Open Positions

We are currently inviting applications for a

Postdoc (m/f/d) in Biomathematics – Systems Biology of Inflammation

at the Interdisciplinary Research Unit Mathematics in the Life Sciences. The full-time position will start in April 2023 or as early as possible thereafter, for a period of three years due a project with the possibility of extension.

The mammalian immune response depends on the interaction and collaboration of many highly individual cells. The group of Prof. Dr. Kevin Thurley uses mathematical modeling and data analysis tools to quantify and rationalize immune cell dynamics in the context of clinical manifestations such as chronic inflammation and cancer. The group is integrated into both the ImmunoSensation and the Hausdorff Mathematics Clusters of Excellence, an exceptional environment for our interdisciplinary research program.

In the available project, we will design and analyze data-driven spatio-temporal models of cell-cell communication networks in the tumor micro-environment. The project will be carried out in tight collaboration with wet-lab immunologists and will include first-hand data analysis as well as mathematical model development. The project will comprise data-driven spatial modelling techniques and deep-learning methods that will partly be developed and adapted within the project, thus offering ample opportunity for expert training in state-of-the-art systems immunology.

In the available project, we will design and analyze data-driven spatio-temporal models of cell-cell communication networks in the tumor micro-environment. The project will be carried out in tight collaboration with wet-lab immunologists and will include first-hand data analysis as well as mathematical model development. The project will comprise data-driven spatial modelling techniques and deep-learning methods that will partly be developed and adapted within the project, thus offering ample opportunity for expert training in state-of-the-art systems immunology.

We are looking for highly motivated, independent and committed scientists eager to make significant contributions to both fundamental and clinic-oriented research. Applicants should hold a PhD degree in (bio-)physics, computational biology, mathematics, computer science, or a related discipline, and should have documented experience in spatio-temporal modelling techniques. Very good computer programming skills are required, training in immunology or cell biology is an advantage. The position requires good communication and interpersonal skills, and fluent English. For more information, visit https://www.thurleylab.org.

We offer

• A stimulating, multidisciplinary research environment at the interface of immunology and biomathematics
• A salary according to the German salary scale TV-L E13
• A “Jobticket” (subsidized public transport) is available
• There is also a possibility to use the day care center
• Supplementary benefits in the public sector (pension plan according to VBL)

The University of Bonn is committed to diversity and equal opportunity. It is certified as a family-friendly university. It aims to increase the proportion of women in areas where women are under-represented and to promote their careers in particular. It therefore urges women with relevant qualifications to apply. Applications will be handled in accordance with the Landesgleichstellungsgesetz (State Equality Act). Applications from suitable individuals with a certified serious disability and those of equal status are particularly welcome.

Contact information

Applications should include a brief statement on research interests, a CV, and contact information for three referees, compiled into a single pdf file. Please send in applications until 12.03.2023 by email, quoting the reference number [38_2023].

Prof. Dr. Kevin Thurley

IEO-Biomathematics

University of Bonn Medical School

Venusberg-Campus 1

53127 Bonn

E-Mail: kevin.thurley@ukbonn.de

www.thurleylab.org

The research group “Cellular Virology” at the Faculty of Medicine of the Rheinische Friedrich Wilhelms-University Bonn invites applications for a

PhD Student position in infection biology (m/f/d)

The position (65 %) is available for a period of 3 years due a project, with the possibility of extension.
We are seeking a highly motivated candidate to fill a Ph.D. student position in infection biology in the research group “Cellular Virology” under the direction of Jun.- Prof. Dr. Stephanie Jung.

The research focus of the "Cellular Virology" group localizes in interdisciplinary basic research. It covers the interface between virology, immunology, RNA biology and the new, highly innovative topic of extracellular vesicles. Using both classical and self-developed methods from all these fields, we explore diverse mechanisms, which activate and inhibit innate immune signaling. These innate defense processes are evolutionary conserved pathways, which restrict viral replication and spread. However, innate immunity itself must also be fine-tuned to cellular requirements to prevent damage to the organism by the antiviral mechanisms themselves. In the context of the advertised position, cellular regulatory mechanisms of innate immunity will be investigated.

Please find more information about our group and our research below:

homepage - AG Jung

research - How danger signaling is amplified in Influenza A-virus infected cells

research - Designing a specific TLR8 agonist

The group is part of the Institute of Cardiovascular Immunology and embedded in the Cluster of Excellence ImmunoSensation² in Bonn and offers an excellent environment for young researchers. The PhD position will be integrated into the local graduate program BIGS Immunosciences and Infection with outstanding training opportunities in multidisciplinary, interconnected scientific fields and supported by the additional mentoring and networking opportunities. PhD students will benefit from state-of-the-art technologies, high-end laboratories, a vibrant scientific network and an internationally competitive scientific training program.

Requirements:

• Master or diploma in life science
  (Biology, biomedicine, molecular medicine or comparable studies)
• Profound knowledge in basic molecular biological methods and cell culture
• Experience in working with RNA and / or infection biology methods would be ideal
• Ability to work independently and in a team
• Excellent management and communication skills
• Strong ability to draw logical conclusions
• High intrinsic motivation and enthusiasm as well as a deep interest in Biomedicine and
  infection biology
• English or German skills at C1 level or higher
• Experienced handling of MS Office applications

We offer:

• A salary according to the German salary scale TV-L E13
• Corporate customer ticket (subsidized public transport) is available
• Possibility to use the day care centre
• Supplementary benefits in the public sector (pension plan according to VBL)
• A diverse and demanding job with one of the largest employers in the region
• An innovative research area with an extremely collegial approach and many
  possibilities for novel discoveries and development of your own ideas
• A good methodical education and excellent supervision in a small friendly group
• Best possible support in your professional development
• Possibility for further education in university and non-university courses
  

The University of Bonn is committed to diversity and equal opportunity. It is certified as a family-friendly university. It aims to increase the proportion of women in areas where women are under-represented and to promote their careers in particular. It therefore urges women with relevant qualifications to apply. Applications will be handled in accordance with the Landesgleichstellungsgesetz (State Equality Act). Applications from suitable individuals with a certified serious disability and those of equal status are particularly welcome.

If you are interested in the position, please send your application as a single pdf-file including a cover letter, curriculum vitae, university-entrance certificate, university certificates and the contact details of two references. Applications should be send by email until 16.04.2023 under indication of reference number 183_2023 to:

Jun.-Prof. Dr. Stephanie Jung

“Cellular Virology”

Institute of Cardiovascular Immunology

University Hospital Bonn

Venusberg-Campus 1

53127 Bonn

Email: sjung@uni-bonn.de