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Jun. Prof. Dr. Niels Lemmermann

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Institute for Virology

University Hospital Bonn Venusberg-Campus 1, 53127 Bonn

lemmermann@uni-bonn.de

+49 228 28753445

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The host-specific cytomegaloviruses (CMV) are large DNA viruses of the beta herpesvirus family. After acute infection, CMV genomes remain in a state of replicative latency in host tissues for life, interrupted by episodes of transcriptional reactivation. The establishment of latency is the result of a long period of co-evolution between CMV and its host. During this time, the virus and host have developed a fine balance of immune evasion and immune control to maintain latency. Under conditions of immunosuppression, productive infection can occur by reactivation of the productive cycle of latent genomes. Primary infection or reactivation can lead to life-threatening diseases, e.g. interstitial pneumonia in immunocompromised patients after haematopoietic (stem) cell transplantation (HCT).

The main research topic of our group is to study the establishment of acute and latent CMV infection in a mouse model. We aim to understand the molecular and immunological basis of CMV control by the immune system and the viral countermeasures that lead to the establishment of latency.

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Recent publications

  • Protocol for mapping murine transcription factor interactomes and composite motifs combining affinity purification mass spectrometry and ChIP-seq.

    STAR protocols

    Authors: Anna Gabele, Mert Cihan, Maximilian Sprang, Matthias Klein, Assel Nurbekova, Karolina Romaniuk, Niels Lemmermann, Stefan Tenzer, Miguel A Andrade-Navarro, Tobias Bopp, Ute Distler

  • Unveiling IRF4-steered regulation of context-dependent effector programs in CD4 T cells under Th17- and Treg-skewing conditions.

    Cell reports

    Authors: Anna Gabele, Maximilian Sprang, Mert Cihan, Mareen Welzel, Assel Nurbekova, Karolina Romaniuk, Sarah Dietzen, Matthias Klein, Georg Bündgen, Maxim Emelianov, Gregory Harms, Krishnaraj Rajalingam, Tanja Ziesmann, Katrin Pape, Beatrice Wasser, David Gomez-Zepeda, Kathrin Braband, Michael Delacher, Niels Lemmermann, Stefan Bittner, Miguel A Andrade-Navarro, Stefan Tenzer, Katja Luck, Tobias Bopp, Ute Distler

  • SARS-CoV-2 surveillance in a hospital and control of an outbreak on a geriatric ward using whole genome sequencing.

    Infection prevention in practice

    Authors: Hanno Schmidt, Niels Lemmermann, Matthias Linke, Sven-Ernö Bikár, Stefan Runkel, Susann Schweiger-Seemann, Susanne Gerber, André Michel, Thomas Hankeln, Marina Veith, Wolfgang Kohnen, Bodo Plachter

All publications by Jun. Prof. Dr. Niels Lemmermann