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Open Positions

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PhD positions at the BIGS Immunosciences and Infection

The Cluster of Excellence ImmunoSensation2 is inviting applications for


PhD student positions (m/f/d) (65%)


at the Bonn Graduate School of Immunosciences and Infection.
 

Positions are initially limited to 3 years ImmunoSensation2 is a Cluster of Excellence funded by Germany’s Excellence Strategy at
the University of Bonn. Participating scientists are dedicated to investigating innate
immunity beyond the boundaries of classical immunology. In a joint effort, immunologists,
neuro-biologists, systems biologists and mathematicians of the University of Bonn and the German Center for Neurodegenerative Diseases (DZNE) of the Helmholtz Association aim to connect the status of the immune system, the metabolism and the nervous system to
disease states. ImmunoSensation2 is embedded into the outstanding research environment
of the University of Bonn, the University Hospital and the DZNE. 

Furthermore, ImmunoSensation2 is internationally connected and maintains research partnerships with Australia (Melbourne University), Japan (Osaka University, Kyoto University), Brazil (University of Sao Paulo) and the Netherlands (Radboud University, Nijmegen). Students will have the opportunity to receive additional financial support to participate in a student exchange program (3 to 6 months) with selected principal investigators at these partner
universities.


PhD students will be admitted to the Bonn International Graduate School Immunosciences
and Infection. In this structured PhD program, students gain experience with state-of-the-
art technologies and become part of a vibrant scientific network and an internationally
competitive scientific training program.
The ideal candidate will be highly motivated and team-oriented with a strong interest in
immunology, a first-class academic degree in a life science-related discipline (Master’s
degree or equivalent), a strong background in immune genetics, molecular biomedicine,
molecular biology, biochemistry or cell biology and enthusiasm for working in the highly-
competitive field of innate immunity research. Candidates should have strong communicative skills (fluent spoken and written English) since these are necessary for work in an international research landscape.
 

We offer

  • The salary will be according to the German salary scale TV-L (EG 13)
  • Corporate public transport ticket for the VRS (Verkehrsverbund Rhein-Sieg) or the
    option of an interest-free loan for the purchase of an e-bike
  • There is also a possibility to use the day care center
  • Supplementary benefits in the public sector (pension plan according to VBL)
     

The University of Bonn is committed to diversity and equal opportunity. It is certified as a
family-friendly university. It aims to increase the proportion of women in areas where women are under-represented and to promote their careers in particular. If therefore urges women with relevant qualifications to apply. Applications will be handled in accordance with the Landesgleichstellungsgesetz (State Equality Act). Applications from suitable individuals with a certified serious disability and those of equal status are particularly welcome.

Applicants should send their application in a single pdf file (max. 5 MB) including
motivation letter, CV, scanned academic degrees, list of publications and the contact
details of two references. In your application, please indicate your preferred scientific
projects (max of three). More information on the scientific projects and project leaders can
be found below

More detailed information will be provided during the recruitment process. Successful candidates can begin on 1.1.2025 or upon request.
 

Contact


Please send your application by email using the reference number ST-13098 to the
Cluster Coordination Office until December 12th, 2024 to
 

Dr. rer. nat. Alexandra Krämer
Cluster of Excellence ImmunoSensation2
University Hospital Bonn
Venusberg-Campus 1
53127 Bonn
Phone: +49 (0)228/287-51182
Email: applications_immunosensation@ukbonn.de
 

Please find a list of projects offered below

Cellular Virology - Jun.- Prof. Dr. Stephanie Jung

The research focus of the "Cellular Virology" group is localized in interdisciplinary basic research. It covers the interface between virology, immunology, RNA biology and the new, highly innovative topic of extracellular vesicles. Using both classical and self-developed methods from all these fields, we explore diverse mechanisms which activate and inhibit innate immune signaling. These innate defense processes are evolutionary conserved pathways which restrict viral replication and spread. However, innate immunity itself must also be fine-tuned to cellular requirements to prevent damage to the organism by the antiviral mechanisms themselves. In the context of the advertised position, cellular regulatory mechanisms of innate immunity will be investigated. In particular, we are investigating a previously unknown regulatory mechanism of innate immunity signaling through a naturally occurring metabolite. This mechanism is to be characterized and its effect on viral infections investigated. For more information about our group and our research, please also see our homepage.

