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Prof. Dr. Dagmar Wachten

Member, Steering-Committee Member

Institute of Innate Immunity

Venusberg - Campus 1 53127 Bonn

dwachten@uni-bonn.de

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We aim to understand how cilia work and what their function is. Cilia are subcellular compartments that protrude from the surface of almost every mammalian cell. Cilia can be grouped into two major classes: a) primary cilia, which are immotile and b) motile cilia, which are also called flagella. A prominent example for the latter are sperm flagella. Ciliary dysfunction leads to severe diseases commonly referred to as ciliopathies. They comprise e.g. polycystic kidney disease, obesity, blindness, and infertility. However, the signaling pathways controlling ciliary function are ill-defined. To study ciliary signaling with high spatial and temporal precision, we combine optogenetics and genetically-encoded biosensors with high-resolution microscopy, mouse genetics, and biochemistry. This multidisciplinary approach allows not only to investigate ciliary signaling, but can be applied to any subcellular compartment to study its function with spatial and temporal resolution.

Dagmar Wachten

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Recent publications

  • Macrophages in metaflammation - fueling chronic inflammation in metabolic disease.

    Pflugers Archiv : European journal of physiology

    Authors: Ronja Kardinal, Dagmar Wachten

  • Shiny-Calorie: a context-aware application for indirect calorimetry data analysis and visualization using R.

    Bioinformatics advances

    Authors: Stephan Grein, Tabea Elschner, Ronja Kardinal, Johanna Bruder, Akim Strohmeyer, Karthikeyan Gunasekaran, Jennifer Witt, Hildigunnur Hermannsdóttir, Janina Behrens, Mueez U-Din, Jiangyan Yu, Gerhard Heldmaier, Renate Schreiber, Jan Rozman, Markus Heine, Ludger Scheja, Anna Worthmann, Joerg Heeren, Dagmar Wachten, Kerstin Wilhelm-Jüngling, Alexander Pfeifer, Jan Hasenauer, Martin Klingenspor

  • Primary cilia signalling at a glance.

    Journal of cell science

    Authors: Dagmar Wachten, Søren Tvorup Christensen

All publications by Prof. Dr. Dagmar Wachten