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Prof. Dr. Annkristin Heine


Institute of Experimental Immunology (IEI) & Medical Clinic III

Medical Faculty, University of Bonn University Hospital of Bonn Venusberg - Campus 1 53127 Bonn


Dr. Heine and her group are interested in the mechanisms governing antigen cross-presentation and cytotoxic T cell induction in the context of anti-tumor immune responses. Effective cancer vaccines should not only induce strong and durable T cell responses, but also optimally modulate the balance between suppressive and stimulatory factors in the tumor microenvironment. The aim of her research is the identification of novel immunotherapeutic strategies that accomplish both, with a special focus on different pathways of dendritic cell licensing and chemokine receptor modulation.

Recent publications

  • Severe autoimmune hemolytic anemia following immunotherapy with checkpoint inhibitors in two patients with metastatic melanoma: a case report.

    Frontiers in immunology

    Authors: Tanja Fetter, Simon Fietz, Maya Bertlich, Christine Braegelmann, Luka de Vos-Hillebrand, Joerg Wenzel, Annkristin Heine, Jennifer Landsberg, Philipp Jansen

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  • Intramedullary leukocytoclastic vasculitis and neutrophil extracellular trap (NET) formation in POEMS syndrome.

    Annals of hematology

    Authors: Wiebke Aderhold, Benjamin Lenz, Marc P Hübner, Hans-Eckart Schaefer, Florian C Gaertner, Annkristin Heine, Ines Gütgemann

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  • Rapid protection against viral infections by chemokine-accelerated post-exposure vaccination.

    Frontiers in immunology

    Authors: Annkristin Heine, Niels A W Lemmermann, Chrystel Flores, Janine Becker-Gotot, Natalio Garbi, Peter Brossart, Christian Kurts

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