University Eye Clinic - Prof. Dr. Volker Busskamp

The convergence of photons into electrochemical signals is the first step in vision. Light perception occurs in the outer segments (OS) of photoreceptor cells in the retina. The structure and function of the OS is highly regulated and dysfunction leads to blindness. In this project, we aim to understand the molecular regulation of OS formation and loss. This is key to inducing the regeneration of these light-sensitive antennae in stem cell-derived human photoreceptors and to restoring light sensitivity in a retinal degenerative disease called retinitis pigmentosa (RP). In RP, rod photoreceptors, which are important for night vision, degenerate due to rod-specific mutations. However, unaffected cone photoreceptors, which mediate high-acuity daytime and color vision, first lose their OS before they also progressively die. To date, the molecular events underlying OS loss in cone photoreceptors during and after rod degeneration are unknown. Here, we propose a systems-level survey at the transcriptomic level to reveal the molecular insults in cones. Subsequently, we will exploit the molecular players as therapeutic tools via gene therapy.

Institute of Human Genetics - Prof. Dr. Kerstin Ludwig

The lab of Kerstin Ludwig is offering 4 projects.

Project I - Investigating the molecular effects of genetic variants contributing to immune diseases

Despite significant advances in identifying genetic variants that contribute to immune traits and diseases, our understanding of the molecular and pathophysiological effects of these variants remains limited. Current computational algorithms used to annotate genetic variants often fall short, particularly when it comes to variants in the non-coding regions of the genome, where tissue- and cell-type-specific regulatory mechanisms are likely at play. Additionally, the rapid advancement of sequencing technologies now enables the generation of individual genome sequences at an unprecedented scale. As these technologies are increasingly applied in clinical settings, the number of genetic variants requiring accurate biological interpretation continues to grow. In this PhD project, you will investigate the functional effects of known genetic risk variants associated with selected immune phenotypes. By (i) systematically mapping base substitutions in the protein-coding regions of clinically relevant immune genes and (ii) analyzing the disease-associated variants in their non-coding regions, you will help to shed light on the genetic underpinnings of both monogenic and multifactorial types of immune diseases as well as infections. Utilizing human biomaterials and in vitro cell models, you will explore the molecular impact of these variants across the entire allelic spectrum, deepening our understanding of immune-related pathologies.

 

Project II - Exploring molecular variability of the immune system and its contribution to common diseases through integrative analyses of multiomics data. 

Recent advances in multiomics technologies (e.g., genomics, transcriptomics, proteomics) have unlocked new opportunities to understand the molecular complexity of the immune system. However, the role of molecular variability in shaping immune traits and its potential associations with common diseases remains largely unexplored. This PhD project will leverage systematic multiomics measurements to investigate how molecular variations in the immune system contribute to health and disease. You will integrate genetic data from genome-wide association studies and genome sequencing with data from additional various biological layers, to develop a comprehensive understanding of immune trait variability. This data-driven computational project will explore regulatory networks and pathways that govern immune responses, ultimately aiming to identify potential biomarkers for disease risk and progression. This research provides a unique opportunity to work at the intersection of immunology, genetics, and molecular biology. Using cutting-edge technologies, you will investigate how immune variability influences disease susceptibility. By collaborating with a multidisciplinary team of experts in bioinformatics, immunology, and systems biology, you will contribute to advancing personalized medicine and improving therapeutic strategies.

 

Project III - Genetic epidemiology of host genetics in infection and disease

As observed during the SARS-CoV-2 pandemic, there is substantial interindividual variability in phenotypes following contact with pathogens, both in the acute phase and over the long term. A portion of this variability can be attributed to differences in the host’s genetic makeup. Moreover, genetic factors underlying infection outcomes are likely to impact the host’s immune system, potentially contributing to other non-infectious diseases. In this project, we will employ genetic epidemiology approaches to identify genetic factors associated with infection outcomes and their relationships with various dimensions of common diseases. By leveraging large biomedical databanks, such as the UKBiobank and Allof Us, we will analyze cohort-level data to uncover genetic contributions to disease progression following infections and the associated health risks mediated by these infections. As a PhD candidate, you will engage in comprehensive data analysis of large datasets, utilizing advanced statistical methods and bioinformatics tools to investigate how host genetic variations influence responses to infections. You will explore the relationships between genetic factors and disease trajectories, contributing to our understanding of susceptibility and resilience in the face of infectious agents. This research presents a unique opportunity to work at the forefront of genetic epidemiology, collaborating with a multidisciplinary team of researchers specializing in genetics, epidemiology, immunology, and infectious diseases. We welcome motivated candidates with a strong background in epidemiology, statistics, or related fields to apply for this position.

 

Project IV

The Ludwig and the Paeschke lab search jointly for two PhD students.

