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Prof. Dr. Annkristin Heine


Institute of Experimental Immunology (IEI) & Medical Clinic III

Medical Faculty, University of Bonn University Hospital of Bonn Venusberg - Campus 1 53127 Bonn


Dr. Heine and her group are interested in the mechanisms governing antigen cross-presentation and cytotoxic T cell induction in the context of anti-tumor immune responses. Effective cancer vaccines should not only induce strong and durable T cell responses, but also optimally modulate the balance between suppressive and stimulatory factors in the tumor microenvironment. The aim of her research is the identification of novel immunotherapeutic strategies that accomplish both, with a special focus on different pathways of dendritic cell licensing and chemokine receptor modulation.

Recent publications

  • Early combination therapy of COVID-19 in high-risk patients.


    Authors: Hans Martin Orth, Charlotte Flasshove, Moritz Berger, Sandra Tessa Hattenhauer, Kaja D Biederbick, Rebekka Mispelbaum, Uwe Klein, Jannik Stemler, Matthis Fisahn, Anna D Doleschall, Ben-Niklas Baermann, Eva Koenigshausen, Olga Tselikmann, Alexander Killer, Clara de Angelis, Smaranda Gliga, Johannes Stegbauer, Nikolai Spuck, Gerda Silling, Jürgen K Rockstroh, Christian P Strassburg, Peter Brossart, Jens P Panse, Björn-Erik Ole Jensen, Tom Luedde, Christoph Boesecke, Annkristin Heine, Oliver A Cornely, Malte B Monin

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  • Spoilt for choice: different immunosuppressive potential of anaplastic lymphoma kinase inhibitors for non small cell lung cancer.

    Frontiers in immunology

    Authors: Annkristin Heine, Stefanie Andrea Erika Held, Solveig Nora Daecke, Chrystel Flores, Peter Brossart

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  • Optimized Conformal Total Body Irradiation with VMAT Using a Linear-Accelerator-Based Radiosurgery Treatment System in Comparison to the Golden Standard Helical TomoTherapy.


    Authors: Mümtaz Köksal, Oğuzhan Özkan, Tobias Holderried, Annkristin Heine, Peter Brossart, Ahmed Gawish, Davide Scafa, Gustavo R Sarria, Christina Leitzen, Leonard C Schmeel, Thomas Müdder

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