Open Positions

The University Hospital Bonn (UKB) is a maximum care hospital with more than 1,300 beds. Our more than 9,000 employees take on tasks in research, teaching and patient care as well as in public health at the highest level. In the science ranking (LOMV) and in the economic result, the UKB is number 1 of the university hospitals in NRW and in 2021 had the third highest case mix index of the university hospitals in Germany.

The group of Prof. Dr. med. Kaan Boztug at the Clinic of Pediatric Immunology and Rheumatology (Centre of Pediatric, University Hospital Bonn) offers a

PhD position in immunobiology of selected inborn errors of immunity (m/f/d)

(part-time position 65% limited due the promotion for three years)

Prof. Kaan Boztug is the newly recruited Clinical Director of the Department of Pediatric Immunology and Rheumatology at the University Hospital of Bonn and Principal Investigator of an ERC Consolidator grant (iDysChart), integrating basic research into mechanism of the immune dysregulation and clinical translation. The Boztug lab is focusing on the discovery of inborn errors of immunity (IEI) and the dissection of their underlying molecular pathomechanisms. The ultimate aim of our research is to enhance the molecular understanding of these disorders to enable the use of tailored treatment approaches.

We invite highly qualified candidates for a PhD position to investigate the molecular mechanisms underlying autoimmunity and autoinflammation in actin-mediated immune defects. In previous work from our lab, we have identified novel immune-mediated actinopathies including HEM1 deficiency or DOCK11 deficiency and investigated the molecular underpinnings of the respective defects (Salzer E et al., Science Immunol 2020; Block et al., New Engl J Med 2023).

For this project, we will investigate the cellular and molecular defects arising from genetic variants affecting actin-regulatory proteins, including novel disease-causing genes. We will decipher the differential effects of actinopathies on immune cell development and function, and compare the (epi)genetic profiles characteristic of individual genetic defects. These studies will be complemented by modeling disease mechanisms in suitable cell lines and zebrafish model systems.

What we offer:

• A dynamic, international and interdisciplinary working environment with a strong focus on immunology and genetics
• Close collaboration with leading scientists in the field of pediatric immunology and rheumatology
• Member of the Excellence Cluster of ImmunoSensation2 with the possibility to participate in national and international conferences
• Excellent core facilities to support your research across the campus
• Salary according to the German salary scale TV-L 13 (65%) initially limited to 3 years
• Responsible and versatile: a job with a lot of creative freedom in a collegial team
• Flexible for families: flexible working time models, the option of a place in the company day-care center and offers for those returning from parental leave
• Provision for later: company pension scheme
• Clever to work: Possibility of an interest-free loan to buy an e-bike
• Tailor-made education: Subsidized further education and training
• Systematic start: Structured induction
• Healthy at work: Numerous health promotion offers, free membership in UKBfit
• Employer benefits: preferential offers for employees (corporate benefits)
•  

The University of Bonn is a German University of Excellence since 2019. The Medical Faculty is a hub for internationally recognised immunological institutes and part of the Excellence Cluster of Immunosensation2 in Germany (www.immunosensation.com).

We are committed to diversity and equal opportunities. Our goal is to increase the proportion of women in areas where women are underrepresented and to particularly promote their careers. We therefore urge relevantly qualified women to apply. Applications are treated in accordance with the State Equal Opportunities Act. Applications from suitable people with proven severe disabilities and those of equal status are particularly welcome.

Requirements:

• Master’s degree in life sciences (biology, biomedicine, immunology or comparable studies)
• Scientific background in immunology, molecular and cell biology, bioinformatics skills are welcome
• Practical experience in molecular and cell biology, Western blot and FACS
• Ability to work independently and in a team
• Good English skills in speaking and writing
• Enthusiastic and collaborative work attitude

Applicants should send their application in a single pdf file (max. 5 MB) including a motivation letter, CV and scanned academic degrees. Please send your application stating the job advertisement number ST-23005 until 11.06.2025 to

Herr Prof. Dr. med. Kaan Boztug

Zentrum für Kinder- und Jugendmedizin

Klinik für Pädiatrische Immunologie und Rheumatologie

Universitätsklinikum Bonn

Venusberg-Campus-1

53127 Bonn

E-Mail: Recruiting.Boztug@ukbonn.de

The University Hospital Bonn (UKB) is a maximum care hospital with more than 1,300 beds. Our more than 9,000 employees take on tasks in research, teaching and patient care as well as in public health at the highest level. In the science ranking (LOMV) and in the economic result, the UKB is number 1 of the university hospitals in NRW and in 2021 had the third highest case mix index of the university hospitals in Germany.