Genomes can form non-canonical (non-B) DNA structures such as guanine quadruplexes (G4). These have been shown to carry biological information beyond the primary sequence and are often located in non-coding regions of the genome. In humans, genetic variants in non-coding regions have been identified as contributors to many multifactorial diseases, and are hypothesized to mediate their effects via modifications to cell-type specific gene expression programs. This collaborative project aims at dissecting the contribution of genetic variation in G4 structures to human trait variation and disease. The project will employ an interdisciplinary approach combining human genetics and molecular biology/biochemistry. Large-scale genetic datasets, including summary statistics from genome-wide association studies (GWAS), will be analyzed to determine if risk variants are enriched within sequences capable of forming G4s. Selected findings will be confirmed at the molecular level, by analyzing downstream effects in cellulo and investigating how, whether individually or as part of multi-variant haplotypes, they affect G4 formation and stability, and how this impacts protein binding. This project is a tandem project which will train two students in complementary research areas, bridging the gap between computational biologists and molecular biochemists. PhD1 will primarily perform the computational work integrating sequences with the potential to form G4s with large-scale systematic genetic and functional data sets. The successful candidate is expected to have a background in life science informatics, bioinformatics, computational biology and/or data science. PhD2 will perform most wet lab experiments and, therefore, should have a background in either molecular biology or cell biology. If you are interested in applying for this project, please indicate your preference (PhD1 or PhD2).

Institute of Clinical Chemistry and Clinical Pharmacology - Prof. Dr. Katrin Paeschke

The Ludwig and the Paeschke lab search jointly for two PhD students.

Genomes can form non-canonical (non-B) DNA structures such as guanine quadruplexes (G4). These have been shown to carry biological information beyond the primary sequence and are often located in non-coding regions of the genome. In humans, genetic variants in non-coding regions have been identified as contributors to many multifactorial diseases, and are hypothesized to mediate their effects via modifications to cell-type specific gene expression programs. This collaborative project aims at dissecting the contribution of genetic variation in G4 structures to human trait variation and disease. The project will employ an interdisciplinary approach combining human genetics and molecular biology/biochemistry. Large-scale genetic datasets, including summary statistics from genome-wide association studies (GWAS), will be analyzed to determine if risk variants are enriched within sequences capable of forming G4s. Selected findings will be confirmed at the molecular level, by analyzing downstream effects in cellulo and investigating how, whether individually or as part of multi-variant haplotypes, they affect G4 formation and stability, and how this impacts protein binding. This project is a tandem project which will train two students in complementary research areas, bridging the gap between computational biologists and molecular biochemists. PhD1 will primarily perform the computational work integrating sequences with the potential to form G4s with large-scale systematic genetic and functional data sets. The successful candidate is expected to have a background in life science informatics, bioinformatics, computational biology and/or data science. PhD2 will perform most wet lab experiments and, therefore, should have a background in either molecular biology or cell biology. If you are interested in applying for this project, please indicate your preference (PhD1 or PhD2).

Department of Orthopedics and Trauma Surgery, University Hospital Bonn - Prof. Dr. Frank Schildberg

Our research focus lies in the field of musculoskeletal immunology. The overall goal is to understand the cellular and molecular mechanisms of musculoskeletal immune responses to develop novel immunology-centered diagnostic and therapeutic options to better predict and treat musculoskeletal pathologies. Specifically, our current studies investigate immune responses in the context of implants and during bone homeostasis.

We are seeking a highly motivated, team-oriented PhD student to conduct research on aspects of osteo- and trauma immunology. The candidate will combine cellular and molecular immunology techniques with in vivo disease models and patient-derived samples to dissect the underlying mechanisms of the communication between immune system and musculoskeletal apparatus. The PhD student will be integrated into the local graduate program BIGS Immunosciences and Infection with outstanding training opportunities in multidisciplinary, interconnected scientific fields and will be supported by additional mentoring and networking opportunities.

Institute of Clinical Chemistry and Clinical Pharmacology - Dr. Nicola Diny

Obesity is an epidemic of global concern, with nearly half of all adults being overweight. Western diet, rich in fat and lipids and poor in aryl hydrocarbon receptor (AHR) ligands, acts on the adipose tissue and affects cellular programming and cellular communication. Eosinophils, through effects on other immune and stromal populations, are key players in adipose tissue physiology and counteract diet-induced metaflammation. Adipose tissue eosinophils have a distinct transcriptional signature when compared to blood eosinophils or those from other tissues, but which transcription factors control adipose tissue eosinophil functions has not been determined. Our previous work demonstrated that eosinophils adapt to the local tissue environment and this adaptation to the intestine is partially controlled by the transcription factor AHR, which regulates a range of eosinophil functions (Diny et al., J Exp Med 2022). This project aims to uncover how dietary regulation of AHR affects adipose tissue eosinophil function and thereby the response to diet-induced obesity.

