDF file.

For further information, please contact Andreas Schlitzer (Tel.: 0228/7362847).

Doctoral student (65%, TVL13) position in Spatial immunology of the Epididymis

The Rheinische Friedrich-Wilhelms-Universität Bonn is an international research university that offers a wide range of degree programs. With 200 years of history, about 38,000 students, over 6.000 employees, and an excellent domestic and international reputation, Bonn University is among Germany’s leadinguniversities.

The Schlitzer Lab is looking for a highly motivated doctoral student investigating mononuclear phagocytes' development and functional specialization during acute and chronic inflammation in the murine epididymis using state-of-the-art single-cell technologies. Starting at the earliest date possible for 3 years initially, this position will be integrated into the newly established DFG-funded research Unit INFINITE on epididymal Immunology, the Cluster of Excellence Immunosensation2, and the PRECISE platform of the University of Bonn, and the German Center for Neurodegenerative, diseases.


The Schlitzer Lab at the Life and Medical Sciences Institute (https://bit.ly/2RXDH0M) integrates spatial single-cell OMICS, high-dimensional imaging, and flow cytometry to unravel novel mechanisms and regulatory circuits during the functional specialization and development of mononuclear phagocytes.


1 Doctoral student (65%, TVL13) position in Spatial immunology of the Epididymis



Your profile:

• Master degree in biomedical sciences, biology, bioinformatics, or a similar subject


• Background in Immunology


• Background in Imaging or Spatial transcriptomics technologies


• Willingness to work with animals


• Knowledge of flow cytometry


• Knowledge of the programming language R or Phyton


• excellent command of the English language


• motivated, flexible, team oriented and interested in continued professional development.


We offer:

• a varied and challenging position in a thriving academic environment


• access to state-of-the-art spatial single cell biology methods


• embedding with an established cluster of excellence in Immunology and a newly established Research unit on epididymal Immunology


• Integration into the graduate school of the Cluster of Excellence Immunosensation2


• a professional career development program


• participation in the university-wide pension system (VBL)


• access to the extensive university sports program


• a salary based on the TV-L scale


The University of Bonn is committed to diversity and equal opportunity. It is certified as a family-friendly university and aims to increase the proportion of women employed in areas where women are underrepresented and to promote their careers. To that end, it urges women with relevant qualifications to apply. Applications will be handled in accordance with the Landesgleichstellungsgesetz (State Equality Act). Applications from suitable candidates with a certified disability or equivalent status are welcome.


If you are interested in this position, please send your complete application documents by 17.05.2024 to andreas.schlitzer@uni-bonn.de with the application code INFINITE/Bonn/Schlitzer. A full application should consist of a CV, a one-page summary of your previous work, and the contact details of two referees. Before sending your application, please combine and convert all of your documents into one PDF file. For further information, please contact Andreas Schlitzer (Tel.: 0228/7362847).

PhD position – Mucosal Immunology and microbiota research (m/f/o)

Available immediately for three years with the possibility of extension.


A PhD position is available to study the intestinal antibody response to the microbiota. Therefore, we will employ single B cell immunoglobulin gene sequencing, sequence-guided gene synthesis, monoclonal antibody production, antibody binding assays, germ-free, and gnotobiotic mouse models, in vivo bacterial transcriptomics, and single cell host transcriptomic analysis. Our aim is to obtain a detailed mechanistic understanding of the effects of Immunoglobulin A on the bacterial target cell and the host immune system.


For related previous work see the following links:

https://www.nature.com/articles/s41586-021-03973-7

https://www.nature.com/articles/s41590-018-0106-2


We offer:

The University of Bonn is a German University of Excellence since 2019. The medical faculty is a hub for internationally recognised immunological institutes and part of the Immunosensation2 cluster of excellence in Germany (www.immunosensation.com). The Department of Mucosal Immunology is newly founded within the Institute of Molecular Medicine and Experimental Immunology (www.immei.de).

- Excellent working conditions and competitive remuneration.

- Dynamic, multidisciplinary, and international setting with strong immunology focus.

- To become part of the Graduate school with additional workshops, lectures, networking events and conferences (www.bigs-immuno.uni-bonn.de)

- Participation in national and international conferences.

- The possibility to apply for the internal slots of International School on Advanced Immunology.

- Living in an active university city with access to many cultural possibilities.

- Salary according to the German TV-L13 65% and additional benefits such as a pension plan.

- Although the position is fully funded, we fully support your applications for career advancement grants or PhD research fellowships.

- Possibility to co-supervise undergraduate students or technicians

- Close supervision in regular meetings

- State of the art equipment and scientific methods to answer your research questions

- Core facilities to support your research


Your profile:

- Excellent study or research performance.

- You possess high scientific integrity.

- Master’s degree (or equivalent) in immunology, biology, biomedicine, microbiology or similar.

- The project requires animal experimentation (mice), and previous exposure to in vivo work would be advantageous.

- Basic knowledge in immunology, life sciences and molecular biology.

- Ability to work precisely in the laboratory environment.

- Interest to learn germ-free and gnotobiotic animal handling techniques.

- Experience and/or interest to perform data analysis of BCR repertoire and bacterial genomic data using programming languages (mostly R).

