The main objective of Dr. Ramirez’s laboratory is the identification of the genetic and epigenetic architecture that influences the disease processes underlying cognitive disorders such as Alzheimer’s disease. A key focus of his research is identifying the molecular mechanisms at the intersection of ageing and Alzheimer’s disease that drive cognitive decline. His group combines (epi)genomics and proteomics to study cellular senescence, a key mechanism that triggers chronic inflammation through the senescence-associated secretory phenotype (SASP).
Recent publications
Pathways to resilience: relationships between cognitive reserve, psychological debt, and Alzheimer's disease biomarkers.
Alzheimer's research & therapy
Authors:
Hanna Boscheck, Maxie Luft, René Mauer, Selin Senguel, Ylenia D'elia, Peter Dechent, Klaus Fliessbach, Wenzel Glanz, Stefan Hetzer, Daniel Janowitz, Ingo Kilimann, Luca Kleineidam, Marie Kronmüller, Falk Lüsebrink, Lukas Preis, Boris Rauchmann, Ayda Rostamzadeh, Björn Hendrik Schott, Sebastian Sodenkamp, Eike Spruth, Sophia Stoecklein, Renat Yakupov, Gabriel Ziegler, Frederic Brosseron, Katharina Buerger, Julian Hellmann-Regen, Christoph Laske, Robert Perneczky, Oliver Peters, Josef Priller, Alfredo Ramirez, Anja Schneider, Annika Spottke, Stefan Teipel, Jens Wiltfang, Frank Jessen, Emrah Düzel, Sandra Röske, Michael Wagner, Franka Glöckner, Natalie L Marchant, Olga Klimecki, Miranka Wirth
GWAS meta-analysis of cerebrospinal fluid Alzheimer's biomarkers reveals loci regulating lipids, brain volume and autophagy.
Nature communications
Authors:
Jigyasha Timsina, Chenyang Jiang, Daniel L McCartney, Feifei Tao, Maria Carolina Dalmasso, Jenna Najar, Federica Anastasi, Olena Ohlei, Raquel Puerta Fuentes, Chenyu Yang, Joseph Bradley, Daniel Western, Muhammad Ali, Ciyang Wang, Chengran Yang, Ying Wu, Menghan Liu, John Budde, Julie Williams, Rebecca Mahoney, Atahualpa Castillo Morales, Timothy J Hohman, Logan Dumitrescu, Ting-Chen Wang, Niccolo' Tesi, Silke Kern, Margda Waern, Ingmar Skoog, Argonde van Harten, Yolande A L Pijnenburg, Wiesje M van der Flier, Pascual Sánchez-Juan, Eloy Rodriguez-Rodriguez, Luca Kleineidam, Oliver Peters, Anja Schneider, Fahri Küçükali, Céline Bellenguez, Benjamin Grenier-Boley, Sami Heikkinen, Itziar de Rojas, Dan Rujescu, Norbert Scherbaum, Lucrezia Hausner, Emrah Düzel, Timo Grimmer, Jens Wiltfang, Rik Vandenberghe, Sebastiaan Engelborghs, Stefanie Heilmann-Heimbach, Matthias Schmid, Thomas Tegos, Nikolaos Scarmeas, Oriol Dols-Icardo, Fermin Moreno, Jordi Pérez-Tur, María J Bullido, Raquel Sánchez-Valle, Victoria Álvarez, Pablo García-González, Pablo Mir, Luis M Real, Gerard Piñol-Ripoll, Jose María García-Alberca, Harro Seelaar, Inez Ramakers, Janne Papma, Marc Hulsman, Christoph Laske, Stefan Teipel, Josef Priller, Robert Perneczky, Katharina Buerger, Markus M Nöthen, Piotr Lewczuk, Johannes Kornhuber, Harald Hampel, Ina Giegling, Oliver Goldhardt, Janine Diehl-Schmid, Victor Andrade, Michael Mt Heneka, Lutz Frölich, Jonathan Vogelgsang, Caroline Graff, Hakan Thonberg, Abbe Ullgren, Goran Papenberg, Jean-François Deleuze, Carole Dufouil, Michael Wagner, Frank Jessen, Henne Holstege, Cornelia van Duijn, Thibaud Lebouvier, Olivier Hannon, Ville Leinonen, Hilkka Soininen, Sanna-Kaisa Herukka, Vilmantas Giedraitis, Malin Löwenmark, Lena Kilander, Patricia Genius, Blanca Rodríguez, Emma S Luckett, Arcadi Navarro, Amanda Cano, Marta Marquié, Kaj Blennow, Henrik Zetterberg, Alberto Lleo, Mercè Boada, Agustin Ruiz, Virginia Man-Yee Lee, Vivianna M Van Deerlin, Yuetiva Deming, Sterling C Johnson, Corinne D Engelman, Pau Pastor, Ignacio Alvarez, Elaine R Peskind, Amanda J Heslegrave, Andrew J Saykin, Kwangsik Nho, Suzanne E Schindler, John C Morris, David M Holtzman, Eric McDade, Alan E Renton, Alison Goate, Laura Ibanez, Matthias Riemenschneider, Marilyn S Albert, Simon M Laws, Tenielle Porter, Eleanor K O'Brien, Leslie M Shaw, Betty M Tijms, Martin Ingelsson, Pieter Jelle Visser, Mikko Hiltunen, Kristel Sleegers, Craig W Ritchie, Rebecca Sims, Michael Belloy, Jean-Charles Lambert, Natalia Vilor-Tejedor, Maria Victoria Fernández, Qingqin S Li, Michael W Nagle, Riccardo E Marioni, Alfredo Ramirez, Lars Bertram, Sven J van der Lee, Carlos Cruchaga
Dysfunction of the episodic memory network in the Alzheimer's disease cascade.
Nature communications
Authors:
René Lattmann, Niklas Vockert, Jose Bernal, Judith Wesenberg, Yanin Suksangkharn, Renat Yakupov, Hartmut Schütze, Wenzel Glanz, Enise Incesoy, Michaela Butryn, Falk Lüsebrink, Matthias Schmid, Melina Stark, Luca Kleineidam, Annika Spottke, Marie Coenjaerts, Frederic Brosseron, Klaus Fliessbach, Anja Schneider, Peter Dechent, Klaus Scheffler, Stefan Hetzer, Alfredo Ramirez, Christoph Laske, Sebastian Sodenkamp, Slawek Altenstein, Luisa-Sophie Schneider, Daria Gref, Eike Jakob Spruth, Andrea Lohse, Björn H Schott, Jens Wiltfang, Ingo Kilimann, Doreen Goerss, Ayda Rostamzadeh, Josef Priller, Oliver Peters, Julian Hellmann-Regen, Stefan Teipel, Michael Wagner, Frank Jessen, Anne Maass, Gabriel Ziegler, Emrah Düzel