Institute of Molecular Medicine and Experimental Immunology - Jun.-Prof. Tim Rollenske

B cell Immunology / Mucosal Immunology

Our body sites are populated by a diverse community of microbes, the microbiota. Secretory Immunoglobulin A (SIgA) antibodies on our mucosal surfaces neutralize pathogens and regulate our microbiota. In intestinal immunity, SIgA has a dual role. Despite immune exclusion of pathogens, SIgA facilitates retro-transcytosis of luminal antigens to promote specific IgA induction. However, the impact of constant SIgA-mediated antigen sampling on intestinal B cell immunity and the microbiota remains unknown. To address this, we use a variety of immunological and microbiological methods. This includes but is not limited to germ-free and gnotobiotic model systems, flow cytometry, in vitro binding assays, single B cell sequencing and monoclonal antibody generation. This project aims to decipher SIgA's potential to boost gut immunity to design effective mucosal vaccines and promote gut health

Department of Pediatric Immunology and Rheumatology - Prof. Dr. Kaan Boztug

The lab of Kaan Boztug is offering 2 projects

The Boztug lab at the University Hospital Bonn has a focus on deciphering the molecular origin of inborn errors of immunity and is integrated with the Excellence Cluster ImmunoSensation2. Prof. Kaan Boztug is the newly recruited Clinical Director of the Department of Pediatric Immunology and Rheumatology at the University Hospital of Bonn and PI of an ERC Consolidator grant (iDysChart), integrating basic research into mechanisms of immune dysregulation and clinical translation.

 

Project I - Investigating the molecular basis of autoimmunity and autoinflammation in inborn errors of immunity with aberrant actin dynamics

We invite highly qualified candidates for a PhD position to investigate the molecular mechanisms underlying autoimmunity and autoinflammation in actin-mediated immune defects. In previous work from our lab, we have identified novel immune-mediated actinopathies including HEM1 deficiency or DOCK11 deficiency and deciphered the underlying molecular pathomechanisms (see Salzer E et al., Science Immunol 2020; Block et al., New Engl J Med 2023). 

For this project, we will investigate the cellular and molecular defects arising from a genetic variants affecting actin-regulatory proteins, including novel disease-causing genes. We will decipher the differential effects of immune actinopathies on immune cell development and function, and compare the (epi)genetic profiles characteristic of individual genetic defects. These studies will be complemented by modeling disease mechanisms in suitable cell line and zebrafish model systems. 

 

Project II - Investigating the molecular basis of autoimmunity and autoinflammation in inborn errors of immunity with aberrant actin dynamics

We invite highly qualified candidates for a PhD position to investigate the molecular mechanisms in a novel type of combined immunodeficiency affecting both T- and B-cell development and function. In previous work from our lab, we have successfully deciphered underlying disease mechanisms in other combined immunodeficiencies (see Shahin T et al., Science Immunol 2021; Block et al., New Engl J Med 2023; Köstel Bal et al., Blood 2023). 

For this project, we will investigate the molecular mechanisms underlying aberrant T- and B-cell development including defective stromal cell interaction and compare molecular signaling defects and profiles using single-cell RNA sequencing to known genetic etiology of combined immunodeficiency. We will dissect underlying mechanisms of autoimmunity and autoinflammation such as defective T- and B-cell receptor signaling and excessive inflammasome activation. Based on our findings, we will also consider the potential for therapeutic intervention, supported by both CRISPR- and chemosensitivity screening.

Institute of Clinical Pharmacology and Clinical Chemistry - Jun.-Prof. Swantje Liedmann

In the Liedmann lab our research is focused on generation-spanning immune regulation. How does the environment influence the epigenetic landscape of our germ cells? How are changes to the epigenetic landscape transmitted through generations? And how does that shape the immunity of our children and grandchildren? Questions like these are driving our work. To answer those questions, we utilize human and mouse germ cells, in vivo model systems, and state of the art sequencing technologies.
 

We are looking for candidates with

  • a strong motivation to work in the field of environmental immunology
  • a master’s degree or equivalent
  • a background in immunology, epigenetics, or a related field
  • the ability to work with in vivo models
  • a collaborative attitude and ability to work both independently and in a team
  • very good English skills

PhD candidate (f/m/x) in Systems Medicine

DZNE is a world-leading, internationally oriented center for cutting-edge research into diseases of the nervous system. With its outstanding research personalities and state-of-the-art infrastructure, it offers the best conditions for publications and results at the highest level.

Around 1,200 employees at 10 locations in Germany are working together on new approaches to better understand and effectively combat diseases such as Alzheimer's, Parkinson's and ALS.

That is our goal - maybe soon yours too? Become part of the DZNE and support us in realizing our research strategy!

PhD candidate (f/m/x) in Systems Medicine

Code: 1358/2024/10

The research area Systems Medicine (DZNE Bonn site) is recruiting a PhD candidate (65%) in the field of molecular and translational immunomics.