The group of Prof. Dr. med. Kaan Boztug at the Clinic of Pediatric Immunology and Rheumatology (Centre of Pediatric, University Hospital Bonn) offers 

Postdoc position: mechanisms of autoimmunity and autoinflammation in inborn errors of immunity (m/f/d) 

(full-time position 100 % limited for four years)

Prof. Kaan Boztug is the newly recruited Clinical Director of the Department of Pediatric Immunology and Rheumatology at the University Hospital of Bonn and Principal Investigator of an ERC Consolidator grant (iDysChart), integrating basic research into mechanisms of the immune dysregulation and clinical translation. The Boztug lab is focusing on the discovery of inborn errors of immunity (IEI) and the dissection of their underlying molecular pathomechanisms. The ultimate aim of our research is to enhance the molecular understanding of these disorders to enable the use of tailored treatment approaches.

We invite highly experienced and motivated candidates for a Postdoctoral fellow position to investigate the molecular mechanisms underlying autoimmunity and autoinflammation. In earlier work from our lab, we have identified previously unknown inborn errors of immunity to decipher key regulators of human immune homeostasis (Ardy RC et al., Gastroenterology 2018; Wang L et al., Nat Genet 2021; Salzer E et al., Science Immunol 2020; Block et al., New Engl J Med 2023).

For this project, we have already identified novel disease-causing monogenic variants in autoimmunity and autoinflammatory diseases such as childhood-onset inflammatory bowel disease (IBD) and systemic lupus erythematosus (SLE). This project will integrate biochemical, immunological, and imaging techniques, along with co-culture of patient-derived organoids and model organisms combined with various –omics approaches, to understand the molecular mechanisms underlying these conditions, and to derive potential targeted treatment options (precision medicine).

What we offer:

• A dynamic, international and interdisciplinary working environment with a strong focus on immunology
• Close collaboration with leading scientists in the field of pediatric immunology and rare immune disorders
• Opportunities for professional development and career advancement within the research community
• Member of the Excellence Cluster of ImmunoSensation2 with an interdisciplinary network of excellent scientists
• Excellent core facilities to support your research across the campus
• Salary according to the German salary scale TV-L 13 (100% including additional benefits) initially limited to 4 years with the prospect of extension
• Responsible and versatile: a job with a lot of creative freedom in a collegial team
• Flexible for families: flexible working time models, the option of a place in the company day-care center and offers for those returning from parental leave
• Provision for later: company pension scheme
• Clever to work: Possibility of an interest-free loan to buy an e-bike
• Tailor-made education: Subsidized further education and training
• Systematic start: Structured induction
• Healthy at work: Numerous health promotion offers, free membership in UKBfit
• Employer benefits: preferential offers for employees (corporate benefits)

The University of Bonn is committed to diversity and equal opportunity. It is certified as a family-friendly university. It aims to increase the proportion of women in areas where women are under-represented and to promote their scientific careers in particular. If therefor urges women with relevant qualitfications to apply. Applications will be handled in accordance with the Landesgleichstellungsgesetz (State Equality Act). Applications from suitable individuals with a certified serious disability and those of equal status are particularly welcome. The Medical Faculty is a hub for internationally recognised immunological institutes and part of the Excellence Cluster of Immunosensation2 in Germany (www.immunosensation.com).

