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featured publications

  • Discovery of Histone Deacetylase 8-Specific Proteolysis-Targeting Chimeras with Anticancer Activity against Hematological Malignancies.

    Journal of medicinal chemistry

    Authors: Shiyang Zhai, Marie Kemkes, Cindy-Esther Kponomaizoun, Jan Gerhartz, Felix Feller, Jia-Wey Tu, Dominika Ewa Pieńkowska, Julian Schliehe-Diecks, Ina Dressel, Michael Gütschow, Radosław P Nowak, Christian Steinebach, Sanil Bhatia, Finn K Hansen

  • Lymphotoxin-dependent elevated meningeal CXCL13:BAFF ratios drive gray matter injury.

    Nature immunology

    Authors: Ikbel Naouar, Andrei Pangan, Michelle Zuo, Syed Ali Raza, Kevin Champagne-Jorgensen, Jyot Patel, Angela Wang, Annie Pu, Lesley Ward, Jennifer S Y Ahn, Faizah N Sayeed, Jingwen Zhu, Elisabeth Pössnecker, Shoshana Spring, John G Sled, Bruno Cenni, Barbara Nuesslein-Hildesheim, Jeffrey L Browning, Anne-Katrin Pröbstel, Daniel S Reich, Jennifer L Gommerman, Valeria Ramaglia

  • Systemically inducing trained immunity overcomes solid tumors' immunosuppressive microenvironment.

    Science advances

    Authors: Bram Priem, Lisa Willemsen, Tom Anbergen, Yuri van Elsas, Jeroen Deckers, David P Schrijver, Stijn R J Hofstraat, Iris V Messing, Jazz Munitz, Dionne Honing, Geoffrey Prévot, Yohana C Toner, Judit Morla, William Wang, Anna Ranzenigo, Isabella Sirchia, Tomas Post, Raphaël Duivenvoorden, Ewelina Kluza, Glenn A O Cremers, Joost H C M Kreijtz, Carlos Pérez-Medina, Mandy M T van Leent, Abraham J P Teunissen, Roy van der Meel, Yi Zhou, Chris Glass, Jordi Ochando, Leo A B Joosten, Zahi A Fayad, Romana T Netea-Maier, Mihai G Netea, Menno P J de Winther, Thijs J Beldman, Arjan W Griffioen, Willem J M Mulder

  • Anti-IL-18 immunotherapy decreases inflammatory and vaso-occlusive responses in mice with sickle cell disease.

    Experimental hematology

    Authors: Érica M F Gotardo, Lidiane S Torres, Irmgard Förster, Lucas F S Gushiken, Pâmela L Brito, Flavia C Leonardo, Bruna Cunha Zaidan, Andreas Bruederle, Sergei Agoulnik, Jiri Kovarik, John Millholland, Fernando F Costa, Nicola Conran

  • Olfr2 Promotes Recruitment of Monocytes via CX3CR1 in Abdominal Aortic Aneurysm.

    Circulation research

    Authors: Patrik Schelemei, Felix Simon Ruben Picard, Yein Park, Philipp Wollnitzke, Harshal Nemade, Sebastian Karl Lechner, Dennis Mehrkens, Per Arkenberg, Anna Christine Koebele, Jan Wrobel, Kristel Martinez Lagunas, Elena Wagner, Henning Guthoff, Alexander Hof, Khalia Cummings, Muntadher Al Zaidi, Sebastian Zimmer, Joy Roy, Moritz Lindquist Liljeqvist, Dennis Wolf, Thomas Riffelmacher, Wiebke Ibing, Markus U Wagenhäuser, Hubert Schelzig, Bodo Levkau, Ulrich Flögel, Norbert Gerdes, Mohammad Karimpour, Axel M Hillmer, Gerhard Sengle, Remco T A Megens, Christian Weber, Marco Orecchioni, Stephan Baldus, Martin Mollenhauer, Holger Winkels

  • Kupffer cells control neonatal hepatic metabolism via Igf1 signaling.