We are a diverse team working on systems medicine approaches in the context of immunology, chronic inflammation, aging, exposome and neurodegenerative diseases. Our research aims to elucidate the molecular mechanisms by which Per- and polyfluoroalkyl substances (PFASs) exposure impacts the immune system, particularly in the context of aging and non-communicable diseases.

We are currently seeking a highly motivated PhD candidate to join our dynamic team working on cutting-edge research at the intersection of state-of-the-art omics technologies, in-vitro models and computational biology. This position offers a unique opportunity to contribute to understand the clinical impact of the ubiquitous chronic exposure to PFAS worldwide. You will collaborate with an interdisciplinary team of experts spanning various fields, including data and information sciences, immunology, environmental sciences and epidemiological studies.

 

Your role in detail

Your role will involve leveraging high-resolution single-cell multi-omics data and state-of-the-art organoid models to investigate the impact of PFAS on the immune system. You will perform single-cell multi-omics and high-dimensional cytometry experiment, run analyses and established lymphoid organoid systems. This work serves also as a blueprint for the future investigation of the immunotoxicity of various other environmental pollutants.

If you are passionate about addressing impactful questions in systems medicine we encourage you to apply for this PhD candidate position and be part of our transformative research.

For more general information, please also visit the website of Systems Medicine.

 

Your qualifications

  • Master or equivalent in immunology, biomedicine, biotechnology, or comparable topics
  • Strong research background in immunology, cell biology, and genomics or transcriptomics
  • Practical experience in multi-color flow cytometry, molecular and cell biology, and transcriptomics is of advantage
  • Practical knowledge of data analysis and machine learning using R or Python is of advantage
  • Very good English proficiency
  • Enthusiastic and collaborative work attitude
  • Ability to work independently as well as in a team

 

What our employees value

  • Innovation and internationality a forward-looking infrastructure, modern laboratory and office equipment, software tools and the opportunity for international exchange with your colleagues from 65 nations
  • Work-life balance - we reconcile work and private life with flexible working hours, 30 days' holiday (On top free on Christmas Eve and New Year's Eve) and subsidised job/ Germany ticket options
  • Family-conscious corporate culture - because we know that familie is important, we support you with parent-child offices, family services and daycare co-operations
  • Health promotion – through our extensive range of company health programmes, in cooperation with Sozialwerk.Bund
  • Focus on development - training programmes tailored to your individual needs and annual HR-development meetings for concrete prospects and potential development
  • Remuneration and conditions are consistent with those at other research institutes
  • Personalised Onboarding - for a good start to your new professional challenge
  • A feel-good working environment - our Bonn employees enjoy a campus surrounded by greenery, with on-site parking and public transport connections as well our company restaurant
  • The position is initially limited to 3 years

Please submit your application online via the link below as a single pdf file, including your CV (incl. two references) and a brief cover letter (max. 1 page) stating your motivation for and prior experience relating to this offer.

If you have further questions, please contact joachim.schultze@dzne.de. Interviews will take place by video conference, with a possible and subsequent on-site visit to Bonn. The position is available as from January 1st, 2025 and applications will be considered until the position is filled.

Please find the application form here.

PhD candidate (f/m/x) in Systems Medicine

DZNE is a world-leading, internationally oriented center for cutting-edge research into diseases of the nervous system. With its outstanding research personalities and state-of-the-art infrastructure, it offers the best conditions for publications and results at the highest level.

Around 1,200 employees at 10 locations in Germany are working together on new approaches to better understand and effectively combat diseases such as Alzheimer's, Parkinson's and ALS.

That is our goal - maybe soon yours too? Become part of the DZNE and support us in realizing our research strategy!

PhD candidate (f/m/x) in Systems Medicine

Code: 1358/2024/10

The research area Systems Medicine (DZNE Bonn site) is recruiting a PhD candidate (65%) in the field of molecular and translational immunomics.

We are a diverse team working on systems medicine approaches in the context of immunology, chronic inflammation, aging, exposome and neurodegenerative diseases. Our research aims to elucidate the molecular mechanisms by which Per- and polyfluoroalkyl substances (PFASs) exposure impacts the immune system, particularly in the context of aging and non-communicable diseases.

We are currently seeking a highly motivated PhD candidate to join our dynamic team working on cutting-edge research at the intersection of state-of-the-art omics technologies, in-vitro models and computational biology. This position offers a unique opportunity to contribute to understand the clinical impact of the ubiquitous chronic exposure to PFAS worldwide. You will collaborate with an interdisciplinary team of experts spanning various fields, including data and information sciences, immunology, environmental sciences and epidemiological studies.

 

Your role in detail

Your role will involve leveraging high-resolution single-cell multi-omics data and state-of-the-art organoid models to investigate the impact of PFAS on the immune system. You will perform single-cell multi-omics and high-dimensional cytometry experiment, run analyses and established lymphoid organoid systems. This work serves also as a blueprint for the future investigation of the immunotoxicity of various other environmental pollutants.

