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Dr. Melania Capasso

Member, Steering-Committee Member

German Center for Neurodegenerative Diseases (DZNE)

Venusberg-Campus 1/99 53127 Bonn

melania.capasso@dzne.de

+49 228 43302325

Website

My group is interested in elucidating pathways regulating immune cell function in ageing and neurodegenerative diseases, with a particular focus on myeloid cells, the components of the innate immune system.

In particular, we are interested in understanding the changes that characterize immune cells, such as microglia and neutrophils, with age and in Alzheimer’s disease, with the scope of identifying new pathways and molecular targets that can lead to therapeutic interventions.

Melania Capasso

Recent publications

  • Microglia activation by derepression of endogenous retroviruses drives inflammation and cellular senescence.

    Nature neuroscience

    Authors: Xin Yan, Christina Georgopoulou, Hang-Mao Lee, Ala Ahrari, Jenny Russ, Vijay Chandrasekar, Tim Ducksch, Giuliano Crispatzu, Valentina Talevi, Liang Qiao, Shobhit Agrawal, Sophie Crux, Andrew W Daman, Lena Wischhof, Miriam Stork, Margit Zweyer, Emma Dorotea Zanfi, Manon Chevallot-Beroux, Yunxiao Li, Elena De-Domenico, Dina Hüsson, Lorenzo Bonaguro, Yuanfang Li, Jonas Schulte-Schrepping, Qingyi Liang, Ketty Kessler, Dan Ehninger, Shahin Rafii, Jiankai Luo, Andreas Hermann, Annett Halle, Ying Liu, Elvira Mass, Melania Capasso, Hiroki Kato, Joachim L Schultze, Pierluigi Nicotera, Daniele Bano, Steven Zvi Josefowicz, Martin Fuhrmann, Thomas Ulas, Marc Beyer, Juntang Lin, Monique M B Breteler, N Ahmad Aziz, Paolo Salomoni

  • Long-term rapamycin treatment suppresses IL-17-producing gamma delta T cells and blunts neuroinflammation in aging.

    PloS one

    Authors: Clement Torrent, Caterina Gagliardi, Nina Fülle, Ignazio Antignano, Maria Eugenia Bernis, Miriam Stork, Daniele Bano, Melania Capasso, Lily Keane

  • Single cell whole-genome sequencing of brain cells: age- and cell-type specific mutational profiles.

    Signal transduction and targeted therapy

    Authors: Melania Capasso, N Ahmad Aziz

All publications by Dr. Melania Capasso