Requirements:

• PhD degree in life sciences (biology, biomedicine, immunology or comparable studies)
• Scientific background in immunology, molecular and cell biology, and bioinformatics
• Practical experience in immunology, molecular and cell biology, hematology and genetics, and imaging techniques
• Excellent organizational and communication skills, with the ability to handle multiple tasks simultaneously
• Strong English skills with excellent writing and presentation abilities
• Enthusiastic and collaborative work attitude

Applicants should send their application in a single pdf file (max. 5 MB) including a motivation letter, CV, scanned academic degrees, list of publications and the contact details of two references stating the job advertisement number ST-23007 until 11.06.2025 to

Herr Prof. Dr. med. Kaan Boztug

Zentrum für Kinder- und Jugendmedizin

Abteilung für Pädiatrische Immunologie und Rheumatologie

Universitätsklinikum Bonn

Venusberg-Campus-1

53127 Bonn

E-Mail: Recruiting.Boztug@ukbonn.de

DZNE is a world-leading, internationally oriented center for cutting-edge research into diseases of the nervous system. With its outstanding research personalities and state-of-theart infrastructure, it offers the best conditions for publications and results at the highest level. Around 1,200 employees at 10 locations in Germany are working together on new approaches to better understand and effectively combat diseases such as Alzheimer's, Parkinson's and ALS. That is our goal - maybe soon yours too? Become part of the DZNE and support us in realizing our research strategy!

1 PhD student (f/m/x) in the field of Neuroimmunology

We are seeking an enthusiastic and motivated PhD student to conduct research at the interface of immunology and neuroscience. The student will be a member of the ‘Translational Neuroimmunology’ research group, led by Dr. Róisín McManus, which is based at the DZNE in Bonn and is also associated with the Institute of Innate Immunity at the University Hospital Bonn, the ImmunoSensation2 Cluster of Excellence and the Collaborative Research Centre “Metaflammation” (SFB 1454). Our research focuses on understanding how microglia-mediated neuroinflammation contributes to the progression of Alzheimer’s disease. Specifically, we examine how immune signaling and metabolic changes combine to modulate microglial function, affecting disease outcome.

Your role in detail

Our recent work has uncovered that consumption of a western diet can drive lipid changes that activate microglia, causing neuroinflammation. Using a series of animal models of dementia, murine cell culture models and samples from patients, the goal of your PhD will be to unravel the innate immune pathways mediating these neuroinflammatory changes, and thus contribute to Alzheimer’s disease. Specifically, this position is part of an international interdisciplinary collaboration and will involve cell culture work using murine and human cells, immune activation assays and state of the art lab techniques (metabolic assays, flow cytometry, fluorescence imaging, RNA sequencing and biochemical techniques e.g. western blot, quantification assays). Combining diet treatments, pharmacological inhibition and genetic depletion approaches, the successful applicant will assess the full impact of western diet on microglial activity both in vivo, ex vivo and in vitro.

Your qualifications

• A MSc degree in one of the following fields: Immunology, Neuroscience, Biology or similar

• Previous experience in experimental animal work and immunology, neuroscience or cell metabolism research would be very beneficial

• FELASA accreditation is a strong plus

• Hands on experience in cell culture (e.g. murine microglia or macrophages, or cells generated from human iPSCs) and biochemistry techniques (protein assays, western blot, PCR). Familiarity in immunohistochemistry or flow cytometry is a plus

• Fluency in English for communicating, writing, and presentation of scientific data

• Strong enthusiasm and motivation for interdisciplinary research, with an interest to explore and innovate with new techniques

• Ability to work independently and within a diverse and interdisciplinary team of international scientists

Interested applicants should submit a cover letter, CV, two reference letters and transcripts in one single PDF file. The cover letter should describe your motivation to apply for this position and detail how your research interests and experience align with the research that is conducted in our group. Please highlight any relevant projects or publications. Only applications submitted via our portals will be accepted. Please refrain from sending your application by e-mail. Review of applications will begin immediately and continue until the position is filled. 

For questions related to the position, please contact Dr. Róisín McManus at roisin.mcmanus@dzne.de

We look forward to receiving your application via this link.