    Development (Cambridge, England)

    Authors: Nikola Makdissi, Daria Hirschmann, Aleksej Frolov, Inaam Sado, Bastian Bennühr, Fabian Nikolka, Jingyuan Cheng, Nelli Blank-Stein, Maria Francesca Viola, Mohamed Yaghmour, Philipp Arnold, Lorenzo Bonaguro, Matthias Becker, Christoph Thiele, Felix Meissner, Karsten Hiller, Marc D Beyer, Elvira Mass

  • Initiation of a global consortium to study the progression of age-related macular degeneration: RIMR AMD consortium report # 1.

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    Authors: Srinivas R Sadda, Charles C Wykoff, Itay Chowers, Jean-Francois Korobelnik, Raja Narayana, Rajeev R Pappuru, Frank G Holz, Robyn Guymer, Chui Ming Gemmy Cheung, David S Boyer, Michael Ip, Heiko G Niessen, Nancy Holenkamp, Mary Durbin, Stephanie Magazzeni, Anne-Marie Cairns, Carlos Ciller, Natasa Jovic, Joseph Blair, Sandro De Zanet, Aaron Y Lee

  • Adenophages are an atypical macrophage population in exocrine glands sustained by ILC2-derived GM-CSF.

    Nature immunology

    Authors: Frederike Westermann, Selma Tuzlak, Victor Kreiner, Aline Ignacio, David Bejarano, Mitchell Bijnen, Virginia Cecconi, Hannah van Hove, Haiting Wang, Myrto Andreadou, Gioana Litscher, Colin Sparano, Ricardo Fróis-Martins, Alexandre Gallerand, Elsa Roussel, Laura Oberbichler, Rachel Lindemann, Donatella DeFeo, Zhaoyuan Liu, Anja Kipar, Salomé LeibundGut-Landmann, Kathy McCoy, Iain Nixon, Calum C Bain, Christoph Schneider, Stoyan Ivanov, Sonia Tugues, Melanie Greter, Florent Ginhoux, Andreas Schlitzer, Elaine Emmerson, Burkhard Becher

  • Exome sequencing points to pathogenic ATM variants in gastric cancer.

    European journal of human genetics : EJHG

    Authors: Laura L Koebbe, Timo Hess, Stephan L Haas, Ines Gockel, Guillaume Piessen, Anna Latiano, Carina Pereira, Ewa Malecka-Wojciesko, Anna Mokrowiecka, Stefania Boccia, Marek Majewski, Hakan Alakus, Ángel Lanas, Roberta Pastorino, Thorsten Oliver Goetze, Peter Elbe, Nicole Kreuser, Orazio Palmieri, Francesca Tavano, Christiane Josephine Bruns, Olivier Glehen, Xavier B D'Journo, Caroline Gronnier, Jean M Fabre, Laurent Sulpice, Luis Bujanda, Leticia Moreira, Stefanie Heilmann-Heimbach, Maximilian Billmann, Markus M Noethen, Renato Cannizzaro, Michele Ghidini, Lutz Hamann, Nuria Aragones, Mário Dinis-Ribeiro, Rui Medeiros, Salah-Eddin Al-Batran, Mārcis Leja, Juozas Kupcinskas, María A García-González, Carlo Maj, Marino Venerito, Johannes Schumacher

  • Five-Year Experience of Haemophilia Centre Certification Performed by the German, Austrian and Swiss Society for Thrombosis and Haemostasis Research.

    Haemophilia : the official journal of the World Federation of Hemophilia

    Authors: Hermann Eichler, Hagen Bönigk, Susan Halimeh, Christina Hart, Judith Hörner, Robert Klamroth, Ralf Knöfler, Christoph Königs, Thomas Lang, Florian Langer, Wolfgang Miesbach, Johannes Oldenburg, Ramona Oral, Martin Olivieri, Christian Pfrepper, Jan Pilch, Ute Scholz, Werner Streif, Manuela Albisetti