- Successful candidates can think independently, are eager to acquire necessary new skills, and are excellent collaborators and communicators.


To apply:

Application documents include a motivation letter, detailed CV (including the names of former mentors and supervisors), publication list (if applicable), relevant transcripts, and recommendation letters and/or contact information of at least two references.

To apply, please send all the required documents in a single .pdf document by e-mail (Subject: PhD application [Name]) to tim.rollenske@uni-bonn.de

Application deadline is the 10th April 2024. Starting date is negotiable.

We are strongly committed to promote equal opportunities independent of gender, ethnicity, age, nationality, religion, disability, etc.. Therefore, applications will be handled in accordance with the State Equality Act.

Additional information:

Institute homepage: www.immei.de

Contact:

Prof. Dr. Tim Rollenske: tim.rollenske@uni-bonn.de

PhD student position at the Department of Anaesthesiology and Intensive Care Medicine

The group of PD Dr. med. Christina Weisheit at the Department of Anaesthesiology and Intensive care Medicine at the University Hospital Bonn is looking for a


PhD student (German salary scale TVL 13 65%).



The DFG approved project „The role of the senescent innate and adaptive immune system in the development of Aortic valve stenosis” is a collaborative project of three working groups in Cologne and Bonn. To analyse the influence of ageing in the immune response in aortic valve stenosis (AS), the department of Anaesthesiology and Intensive Care Medicine of the University Hospital Bonn offers a PhD student position over a period of 3 years. The project will address the role of age on myeloid and lymphoid leukocyte subsets and their role in the pathogenesis of aortic valve stenosis, a progressive inflammatory disease that is, impeding blood ejection from the left ventricle and causing serious cardiovascular complications.

We are seeking a highly motivated and talented candidate with a strong interest in immunology and cardiovascular diseases with the following profile:

- Diploma thesis or Master’s degree in biology, biochemistry, pharmacy, biomedicine or similar.

- Basic knowledge in immunology, life sciences and cellular techniques.

- Excellent skills for team working and communication (oral and writing) in English.

- Experience with in vivo and in vitro experimental models, flow cytometry, and gene sequencing are advantageous.

Doctoral students will participate in a structured program that promotes scientific education and longterm development of medical scientists to pursue their career in the field of translational cardiovascular science.

The University of Bonn is committed to being an equal opportunity employer in our recruitment efforts. Preference will be given to suitably qualified female applicants or handicapped people, all other considerations being equal.

Application:

Please send a Letter of Motivation, C.V. and certificates to PD Dr. med. Christina Weisheit via email to Christina.Weisheit@ukbonn.de using reference number 24-B

Post-Doc position at the Institute of Innate Immunity

Position: Post-Doc position available at the Institute of Innate Immunity

Project: Immune and Molecular Mechanisms Driving Post-Sepsis Immunosuppression


Starting Date: From February 2024

Location: Franklin Lab/Institute of Innate Immunity, Bonn



Are you passionate about unraveling the mysteries of the immune system and its responses to critical conditions? Do you want to make a significant impact on the field of immunology while working alongside a dynamic and dedicated team of researchers? Look no further – an exciting Post-Doc position is available in the Franklin Lab at the Institute of Innate Immunity (III) of the University of Bonn.

About Us: The III is a leading research facility dedicated to advancing our understanding of immunology and its implications for human health. Our team comprises experts from diverse backgrounds, including cell biology, immunology, and proteomics. The III is committed to fostering an environment of collaboration and innovation, and provide an ideal platform for researchers to grow and thrive.

Project Overview: Sepsis, a life-threatening response to infection, can lead to a complex and poorly understood condition called post-sepsis immunosuppression. As a Post-Doctoral Fellow in our lab, you will investigate the intricate immune and molecular mechanisms underlying post-sepsis immunosuppression. This EU-funded research will contribute to identifying potential therapeutic targets that can alleviate the immune dysfunction seen in patients recovering from sepsis.


Qualifications:

- A Ph.D. in Immunology, Cellular and Molecular Biology, or a related field.

- Strong background in immunological techniques, cellular and molecular assays.

- Proven track record of scientific productivity demonstrated by publications.

- Ability to work effectively in a team.


What We Offer:

- State-of-the-art laboratory facilities and resources.

- Mentorship from accomplished researchers in the field.

- Opportunities for career development and networking.

- Vibrant and collaborative research environment.


Application Process: To apply, please submit the following documents to franklin@uni-bonn.de:

CV including a list of publications.
Contact information for at least two professional references.

Join our team and be part of the journey towards understanding and combatting post-sepsis immunosuppression. For more information, please visit www.iii-bonn.de and learn more about our work and the exciting research environment you could be a part of.

Internships

You want to join one of our labs for an internship? We offer funding for
short-term scientific stays for up to four weeks in Bonn / Germany to
PostDocs and PhD students in their final year.

Please take a look at our scientific program for further information on our research areas. If you are a postdoc or PhD student in your final year and interested in a short term fellowship, please contact
immunosensation@uni-bonn.de
, including your CV, a letter of motivation and a statement which research group you would like to join.

We are looking forward to hearing from you.

Join us for an internship