What our employees value

• Innovation and internationality a forward-looking infrastructure, modern laboratory and office equipment, software tools and the opportunity for international exchange with your colleagues from 65 nations

• Work-life balance - we reconcile work and private life with flexible working hours, mobile working, 30 days' holiday (On top free on Christmas Eve and New Year's Eve) and subsidised job/ Germany ticket options

• Family-conscious corporate culture - because we know that family is important, we support you with parent-child offices, family services and daycare co-operations

• Health promotion – through our extensive range of company health programmes, in cooperation with Sozialwerk.Bund

• Focus on development - training programmes tailored to your individual needs and annual HR-development meetings for concrete prospects and potential development

• Remuneration and conditions according to TVöD-Bund - including annual special payment, capital-forming benefits and VBL supplementary pension scheme

• Job with prospects - the position, which is initially limited to two years, offers the opportunity to become a permanent position

• Personalised Onboarding - for a good start to your new professional challenge

• A feel-good working environment - our Bonn employees enjoy a campus surrounded by greenery, with on-site parking and public transport connections as well our company restaurant

Im UKB werden pro Jahr etwa 500.000 Patient*innen betreut, es sind ca. 9.000 Mitarbeiter*innen beschäftigt und die Bilanzsumme beträgt 1,6 Mrd. Euro. Neben den über 3.300 Medizin- und Zahnmedizin-Studierenden werden pro Jahr weitere 585 Personen in zahlreichen Gesundheitsberufen ausgebildet. Das UKB steht im Wissenschafts-Ranking sowie in der Focus-Klinikliste auf Platz 1 unter den Universitätsklinika (UK) in NRW und weist den dritthöchsten Case Mix Index (Fallschweregrad) in Deutschland auf. 

In der Klinik und Poliklinik für Pädiatrische Immunologie und Rheumatologie des Universitätsklinikums Bonn ist zum nächstmöglichen Zeitpunkt folgende Stelle in Vollzeit (38,5 Std./Woche) zu besetzen:

Technische*r Angestellte*r (MTLA, BTA, CTA, Biologielaborant*in) (m/w/d)

Die Stelle ist aufgrund der Neugründung der Klinik für zwei Jahre befristet (30.04.2027) zu besetzten (mit der Option auf Verlängerung). 

Die Stelle ist an der Schnittstelle zwischen der immunologischen Forschung (Exzellenzcluster ImmunoSensation) und dem Zentrallabor des Universitätsklinikums Bonn angesiedelt und widmet sich der speziellen Immundiagnostik einschließlich seltener Erkrankungen oder Erkrankungen ungeklärten Ursprungs. Die Einheit Spezielle Immundiagnostik unter der gemeinsamen wissenschaftlichen Leitung von Prof. Kaan Boztug und Prof. Gunther Hartmann umfasst allgemeine und spezielle immundiagnostische Verfahren zur Beantwortung von klinisch-immunologischen Fragestellungen. Dazu gehören die Isolation primärer Immunzellen, zellbiologische und molekularbiologische Techniken, sowie Einzelzell- und Omics-Technologien.

Ihr Profil:
 

• Abgeschlossene Ausbildung zum*zur BTA, MTLA oder CTA (m/w/d) oder eines verwandten naturwissenschaftlichen Studienabschlusses
• Erfahrung in Bereichen der Immundiagnostik oder Routinediagnostik (Durchflusszytometrie, Zellkultur, zellbiologische und molekularbiologische Verfahren, RNA/DNA Isolation, qPCR, Omics-Technologien)
• Kenntnisse moderner Sequenziertechniken ist ein Plus (scRNAseq, bulk RNAseq, ATAC, ChIP)
• Übernahme von organisatorischen Aufgaben im Labor
• Teamfähigkeit und Serviceorientierung sowie selbständiges Arbeiten
• Solide Englischkenntnisse erforderlich, Umgangssprache im Labor ist Englisch

Wir bieten: 
 

• Ein internationales, interdisziplinäres Forschungsteam, das immunologische Forschung mit spezieller Immundiagnostik verbindet
• Verantwortungsvoll und vielseitig: ein Arbeitsplatz mit großem Gestaltungsspielraum in einem kollegialen Team
• Bezahlung nach TV-L: Tarifliche Vergütung inkl. Jahressonderzahlung, betriebliche Altersvorsorge  
• Flexibel für Familien: flexible Arbeitszeitmodelle, Gleitzeit, Möglichkeit auf einen Platz in der Betriebskindertagesstätte und Angebote für Elternzeitrückkehrer
• Clever zur Arbeit: Gute Anbindung an das SWB-Netz, Möglichkeit eines zinslosen Darlehens zur Anschaffung eines E-Bikes
• Geförderte Fort- und Weiterbildung: Individuelle Entwicklungschancen durch Kurse, E-Learning und Coachings
• Start mit System: Strukturiertes Onboarding
• Gesund am Arbeitsplatz: Zahlreiche Angebote der Gesundheitsförderung, kostenlose Mitgliedschaft im UKB-Fitnessstudio
• Arbeitgeberleistungen: Vergünstigte Angebote für Mitarbeiter*innen (Corporate Benefits)