If you are passionate about addressing impactful questions in systems medicine we encourage you to apply for this PhD candidate position and be part of our transformative research.

For more general information, please also visit the website of Systems Medicine.

 

Your qualifications

  • Master or equivalent in immunology, biomedicine, biotechnology, or comparable topics
  • Strong research background in immunology, cell biology, and genomics or transcriptomics
  • Practical experience in multi-color flow cytometry, molecular and cell biology, and transcriptomics is of advantage
  • Practical knowledge of data analysis and machine learning using R or Python is of advantage
  • Very good English proficiency
  • Enthusiastic and collaborative work attitude
  • Ability to work independently as well as in a team

 

What our employees value

  • Innovation and internationality a forward-looking infrastructure, modern laboratory and office equipment, software tools and the opportunity for international exchange with your colleagues from 65 nations
  • Work-life balance - we reconcile work and private life with flexible working hours, 30 days' holiday (On top free on Christmas Eve and New Year's Eve) and subsidised job/ Germany ticket options
  • Family-conscious corporate culture - because we know that familie is important, we support you with parent-child offices, family services and daycare co-operations
  • Health promotion – through our extensive range of company health programmes, in cooperation with Sozialwerk.Bund
  • Focus on development - training programmes tailored to your individual needs and annual HR-development meetings for concrete prospects and potential development
  • Remuneration and conditions are consistent with those at other research institutes
  • Personalised Onboarding - for a good start to your new professional challenge
  • A feel-good working environment - our Bonn employees enjoy a campus surrounded by greenery, with on-site parking and public transport connections as well our company restaurant
  • The position is initially limited to 3 years

Please submit your application online via the link below as a single pdf file, including your CV (incl. two references) and a brief cover letter (max. 1 page) stating your motivation for and prior experience relating to this offer.

If you have further questions, please contact joachim.schultze@dzne.de. Interviews will take place by video conference, with a possible and subsequent on-site visit to Bonn. The position is available as from January 1st, 2025 and applications will be considered until the position is filled. The application deadline is November 30th.

Please find the application form here

PhD Student position in infection biology (m/f/d)

We combine excellence in research, teaching and patient care. The University Hospital Bonn is a maximum care hospital with more than 1,300 beds. With around 38 clinics and 31 institutes as well as more than 8,000 employees (over 5,000 full-time staff), the UKB is one of the largest employers in Bonn. Every year, the UKB treats around 50,000 inpatients and around 35,000 emergencies, as well as providing over 350,000 outpatient treatments.
 

The research group “Cellular Virology” at the Faculty of Medicine of the Rheinische Friedrich Wilhelms-University Bonn invites applications for a PhD Student position in infection biology (m/f/d) (part-time position 65 %)
 

The position is available for a period of 3 years due the project, with the possibility of extension.
We are seeking a highly motivated candidate to fill a Ph.D. student position in infection biology in the research group “Cellular Virology” under the direction of Jun.- Prof. Dr. Stephanie Jung.
The research focus of the "Cellular Virology" group is localized in interdisciplinary basic research. It covers the interface between virology, immunology, RNA biology and the new, highly innovative topic of extracellular vesicles. Using both classical and self-developed methods from all these fields, we explore diverse mechanisms which activate and inhibit innate immune signaling. These innate defense processes are evolutionary conserved pathways which restrict viral replication and spread. However, innate immunity itself must also be fine-tuned to cellular requirements to prevent damage to the organism by the antiviral mechanisms themselves. In the context of the advertised position, cellular regulatory mechanisms of innate immunity will be investigated.
For more information about our group and our research, please also see our homepage.

 
The group is embedded into the Institute of Cardiovascular Immunology and the Cluster of Excellence ImmunoSensation2 in Bonn and offers a great environment for young researchers. The PhD position will be integrated into the local graduate program BIGS Immunosciences and Infection with outstanding training opportunities in multidisciplinary, interconnected scientific fields and supported by the additional mentoring and networking opportunities. PhD students will benefit from state-of-the-art technologies, high-end laboratories, a vibrant scientific network and an internationally competitive scientific training program.


