Open Positions

The research group of Laura Surace at Institute of Clinical Chemistry and Clinical Pharmacology at the University Hospital Bonn (UKB), Faculty of Medicine of the Rheinische Friedrich Wilhelms-University Bonn invites applications for

2 PhD positions – Cancer Immunometabolism

The part-time positions (65%) are limited due a project for 3 years.

We are seeking highly motivated candidates with a strong interest in immunology. Our lab is interested in understanding the role of tissue-resident immune cells in tumor development and response to
therapies, by defining their metabolic requirements, phenotype and function and assessing their interplay with the other components of the tumor microenvironment. We specifically focus on the recently identifiedinnate lymphoid cells (ILC) and T cells (Karagiannis F*, Peukert K*, Surace L*, et al. Nature 2022; Surace et al. Nature Immunology 2021; Surace et al. Blood Advances 2021). More information will be found on our website.

The project will investigate how changes in the host metabolism and diet-derived small molecules shape the cellular composition and metabolic features of the tumor microenvironment and the antitumor immunity during tumor onset and progression.

Ultimately the goal is to identify novel therapeutic strategies, including dietary intervention, relevant in the treatment of cancer.

Requirements

• Master degree in life science (biology, biomedicine, molecular medicine or comparable studies) Candidates with experience in immunology, molecular or cell biology and biochemistry are specifically encouraged to apply
• Experience in laboratory working
• Ability to work independently and in a team
• Very good English skills

The candidate will work with mouse models and human samples and apply classical immunological methods but also cutting-edge technologies, such as imaging mass spectrometry, multiplex tissue imaging, metabolomics and extracellular flux analysis. The candidates will have access to various scientific and soft skill trainings.

We offer

• A contract for an initial period of three years, with the possibility of extension.
• The salary according to the German salary scale TV-L EG13
• The possibility to use the day care center
• Supplementary benefits in the public sector (pension plan according to VBL)
• The possibility to work in a motivated team in a thriving research environment

Attractive conditions and benefits, an interdisciplinary research institution that fosters innovation and collaboration and are committed to training and career development of the next generation of scientists.

The University of Bonn is committed to diversity and equal opportunity. It is certified as a family-friendly university. It aims to increase the proportion of women in areas where women are under-represented and to promote their careers in particular. It therefore urges women with relevant qualifications to apply. Applications will be handled in accordance with the Landesgleichstellungsgesetz (State Equality Act). Applications from suitable individuals with a certified serious disability and those of equal status are particularly welcome.

To apply

Applications should include CV, certificates, and contact information of two referees and be send by e-mail under indication of reference number 235_2023 until 1st of June 2023 to:

Dr. Laura Surace

Institute of Clinical Chemistry and Clinical Pharmacology
University Hospital Bonn
University of Bonn
Venusberg-Campus 1
53127 Bonn, Germany
E-Mail: lsurace@uni-bonn.de
www.ukbonn.de/ikckp

The Institute of Molecular Medicine and Experimental Immunology (IMMEI) at the Medical Faculty of the University of Bonn invites applications for a

PhD position – Effects of sex hormones on nucleic acid immunity (m/f/o)

available immediately for three years with the possibility of extension

in the Department of Cellular Immunology (Prof. Natalio Garbi) in the framework of the German Research Council-founded consortium SFB-TRR237 (https://www.trr237.uni-muenchen.de/index.html). The laboratory has a long-standing, internationally recognised track record on basic and applied aspects of cellular immunology and infection and is equipped with high-end instrumentation. The IMMEI has about 50 staff members across 7 independent research groups with over 30 scientists and PhD students (www.immei.de).

The hosting laboratory focusses on diverse aspects of immune regulation including the role of nucleic acid
recognition in the development of autoimmune disease, immune defense mechanisms, and basic aspects of naive T cell activation regulating cell fate. This PhD project extends on our previous findings identifying nucleic acid sensing and macrophages as main mediators of severe ANCA vasculitis, a severe and often-fatal autoimmune disease (Kessler et al, J. Exp. Med. 2022). As a follow up, we observed sex differences in nucleic acid recognition affecting disease outcome. The aim of this project is to disentangle how sex hormones regulate nucleic acid immunity using our vasculitis model as well as preclinical in vivo and in vitro models of viral infection. The student will gain expertise in state-of-theart technologies such as spectral flow cytometry and confocal microscopy, singe-cell mRNAseq, metabolomics, proteomics, lipidomics and standard cellular immunology techniques.

We offer

• Dynamic, multidisciplinary and international environment with a strong focus on immunology. International

• Immunology Training Program (IITB), giving access to state-of-the-art training and workshops on different scientific aspects.

• Weekly seminars on immunology and other biomedical topics by national and international speakers.

• Possibility to present results at national and international conferences.

• Modern university sport facilities.

• Salary according to the German scale TV-L 13 65% with additional benefits in the public sector such as pension plan and UKB corporate benefits.

• Living in an active university city with access to internationally known museums, music and theatre venues and many other cultural possibilities in the Bonn-Cologne area.
  
  

Your profile

• Highly motivated and talented with interest in neuroimmunology.

• Strong work commitment and discipline.

• Diploma or master thesis in immunology, (neuro)biology, biochemistry, biomedicine or similar.

• Ability to work independently and as part of a team.

• Excellent English communication skills.

The University of Bonn is a German University of Excellence since 2019 that is committed to affirmative action for diversity and equal oppurtunities for all. Applications will be handled in accordance with the Landesgleichstellungsgesetz (State Equality Act).

To apply

Please send a motivation letter, CV, two references (or referee’s names and contacts) and degree certificates with grades in one single pdf fileusing reference “NAI23” to Natalio Garbi (ngarbi@uni-bonn.de) by May 31st, 2023.

