Skip to main content

Prof. Dr. Dagmar Wachten

Member, Steering-Committee Member

Institute of Innate Immunity

Venusberg - Campus 1 53127 Bonn

dwachten@uni-bonn.de

Website

We aim to understand how cilia work and what their function is. Cilia are subcellular compartments that protrude from the surface of almost every mammalian cell. Cilia can be grouped into two major classes: a) primary cilia, which are immotile and b) motile cilia, which are also called flagella. A prominent example for the latter are sperm flagella. Ciliary dysfunction leads to severe diseases commonly referred to as ciliopathies. They comprise e.g. polycystic kidney disease, obesity, blindness, and infertility. However, the signaling pathways controlling ciliary function are ill-defined. To study ciliary signaling with high spatial and temporal precision, we combine optogenetics and genetically-encoded biosensors with high-resolution microscopy, mouse genetics, and biochemistry. This multidisciplinary approach allows not only to investigate ciliary signaling, but can be applied to any subcellular compartment to study its function with spatial and temporal resolution.

Dagmar Wachten

Download biosketch

Recent publications

  • HTZ-1/H2A.Z expression sustains transcriptional programs that regulate Caenorhabditis elegans lifespan.

    Mechanisms of ageing and development

    Authors: Beijia Xie, Enzo Scifo, Ioanna-Maria Menegatou, Rossella Erminia Ciliberti, Mrityunjoy Mondal, Yiru Wang, Antonia Piazzesi, Jialu Hu, Elena De Domenico, Stefan Paulusch, Diego De Stefani, Matthias Schmid, Dagmar Wachten, Marc D Beyer, Pierluigi Nicotera, Nasir Ahmad Aziz, Dan Ehninger, Daniele Bano

  • Modelling kidney cystogenesis using human kidney tubuloid cultures.

    BMC molecular and cell biology

    Authors: Jana Rohe, Arsila Palliyulla Kariat Ashraf, Melina Kehl, Xenia Thielmann, Jörg Ellinger, Glen Kristiansen, Dagmar Wachten, Marieta Ioana Toma

  • Endothelial ADGRF5(GPR116) governs vascular adaptation required for sustained thermogenic remodeling of brown adipose tissue.

    Molecular metabolism

    Authors: Rabih El-Merahbi, Vasiliki Karagiannakou, Ronja Kardinal, Lea Seep, Richard Lindner, Michelle Ynonne Jäckstein, Staffan Hildebrand, Mersiha Hasic, Eylül Korkmaz, Ankush Kumar Jha, Aspasia Thodou Krokidi, Kenneth Dyar, Felix Meissner, Stephan Grein, Jörg Heeren, Martin Klingenspor, Alexander Pfeifer, Jan Hasenauer, Dagmar Wachten, Stephan Herzig, Anastasia Georgiadi

All publications by Prof. Dr. Dagmar Wachten