Wir setzen uns für Diversität und Chancengleichheit ein. Unser Ziel ist es, den Anteil von Frauen in Bereichen, in denen Frauen unterrepräsentiert sind, zu erhöhen und deren Karrieren besonders zu fördern. Wir fordern deshalb einschlägig qualifizierte Frauen nachdrücklich zur Bewerbung auf. Bewerbungen werden in Übereinstimmung mit dem Landesgleichstellungsgesetz behandelt. Die Bewerbung geeigneter Menschen mit nachgewiesener Schwerbehinderung und diesen gleichgestellten Personen ist besonders willkommen.

Sie erfüllen die Anforderungen und suchen eine abwechslungsreiche und herausfordernde Tätigkeit? Zögern Sie nicht und senden Sie Ihre Bewerbung als ein pdf per E-Mail (bis 5 MB Größe) bis zum 31.05.2025 unter Angabe der Stellenanzeigen-Nr. ST-19041 an:

Prof. Dr. Kaan Boztug, Klinik für Pädiatrische Immunologie und Rheumatologie

Prof. Dr. Gunther Hartmann, Institut für Klin. Chemie und Klin. Pharmakologie

Universitätsklinikum Bonn, Venusberg-Campus 1, 53127 Bonn

Tel.: +49 (0)228/ 287-16081 

E-Mail: natalia.dimitrova@ukbonn.de

www.ukbonn.de

www.ukbonn.de/ikckp

www.immunosensation.de

Im UKB werden pro Jahr etwa 500.000 Patient*innen betreut, es sind ca. 9.000 Mitarbeiter*innen beschäftigt und die Bilanzsumme beträgt 1,6 Mrd. Euro. Neben den über 3.300 Medizin- und Zahnmedizin-Studierenden werden pro Jahr weitere 585 Personen in zahlreichen Gesundheitsberufen ausgebildet. Das UKB steht im Wissenschafts-Ranking sowie in der Focus-Klinikliste auf Platz 1 unter der Universitätsklinika (UK) in NRW und weist den dritthöchsten Case Mix Index (Fallschweregrad) in Deutschland auf.

In der Klinik für Pädiatrische Immunologie und Rheumatologie des Zentrums für Kinder- und Jugendmedizin ist zum nächstmöglichen Zeitpunkt folgende Stelle in Vollzeit (42 Std./Woche) zu besetzten: 

Oberärztin*arzt (m/w/d) für die Klinik für Pädiatrische Immunologie und Rheumatologie

Die Stelle ist unbefristet zu besetzen. In unserer Abteilung behandeln wir Kinder und Jugendliche mit dem gesamten Spektrum immunologischer und rheumatologischer Krankheitsbilder im Kindesalter. Dies umfasst insbesondere ein breites Spektrum an angeborenen Immundefekten und rheumatologischen und Autoinflammationserkrankungen im ambulanten sowie stationären Bereich. Die Klinik ist auch involviert in der konsiliarischen Abklärung und Betreuung bei Verdacht auf Immundefizienz in den anderen Abteilungen am Zentrum für Kinder- und Jugendmedizin. Eine Beteiligung an verschiedenen klinisch-translationalen wissenschaftlichen Projekten ist möglich und ausdrücklich erwünscht.