The Institute of Molecular Medicine and Experimental Immunology (IMMEI) at the Medical Faculty of the University of Bonn invites applications for a

PhD position – Regulation of immunity by sensory neuronal inputs (m/f/o)

available immediately for three years with the possibility of extension

in the Department of Cellular Immunology (Prof. Natalio Garbi) in the framework of the DFG-founded Immunosensation² Bonn cluster of Excellence. The laboratory has a long-standing, internationally recognised track record on basic and applied aspects of cellular immunology and infection and is equipped with high-end instrumentation. The IMMEI has about 50 staff members across 7 independent research groups with over 30 scientists and PhD students (www.immei.de) and is embedded within the campus of the faculty of medicine with outstanding immunology and neurology institutes.

The hosting laboratory focusses on diverse aspects of immune regulation including autoimmunity and infections. The aim of this project is to investigate how the sensorial nervous system regulates immune responses in the lung against microbial infection. The student will work with mouse models and gain expertise in state-of-the-art technologies such as spectral flow cytometry and confocal microscopy, single-cell mRNAseq, metabolomics, proteomics, lipidomics and standard immunology techniques.

We offer

• Dynamic, multidisciplinary and international environment with a strong focus on immunology. International

• Immunology Training Program (IITB), giving access to state-of-the-art training and workshops on different scientific aspects.

• Weekly seminars on immunology and other biomedical topics by national and international speakers.

• Possibility to present results at national and international conferences.

• Modern university sport facilities.

• Salary according to the German scale TV-L 13 65% with additional benefits in the public sector such as pension plan and UKB corporate benefits.

• Living in an active university city with access to internationally known museums, music and theatre venues and many other cultural possibilities in the Bonn-Cologne area.
  
  

Your profile

• Highly motivated and talented with interest in neuroimmunology.

• Strong work commitment and discipline.

• Diploma or master thesis in immunology, (neuro)biology, biochemistry, biomedicine or similar.

• Ability to work independently and as part of a team.

• Excellent English communication skills.

The University of Bonn is a German University of Excellence since 2019 that is committed to affirmative action for diversity and equal oppurtunities for all. Applications will be handled in accordance with the Landesgleichstellungsgesetz (State Equality Act).

To apply

Please send a motivation letter, CV, two references (or referee’s names and contacts) and degree certificates with grades in one single pdf fileusing reference “NeuroImm23” to Natalio Garbi (ngarbi@uni-bonn.de) by May 2nd, 2023.

The University Hospital Bonn

We combine excellence in research, teaching and patient care as well as economic efficiency.

The University Hospital Bonn (UKB) is a maximum care hospital with more than 1,300 beds. Our more than 9,000 employees perform tasks in research, teaching and patient care as well as in public health care at the highest level. The UKB ranks first among university hospitals in North Rhine-Westphalia in the science ranking (LOMV) and in the economic result and had the third highest case mix index of university hospitals in Germany in 2021.

The Advanced Clinician Scientist Program is a joint program of the Medical Faculty of the University of Bonn and the University Hospital Bonn and part of a continuous support structure for medical scientists.

To be filled on January 1, 2024:

2 Advanced Clinician Scientist positions (m/f/d) „Inflammation and Immunopathogenesis“

The Advanced Clinician Scientist Program is aimed at specialist physicians who, in addition to their clinical activities, are engaged in basic, translational or clinical research and wish to pursue a further scientific and clinical career. In addition to an independent research profile, the goal is a close integration of research, teaching and patient care.

The core element is a contractually defined, individually configurable, protected research period over a period of 6 years. Candidates can also participate in an extensive clinical-scientific mentoring and coaching program as well as a qualification program that includes relevant content for an academic career.

External applications are strongly encouraged.

Funding

Funding includes own position at 50% (according to TVA-Ä2) to work on a research project, as well as material resources, travel expenses, an accompanying qualification program and mentoring.

The management of the clinic at which the sponsored person will work bears the financing of the clinical activity. Applicants need a confirmation of employment from the receiving hospital for the funding period as well as a confirmation of release from clinical work (min. 50%) for the research project.

There is the possibility of a co-affiliation with one of the local research institutes and collaborative research centers (SFBs).

After 3 years, an interim evaluation takes place, on the basis of which a decision is made on further funding. After a positive final evaluation, it is possible to take over a professorship with equipment following the funding if all requirements are met.

Eligible to apply for all positions are physicians with:

• Completed residency training (no more than 5 years ago).

• An established and outstanding research profile Scientific publications in the thematic focus of the call.

• Already successfully acquired third-party funding

Application

The application process is two-stage. Positively reviewed project proposals will be presented by the applicants in a public event, probably in the 46th week, and reviewed by an independent panel.

The English-language application is exclusively via the eApplication portal and is possible until August 15th, 2023.

Further information about the Advanced Clinician Scientist program and the required application documents can be found on the website. From there, you can also access the eApplication portal.

If you have any questions, please contact the Coordination Office for Internal Funding (Int.Foerderung@ukbonn.de).

We are committed to diversity and equal opportunities. Our aim is to increase the proportion of women in areas where women are underrepresented and to give special support to their careers. We therefore strongly encourage applications from relevantly qualified women. Applications will be handled in accordance with the State Equal Opportunity Act. Applications from suitable persons with proven severe disabilities and persons treated as such are particularly welcome.

Contact

Coordination Internal Promotion

PD Dr. Ildikó Racz / Dr. Dorothea Schmitt

University Hospital Bonn

Venusberg-Campus-1

53127 Bonn

E-mail: Int.Foerderung@ukbonn.de

Mobile: +49 151 18853678

www.ukbonn.de