Requirements

  • Master or diploma in life science (biology, biomedicine, molecular medicine or comparable studies)
  • profound knowledge in basic molecular biological methods and cell culture
  • experience in working with RNA and / or infection biology methods would be ideal
  • ability to work independently and in a team
  • excellent management and communication skills
  • strong ability to draw logical conclusions
  • high intrinsic motivation and enthusiasm as well as a deep interest in Biomedicine and infection biology
  • English or German skills at C1 level or higher
  • experienced handling of MS Office applications

 

We offer

  • A salary according to the German salary scale TV-L E13
  • Corporate customer ticket (subsidized public transport) is available
  • Possibility to use the day care center
  • Supplementary benefits in the public sector (pension plan according to VBL)
  • A diverse and demanding job with one of the largest employers in the region
  • An innovative research area with an extremely collegial approach and many possibilities for novel discoveries and development of your own ideas
  • A good methodical education and excellent supervision in a small friendly group
  • Best possible support in your professional development
  • Possibility for further education in university and non-university courses
     

The University of Bonn is committed to diversity and equal opportunity. It is certified as a family-friendly university. It aims to increase the proportion of women in areas where women are under-represented and to promote their careers in particular. It therefore urges women with relevant qualifications to apply. Applications will be handled in accordance with the Landesgleichstellungsgesetz (State Equality Act). Applications from suitable individuals with a certified serious disability and those of equal status are particularly welcome.
If you are interested in the position, please send your application as a single pdf-file including a cover letter, curriculum vitae, university-entrance certificate, university certificates and the contact details of two references. Applications should be send by email until 8th December under indication of reference number ST-11078 to:

Jun.-Prof. Dr. Stephanie Jung
“Cellular Virology”
University Hospital Bonn
Venusberg-Campus 1
53127 Bonn
Email: sjung@uni-bonn.de

PhD position in Cellular Immunology (m/f/x)

The Life & Medical Sciences (LIMES) Institute is offering a

PhD position in Cellular Immunology

at the Department of Immune- and Tumor Biology starting latest in February 2025. The position is placed in the laboratory of Prof. Eva Kiermaier at the LIMES Institute in Bonn. The Institute is part of the Faculty of Mathematical and Natural Sciences at the University of Bonn. We are seeking for a highly motivated PhD candidate to work at the interface of cell biology and immunology. The project focuses on the regulation of centrosomes during immune processes. We mainly concentrate on centrosome structure, function and regulation in human and mouse dendritic cells – the most potent antigen presenting cells of the innate immune system. The lab combines cell based in vitro assays with studies in living animals (mouse) to provide a complete picture of the molecular basis of centrosome-mediated immunity.

The applicant should hold a master degree in cell biology, biochemistry or immunology. We particularly look for applicants with a collaborative attitude towards research and who can combine high personal ambition and work ethics with eagerness to contribute to other projects.

Salary is paid according to German TV-L (E13; 65%).

The University of Bonn is an equal opportunities employer.

Complete applications in English should include a CV, a brief statement of research experiences and interests and addresses of two referees. Please submit your application as a single pdf file to Eva Kiermaier (eva.kiermaier@uni-bonn.de) before October 15th.

Postdoctoral Scientist Immune diversity and Brain Health (f/m/x)

The German Center for Neurodegenerative Diseases (DZNE) is a world-leading internationally oriented research center, committed to discovering new approaches to prevent and treat neurodegenerative diseases. To this end, researchers at ten DZNE sites across Germany pursue a translational and interdisciplinary strategy comprising five interconnected areas: fundamental research, clinical research, health care research, population health science, and systems medicine. www.dzne.de

Postdoctoral Scientist Immune diversity and Brain Health (f/m/x)


Code: 1306/2024/4

We are looking for an ambitious researcher with experience with immunology and a keen interest in large scale data analyses to join our Population Health Sciences group at the German Center for Neurodegenerative Diseases (DZNE) in Bonn.

We investigate causes and biomarkers of neurodegenerative and other ageing related disorders, with the ultimate goal of enabling personalized disease prevention. Our research is primarily based on the Rhineland Study, a prospective cohort study that emphasizes deep phenotyping. The study currently includes more than 11.000 participants at baseline, follow-up data is already available from nearly 5.000 participants, and further data collection is ongoing. Available clinical data include detailed structural and functional brain imaging, cognitive and neurological assessments, cardiovascular and anthropometric assessments, sensory systems tests, and medical history and medication use data. Available multi-omics data, both from baseline and follow-up, include (epi) genomic, transcriptomic, metabolomic, lipidomic, proteomic and microbiome data. A special research focus is on the role of the immune system in health and disease. To this end, we also included FACS analyses, immune stimulation assays and extensive cytokine profiling into our core protocols. We collaborate with multiple partners at Bonn University in the Cluster of Excellence “Immunosensation” and the Collaborative Research Center “Metaflammation”.

Your tasks

In addition to contributing to ongoing projects, you will lead and develop your own research projects aligned with our group's research interests. This includes conducting and overseeing experiments in the laboratory, analyzing data, and preparing publications for peer-reviewed journals. Furthermore, you will actively participate in national and international conferences and engage with the scientific community. You will have the opportunity to supervise PhD and master's students and – if desired – to be involved in teaching.