Ihre Aufgaben:

• Verantwortungsvolle, interessante und abwechslungsreiche klinische Tätigkeit in der ambulanten und stationären Betreuung von Patient*innen mit angeborenen Immundefekten und rheumatologischen Erkrankungen

• Begleiten und Führen der medizinischen Versorgung von Patient*innen

• Lehrtätigkeit am Patientenbett, in Seminaren und Vorlesungen

• Anleiten des Ärzteteams einschließlich Rotationsassistent*innen der Pädiatrie

• Beteiligung an konsiliarischen Abklärungen und interdisziplinären Board-Besprechungen von Patient*innen mit V.a. Immundefekt oder rheumatologischen Erkrankungen

• Kommunikation mit zuweisenden Kliniken und niedergelassenen Kolleg*innen

Ihr Profil:

• Fachärztliche Qualifikation in der Kinderheilkunde

• Abgeschlossene Promotion

• Hohe klinische Kompetenz und Erfahrung

• Einschlägige Vorerfahrung in der Diagnostik und Therapie kindlichrheumatologischer Krankheiten und angeborener Immundefekterkrankungen, idealerweise zusätzliche Erfahrung im Bereich Stammzelltransplantation

• Wissenschaftliches Interesse

• Engagierter und verständnisvoller Umgang mit unseren „kleinen" Patientinnen und Patienten

• Organisationstalent und Kommunikation mit zuweisenden Kliniken und niedergelassenen Kolleg*innen

• Freude an der Mitarbeit in einem multiprofessionellen Team

Wir bieten:

• Verantwortungsvoll und vielseitig: ein Arbeitsplatz mit großem Gestaltungsspielraum in einem kollegialen Team

• Bezahlung nach TV-Ä3: Tarifliche Vergütung, betriebliche Altersvorsorge

• Flexibel für Familien: flexible Arbeitszeitmodelle, Gleitzeit und Homeoffice Möglichkeit (in einigen Bereichen), Möglichkeit auf einen Platz in der Betriebskindertagesstätte und Angebote für Elternzeitrückkehrer

• Clever zur Arbeit: Gute Anbindung an das SWB-Netz, Möglichkeit eines zinslosen Darlehens zur Anschaffung eines E-Bikes

• Geförderte Fort- und Weiterbildung: Individuelle Entwicklungschancen durch Kurse, ELearning und Coachings

• Start mit System: Strukturiertes Onboarding

• Gesund am Arbeitsplatz: Zahlreiche Angebote der Gesundheitsförderung, kostenlose Mitgliedschaft im UKB-Fitnessstudio

• Arbeitgeberleistungen: Vergünstigte Angebote für Mitarbeiter*innen (Corporate Benefits)

Wir setzen uns für Diversität und Chancengleichheit ein. Unser Ziel ist es, den Anteil von Frauen in Bereichen, in denen Frauen unterrepräsentiert sind, zu erhöhen und deren Karrieren besonders zu fördern. Wir fordern deshalb einschlägig qualifizierte Frauen nachdrücklich zur Bewerbung auf. Bewerbungen werden in Übereinstimmung mit dem Landesgleichstellungsgesetz behandelt. Die Bewerbung geeigneter Menschen mit nachgewiesener Schwerbehinderung und diesen gleichgestellten Personen ist besonders willkommen.

Kontakt:

Sie erfüllen unsere Anforderungen und suchen eine abwechslungsreiche und herausfordernde Tätigkeit? Zögern Sie nicht und senden Sie Ihre aussagekräftige Bewerbung (bevorzugt per E- Mail in einer Datei bis 5 MB Größe) unter Angabe der Stellenanzeigen-Nr. ST-19060 an:

Herr Prof. Dr. med. Kaan Boztug

Klinik für Pädiatrische Immunologie und Rheumatologie

Zentrum für Kinder- und Jugendmedizin am Universitätsklinikum Bonn

Venusberg-Campus 1, 53127 Bonn

E-Mail: kaan.boztug@ukbonn.de

Tel.: 0228 287 37852

www.ukbonn.de

The Cluster of Excellence ImmunoSensation² is inviting applications for a PhD student position (m/f/d) (65%) in Cancer Immunology at the Bonn Graduate School of Immunosciences and Infection. The position is initially limited to 3 years.

ImmunoSensation² is a Cluster of Excellence funded by Germany’s Excellence Strategy at the University of Bonn. Participating scientists are dedicated to investigating innate immunity beyond the boundaries of classical immunology. In a joint effort, immunologists, neurobiologists, systems biologists and mathematicians of the University of Bonn and the German Center for Neurodegenerative Diseases (DZNE) of the Helmholtz Association aim to connect the status of the immune system, the metabolism and the nervous system to disease states. ImmunoSensation² is embedded into the outstanding research environment of the University of Bonn, the University Hospital and the DZNE.

