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Jun.-Prof. Dr. Marie-Christine Simon


Institute of Nutrition and Food Sciences

Nutritional Physiology, Faculty of Agriculture, University of Bonn Nussallee 9

+49 228 733814


We are interested to investigate the link between diet, gut microbiota and cognition, since consumption of a Western diet rich in fat (>34%) and sugars with high glycemic load (19% of total energy) may lead to obesity, type 2 diabetes mellitus and cardiovascular disease. Furthermore, the “microbiota-gut-brain axis” has recently been proposed as a mechanistic link in the development of cognitive functions. According to this hypothesis, dietary behavior may be a critical factor in the development and maintenance of cognitive function. In this regard, our goal is to translate current findings from animal and observational studies into human intervention studies with a translational approach to elucidate this complex interaction of diet, microbiota and brain.

Marie-Christine Simon

Recent publications

  • Impact of the gut microbiome composition on social decision-making.

    PNAS nexus

    Authors: Marie Falkenstein, Marie-Christine Simon, Aakash Mantri, Bernd Weber, Leonie Koban, Hilke Plassmann

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  • Impact of Synbiotic Intake on Liver Metabolism in Metabolically Healthy Participants and Its Potential Preventive Effect on Metabolic-Dysfunction-Associated Fatty Liver Disease (MAFLD): A Randomized, Placebo-Controlled, Double-Blinded Clinical Trial.


    Authors: Aakash Mantri, Anika Köhlmoos, Daniela Stephanie Schelski, Waldemar Seel, Birgit Stoffel-Wagner, Peter Krawitz, Peter Stehle, Jens Juul Holst, Bernd Weber, Leonie Koban, Hilke Plassmann, Marie-Christine Simon

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  • Effect of replacing soybean meal with Hermetia illucens meal on cecal microbiota, liver transcriptome, and plasma metabolome of broilers.

    Poultry science

    Authors: Simone Beller, Sarah M Grundmann, Klara Pies, Erika Most, Sven Schuchardt, Waldemar Seel, Marie-Christine Simon, Klaus Eder, Robert Ringseis

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