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Dr. Nicole Glodde

Member

Institute of Experimental Oncology

nicole.glodde@ukbonn.de

+49 228 28751192

Website

The overarching aim of my group is to understand the principles of resistance to cancer immunotherapies and to investigate the complex and dynamic interplay between tumor and immune cells in order to develop innovative and effective immunotherapeutic approaches that will improve the treatment of cancer patients. To achieve this, we are using preclinical cancer mouse models and patient-derived tumor material, employing cutting-edge genome editing and bioengineering technologies in combination with high-dimensional imaging approaches.

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Recent publications

  • Longitudinal spatial neutrophil profiling during ACT in murine melanoma reveals distinct lymph node infiltration patterns.

    NPJ systems biology and applications

    Authors: Gemma van der Voort, Maike Effern, Michelle C R Yong, Lukas Kiwitz, Roberta Turiello, Sonia Leonardelli, Susanna Ng, Dillon Corvino, Tobias Bald, Nicole Glodde, Kevin Thurley, Jan Hasenauer, Michael Hölzel

  • ICOS DNA methylation regulates melanoma cell-intrinsic ICOS expression, is associated with melanoma differentiation, prognosis, and predicts response to immune checkpoint blockade.

    Biomarker research

    Authors: Damian J Ralser, Emmanuelle Herr, Luka de Vos, Zsófi Kulcsár, Romina Zarbl, Niklas Klümper, Gerrit H Gielen, Alexander Philippe Maas, Friederike Hoffmann, Jörn Dietrich, Pia Kuster, Alexander Mustea, Nicole Glodde, Glen Kristiansen, Sebastian Strieth, Jennifer Landsberg, Dimo Dietrich

  • Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma.

    Journal for immunotherapy of cancer

    Authors: Luiza Martins Nascentes Melo, Dayana Herrera-Rios, Daniel Hinze, Stefanie Löffek, Irem Oezel, Roberta Turiello, Juliane Klein, Sonia Leonardelli, Isa-Vanessa Westedt, Yahya Al-Matary, Sara Egea-Rodriguez, Alexandra Brenzel, Maja Bau, Antje Sucker, Eva Hadaschik, Florian Wirsdörfer, Helmut Hanenberg, Niklas Uhlenbrock, Daniel Rauh, Joanna Poźniak, Florian Rambow, Jean-Christophe Marine, Maike Effern, Nicole Glodde, Dirk Schadendorf, Jadwiga Jablonska, Michael Hölzel, Iris Helfrich

All publications by Dr. Nicole Glodde