Furthermore, ImmunoSensation² is internationally connected and maintains research partnerships with Australia (Melbourne University), Japan (Osaka University, Kyoto University), Brazil (University of Sao Paulo) and the Netherlands (Radboud University, Nijmegen). Students will have the opportunity to receive additional financial support to participate in a student exchange program (3 to 6 months) with selected principal investigators at these partner universities. PhD students will be admitted to the Bonn International Graduate School Immunosciences and Infection. In this structured PhD program, students gain experience with state-of-the-art technologies and become part of a vibrant scientific network and an internationally competitive scientific training program.
 

The ideal candidate will be highly motivated and team-oriented with a strong interest in immunology and tumor biology, have a first-class academic degree in a life science-related discipline (Master’s degree or equivalent), a strong background in immunology, molecular biomedicine, molecular biology, biochemistry or cell biology and enthusiasm for working in the highly-competitive field of cancer immunology research. Candidates should have strong communicative skills (fluent spoken and written English) since these are necessary for work in an international research landscape. Previous hands-on experience in immunological techniques such as multidimensional flow cytometry and in vivo models is desired.

We offer

• The position is part of a joint German Research Foundation (DFG)-funded project
  together with the group of Prof. Dr. Yang Shi at RWTH Aachen, in which state-of-the-art
  nanovesicle engineering will be combined with sophisticated in vivo models to study
  and target T and B cells of the adaptive immune system in the context of cancer
  immunology and cancer immunotherapy (Wang et al., J Control Release 2023,
  Gutiérrez-Melo & Baumjohann, Trends Cancer 2023).
• The salary will be according to the German salary scale TV-L (EG 13)
• Corporate public transport ticket for the VRS (Verkehrsverbund Rhein-Sieg) or the option
  of an interest-free loan for the purchase of an e-bike
• There is also a possibility to use the day care center
• Supplementary benefits in the public sector (pension plan according to VBL)
   

The University of Bonn is committed to diversity and equal opportunity. It is certified as a familyfriendly university. It aims to increase the proportion of women in areas where women are under-represented and to promote their careers in particular. If therefore urges women with relevant qualifications to apply. Applications will be handled in accordance with the Landesgleichstellungsgesetz (State Equality Act). Applications from suitable individuals with a certified serious disability and those of equal status are particularly welcome.
 

Applicants should send their application in a single pdf file (max. 5 MB) including motivation letter, CV, scanned academic degrees, list of publications and the contact details of two references.
 

The successful candidate can begin on September 1st, 2025 or at a later time upon request.
 

Contact

Please send your application by email using the reference number ST-13098 to Prof. Dr. Dirk Baumjohann until June 15th, 2025:
 

Prof. Dr. Dirk Baumjohann
Medical Clinic III for Oncology, Hematology, Immuno-Oncology and Rheumatology
University Hospital Bonn
Venusberg-Campus 1, 53127 Bonn, Germany
Tel: +49 (0)228 287 51185
E-mail: dirk.baumjohann@uni-bonn.de
Website: https://BaumjohannLab.de

We are excited to announce two PhD student positions within the newly funded DFG Research Unit MagNet (Macrophage Niche Network Dynamics).

 The Research Unit MagNet aims to define macrophages as choreographers of tissue development, function, and integrity across different organs. This multidisciplinary consortium explores macrophage biology in health and disease using cutting-edge techniques such as spatial proteomics, 3D imaging, single-cell transcriptomics, and advanced mouse models. For further information see also https://macrophagenetwork.com/.

The two positions are placed in the laboratory of Prof. Stefan Uderhardt at the FriedrichAlexander University (FAU) Erlangen-Nürnberg and the laboratory of Prof. Eva Kiermaier at the University of Bonn/FAU Erlangen-Nürnberg. We are seeking for highly motivated PhD candidates to work at the interface of cell biology and immunology. 

The project of Stefan Uderhardt aims at understanding the role of Macrophage-Fibroblast networks in extracellular matrix homeostasis in vivo, particularly in synovial joints. It focuses on the cooperative interactions between macrophages and fibroblasts in regulating the turnover of extracellular matrix components to maintain tissue homeostasis and prevent inflammatory diseases such as arthritis. Project relevant methods include mouse work, ex vivo and in vitro cell cultures, knockout mouse models, high-dimensional 2D and 3D tissue microscopy, transcriptomics; 2D and 3D coculture systems; AI-driven image reconstruction and quantification. 

