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Dr. Nicole Glodde


Institute of Experimental Oncology

+49 228 28751192


The overarching aim of my group is to understand the principles of resistance to cancer immunotherapies and to investigate the complex and dynamic interplay between tumor and immune cells in order to develop innovative and effective immunotherapeutic approaches that will improve the treatment of cancer patients. To achieve this, we are using preclinical cancer mouse models and patient-derived tumor material, employing cutting-edge genome editing and bioengineering technologies in combination with high-dimensional imaging approaches.

Recent publications

  • ICOS DNA methylation regulates melanoma cell-intrinsic ICOS expression, is associated with melanoma differentiation, prognosis, and predicts response to immune checkpoint blockade.

    Biomarker research

    Authors: Damian J Ralser, Emmanuelle Herr, Luka de Vos, Zsófi Kulcsár, Romina Zarbl, Niklas Klümper, Gerrit H Gielen, Alexander Philippe Maas, Friederike Hoffmann, Jörn Dietrich, Pia Kuster, Alexander Mustea, Nicole Glodde, Glen Kristiansen, Sebastian Strieth, Jennifer Landsberg, Dimo Dietrich

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  • Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma.

    Journal for immunotherapy of cancer

    Authors: Luiza Martins Nascentes Melo, Dayana Herrera-Rios, Daniel Hinze, Stefanie Löffek, Irem Oezel, Roberta Turiello, Juliane Klein, Sonia Leonardelli, Isa-Vanessa Westedt, Yahya Al-Matary, Sara Egea-Rodriguez, Alexandra Brenzel, Maja Bau, Antje Sucker, Eva Hadaschik, Florian Wirsdörfer, Helmut Hanenberg, Niklas Uhlenbrock, Daniel Rauh, Joanna Poźniak, Florian Rambow, Jean-Christophe Marine, Maike Effern, Nicole Glodde, Dirk Schadendorf, Jadwiga Jablonska, Michael Hölzel, Iris Helfrich

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  • Targeting inflamed and non-inflamed melanomas: biological background and clinical challenges.

    Seminars in cancer biology

    Authors: Alice Indini, Daniela Massi, Matteo Pirro, Fausto Roila, Francesco Grossi, Amirhossein Sahebkar, Nicole Glodde, Tobias Bald, Mario Mandalà

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