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Jun. Prof. Dr. Niels Lemmermann

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Institute for Virology

University Hospital Bonn Venusberg-Campus 1, 53127 Bonn

lemmermann@uni-bonn.de

+49 228 28753445

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The host-specific cytomegaloviruses (CMV) are large DNA viruses of the beta herpesvirus family. After acute infection, CMV genomes remain in a state of replicative latency in host tissues for life, interrupted by episodes of transcriptional reactivation. The establishment of latency is the result of a long period of co-evolution between CMV and its host. During this time, the virus and host have developed a fine balance of immune evasion and immune control to maintain latency. Under conditions of immunosuppression, productive infection can occur by reactivation of the productive cycle of latent genomes. Primary infection or reactivation can lead to life-threatening diseases, e.g. interstitial pneumonia in immunocompromised patients after haematopoietic (stem) cell transplantation (HCT).

The main research topic of our group is to study the establishment of acute and latent CMV infection in a mouse model. We aim to understand the molecular and immunological basis of CMV control by the immune system and the viral countermeasures that lead to the establishment of latency.

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Recent publications

  • B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the antiviral CD8 T-cell response.

    Cellular & molecular immunology

    Authors: Xinyuan Liu, Filiz Demircik, Mariia Antipova, Emmanouil Stylianakis, Matthias Klein, David Bejarano, Abdelrahman Elwy, Anna Ebering, Michaela Blanfeld, Katlynn Carter, Lisa Johann, David C Uhlfelder, Elisa Blickberndt, Yao Chen, Hans Christian Probst, Nadine Hövelmeyer, Tobias Bopp, Ramon Arens, Lukas Bunse, Joke M M den Haan, Jennifer L Gommerman, Esther von Stebut, Björn E Clausen, Andreas Schlitzer, Karl S Lang, Bing Su, Ronald A Backer, Niels A Lemmermann, Ari Waisman

  • B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the antiviral CD8+ T-cell response

    Cellular & Molecular Immunology

    Authors: Xinyuan Liu, Filiz Demircik, Mariia Antipova, Emmanouil Stylianakis, Matthias Klein, David Bejarano, Abdelrahman Elwy, Anna Ebering, Michaela Blanfeld, Katlynn Carter, Lisa Johann, David C. Uhlfelder, Elisa Blickberndt, Yao Chen, Hans Christian Probst, Nadine Hövelmeyer, Tobias Bopp, Ramon Arens, Lukas Bunse, Joke M. M. den Haan, Jennifer L. Gommerman, Esther von Stebut, Björn E. Clausen, Andreas Schlitzer, Karl S. Lang, Bing Su, Ronald A. Backer, Niels A. Lemmermann, Ari Waisman

  • Protocol for mapping murine transcription factor interactomes and composite motifs combining affinity purification mass spectrometry and ChIP-seq.

    STAR protocols

    Authors: Anna Gabele, Mert Cihan, Maximilian Sprang, Matthias Klein, Assel Nurbekova, Karolina Romaniuk, Niels Lemmermann, Stefan Tenzer, Miguel A Andrade-Navarro, Tobias Bopp, Ute Distler

All publications by Jun. Prof. Dr. Niels Lemmermann