The project of Eva Kiermaier aims at deciphering the interrelation between Kupffer cells and hepatocyte polyploidization. It explores how liver-resident macrophages (Kupffer cells) regulate the polyploidization of hepatocytes during early postnatal development, contributing to liver metabolism and function. Project relevant methods unclude ex vivo cell cultures, coculture experiments, conditional knockout mice, advanced live cell imaging and highresolution microscopy, proliferation assays, metabolomics and transcriptomics. 

The applicants should hold a master degree in cell biology, immunology, biochemistry or related fields. We particularly look for applicants with a collaborative attitude towards research and who can combine high personal ambition and work ethics with eagerness to contribute to other projects. We offer enrollment in structured graduate programs, cutting-edge research training in immune cell biology, immunology and quantitative cell biology, a collaborative and interdisciplinary environment with annual retreats, summer schools, international symposiums, and lab exchange opportunities as well as mentoring through Thesis Advisory Committees (TACs) for scientific and professional development.

Complete applications in English should include a CV, a brief statement of research experiences and interests and addresses of two referees. Please submit your application as a single PDF file to Stefan Uderhardt (Stefan.uderhardt@fau.de) or Eva Kiermaier (eva.kiermaier@uni-bonn.de) before April 15th 2025!

The University Hospital Bonn (UKB) is a maximum care hospital with more than 1,300 beds. Our more than 9,000 employees take on tasks in research, teaching and patient care as well as in public health at the highest level. In the science ranking (LOMV) and in the economic result, the UKB is number 1 of the university hospitals in NRW and in 2021 had the third highest case mix index of the university hospitals in Germany.

The Nowak Lab located at the Institute of Structural Biology, University Hospital Bonn, is seeking a 

Postdoctoral Researcher (m/f/d) 

to join our multidisciplinary team on a full-time (38.5 hours/week) position funded by PROXIDRUGs consortium, Germany´s Clusters4Future initiative until Dec 2027. As part of the academic-industry PROXIDRUGs consortium project you will be working with groups of Prof. Ivan Đikić (Geothe University, Frankfurt) Prof. Michael Potente (Berlin Institute of Health/Charite), Prof. Tobias Bopp (Johannes Gutenberg University, Mainz) and AnalytiCon Discovery to discover and validate new proximity inducing small molecules towards challenging transcription factor targets.

Key Responsibilities:

• Develop and validate cellular and in-vitro assays in 96 and 384 well format using CRISPR (HiBiT, protein tagging) or lentiviral stable integration
• Perform small molecule screens (covalent libraries) and use chemical biology to validate MOA
• Collaborate closely with team members on research projects and mentor junior lab members, including technicians, master’s students, and Ph.D. candidates.
• Prepare research findings for publication in high-impact scientific journals and present results at national and international conferences.
• Actively contribute to maintaining

Qualifications:

• A Ph.D. in Chemical Biology, Cell Biology, Molecular Biology, or a related field.
• Proven ability to design, develop, and execute complex small molecule projects, with a strong track record of publications in peer-reviewed journals.
• Experience in drug discovery projects beneficial, but not essential.
• Excellent communication skills (written and verbal) and the ability to work effectively in a collaborative and diverse research environment.
• High level of creativity, self-motivation, organizational skills, and attention to detail.

We offer:

• Adynamic and inspiring research environment with a high level of interdisciplinary collaboration.
• Employment according to TV-L (EG13, 100%), including benefits such as:
  • Company pension scheme and the possibility of aninterest-free loan to buy an e-bike.
  • Access to numerous employee discounts and corporate benefits and free membershipin UKBfit

How to apply:

Are you excited to join the growing team? Do not hesitate and send your detailed application (preferably by e-mail in one file up to 5 MB in size), stating the job advertisement number ST-17019 to:

Prof. Dr. Radosław Nowak

Institute of Structural Biology, University Clinic Bonn

E-Mail: radoslaw.nowak@ukbonn.de