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Prof. Dr. Alfredo Ramirez

Member

Department of Psychiatry and Psychotherapy, University of Cologne

Kerpener Str. 62, 50931 Cologne

alfredo.ramirez@uk-koeln.de

The main objective of Dr. Ramirez’s laboratory is the identification of the genetic and epigenetic architecture that influences the disease processes underlying cognitive disorders such as Alzheimer’s disease. A key focus of his research is identifying the molecular mechanisms at the intersection of ageing and Alzheimer’s disease that drive cognitive decline. His group combines (epi)genomics and proteomics to study cellular senescence, a key mechanism that triggers chronic inflammation through the senescence-associated secretory phenotype (SASP).

Prof. Dr. Alfredo Ramirez

Recent publications

  • Enhancing Tyro3 signalling ameliorates IL-1β production through STAT1 in Alzheimer's disease models.

    Journal of leukocyte biology

    Authors: Kishore Aravind Ravichandran, Frederic Brosseron, Róisín M McManus, Christina Ising, Simon Görgen, Susanne Schmidt, Fracesco Santarelli, Se Young Lee, Hyuncheol Jung, Won-Suk Chung, Chan Hyuk Kim, Agustin Ruiz Laza, Carmen Ruiz de Almodóvar, Alfredo Ramirez, Eicke Latz, Michael T Heneka

  • Replication of blood DNA methylomic signatures associated with cerebrospinal fluid levels of YKL-40 and NfL biomarkers.

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    Authors: Timo Kaleck, Rafael Campos-Martin, Amanda Cano, Maria Victoria Fernández, Pamela Martino-Adami, Luca Kleineidam, Victor M Andrade Fuentes, Kumar P Tripathi, Kayenat Parveen, Raquel Puerta, Itziar de Rojas, Kishore A Ravichandran, Oliver Peters, Julian Hellmann-Regen, Josef Priller, Maria Gemenetzi, Anja Schneider, Jens Wiltfang, Emrah Düzel, Katharina Buerger, Robert Perneczky, Stefan Teipel, Christoph Laske, Frederic Brosseron, Marta Marquié, Daniel LA van den Hove, Mercè Boada, Michael T Heneka, Michael Wagner, Natalie Marchant, Jean-Charles Lambert, Ruth Frikke-Schmidt, Frank Jessen, Agustín Ruiz, Alfredo Ramirez

  • Disease stage-specific atrophy markers in Alzheimer's disease.

    medRxiv : the preprint server for health sciences

    Authors: Hannah Baumeister, Helena M Gellersen, Sarah E Polk, René Lattmann, Anika Wuestefeld, Laura E M Wisse, Trevor Glenn, Renat Yakupov, Melina Stark, Luca Kleineidam, Sandra Roeske, Barbara Marcos Morgado, Hermann Esselmann, Frederic Brosseron, Alfredo Ramirez, Falk Lüsebrink, Matthis Synofzik, Björn H Schott, Matthias C Schmid, Stefan Hetzer, Peter Dechent, Klaus Scheffler, Michael Ewers, Julian Hellmann-Regen, Ersin Ersözlü, Eike Spruth, Maria Gemenetzi, Klaus Fliessbach, Claudia Bartels, Ayda Rostamzadeh, Wenzel Glanz, Enise I Incesoy, Daniel Janowitz, Boris-Stephan Rauchmann, Ingo Kilimann, Sebastian Sodenkamp, Marie Coenjaerts, Annika Spottke, Oliver Peters, Josef Priller, Anja Schneider, Jens Wiltfang, Katharina Buerger, Robert Perneczky, Stefan Teipel, Christoph Laske, Michael Wagner, Gabriel Ziegler, Frank Jessen, Emrah Düzel, David Berron

All publications by Prof. Dr. Alfredo Ramirez