Requirements

The ideal candidate will have a strong track record of excellence in research, outstanding analytical and communication skills, and a demonstrated ability to work collaboratively in a dynamic team-oriented environment. If you are passionate about making meaningful contributions to the field of non-communicable diseases and immunology, we encourage you to apply.

We offer

The position is initially limited to three years with the possibility of extension. We are looking for motivated individuals to help us address pressing health issues related to aging. As a member of our highly interdisciplinary and international team, you will have access to excellent scientific infrastructure with state-of-the-art research and computational facilities. You will have excellent publication opportunities and great potential for the further development of your own research profile. We actively encourage and support personal development, and offer employment, payment, and social benefits that are in line with other leading research institutes.

How to apply

Interested applicants should submit, as one single PDF file, a CV, transcripts, 3 references, and a cover letter describing your motivation to apply for this position, including research interest and experience, through the following link below

Review of applications will begin immediately and continue until the position is filled.

For inquiries about the position, please contact Prof Dr Dr Monique Breteler at population-research@dzne.de

PhD position – Metabolic regulation of tissue-resident immune cells during cancer development (m/f/x)

The Tumor Immunometabolism research group led by Jun. Prof. Laura Surace at the Institute of Clinical Chemistry and Clinical Pharmacology (University Hospital Bonn Campus), Faculty of Medicine Rheinische Friedrich Wilhelms-University Bon invites applications for

PhD position – Metabolic regulation of tissue-resident immune
cells during cancer development

 

We are seeking highly motivated candidates with a strong interest in immunology. Our lab is interested in better understanding the role of tissue-resident immune cells in tumor development and response to therapies. We aim to achieve this by defining their metabolic requirements, phenotype and function and by assessing their interplay with the other components of the tumor microenvironment. We specifically focus on innate lymphoid cells (ILC) and T cells (Karagiannis F*, Peukert K*, Surace L*, et al. Nature 2022; Surace et al.
Nature Immunology 2021; Surace et al. Blood Advances 2021). For more information please refer to the website.


The project will investigate how changes in host metabolism and diet-derived small molecules in health and disease (e.g. obesity) shape the composition and metabolic features of the tumor microenvironment and the antitumor immunity during tumor onset and progression. Ultimately the goal is to identify novel therapeutic strategies, including dietary intervention, that would be applicable in the treatment of cancer.


Requirements

  •  Master’s degree in life science (biology, biomedicinebiomedicine, molecular medicine or comparable studies).
  • Candidates with experience in immunology, molecular or cell biology and biochemistry are specifically encouraged to apply
  • Experience in laboratory techniques and the use of experimental mouse models
  • Ability to work independently and in a team
  • English skills

The candidate will work with mouse models and human samples applying classical immunological methods alongside cutting-edge technologies, including imaging mass spectrometry, multiplex tissue imaging, metabolomics and extracellular flux analysis. The selected candidate will have access to scientific and soft skill training through courses provided by the University of Bonn and external institutions.

We offer

  • A contract for an initial period of three years, with the possibility of extension.
  • The salary according to the German salary scale TV-L
  • A “Jobticket” (subsidized public transport)
  • The possibility to use the day care center
  • Supplementary benefits in the public sector (pension plan according to VBL)
  • Attractive conditions and benefits, an interdisciplinary research institution that fosters innovation and collaboration and are committed to mentoring and the career
    development of the next generation of scientists.
  • The opportunity to work as part of a young and motivated team within a thriving research environment


The University of Bonn is committed to diversity and equal opportunity. It is certified as a familyfriendly university. It aims to increase the proportion of women in areas where women are under-represented and to promote their careers in particular. It therefore urges women with relevant qualifications to apply. Applications will be handled in accordance with the Landesgleichstellungsgesetz (State Equality Act). Applications from suitable individuals with a certified serious disability and those of equal status are particularly welcome.
 

Applications should include

  • a CV
  • a cover letter outlining why you are applying
  • certificates
  • the contact information of two referees
     

These information should be send by e-mail by the 31st of November 2024 to:

Jun. Prof. Laura Surace
W1-tenure track
Institute of Clinical Chemistry and Clinical Pharmacology
University Hospital Bonn
University of Bonn
Venusberg-Campus 1
53127 Bonn, Germany
E-Mail: mailto:lsurace@uni-bonn.de

Internships

You want to join one of our labs for an internship? We offer funding for
short-term scientific stays for up to four weeks in Bonn / Germany to 
PostDocs and PhD students in their final year.

Please take a look at our scientific program for further information on our research areas. If you are a postdoc or PhD student in your final year and interested in a short term fellowship, please contact the principal investigator of the working group you are interested in directly. Your application should including your CV and a letter of motivation. For further questions you can contact immunosensation@uni-bonn.de.

 

We are looking forward to hearing from you.
 

Join us for an internship