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Prof. Dr. Axel Kallies

Member

Institute of Molecular Medicine and Experimental Immunology (IMMEI)

Venusberg-Campus 1, 53127 Bonn

axel.kallies@unimelb.edu.au

The research of the Kallies lab focusses on T cell differentiation and function in viral infection, cancer and metabolic disease. Specifically, we aim to understand the molecular regulation of cytotoxic CD8 T cells, conventional CD4 T cells and regulatory T cells with a focus on stem-like and tissue-resident cells in chronic disease. We make extensive use of preclinical models and cutting-edge technology such as single cell RNA sequencing and epigenetic profiling.

Prof. Dr. Axel Kallies

Recent publications

  • Pregnancy-induced tissue-resident memory-like T cells contribute to tumor control in breast cancer.

    Nature immunology

    Authors: Tabinda Hussain, Melrine Pereira, David Chisanga, Caleb A Dawson, Adelynn Tang, Pathum Thilakasiri, Jayendra Singh, Meagan Ruppert, Ashleigh Davey, Kevin Man, Patrizia Murer, Liam Neil, Conor McGuinness, Yuxi Cao, Chun-Hsi Su, Rebecca Nightingale, Katie Gdak, Genevieve Mason, Damien Grinsell, Hamish Farrow, Natalie Ngan, Stephanie Liong, Jian Wu, Sarah McLucas, Pepper Schedin, Arttu Junnila, Matti Poutanen, Nicole M Haynes, Nicholas D Huntington, Michael Chopin, Thomas Gebhardt, Bhupinder Pal, Daniel T Utzschneider, John M Mariadason, Axel Kallies, Kara L Britt, Ajithkumar Vasanthakumar

  • B cell-derived type I interferon sustains T cell functionality upon strong TCR stimulation during chronic infection.

    Immunity

    Authors: Catarina Gago da Graça, Yuxi Cao, Sining Li, Anna F Lindemann, Leonie Heyden, Sharanya K M Wijesinghe, Annika Poch, Minh-Hanh T Nguyen, Nhat T Huynh-Anh, Elena Daum, Danielle Chen, Carlson Tsui, Erandi Rupasinghe, Michael P Gantier, Axel Roers, Robert Thimme, Maike Hofmann, Sammy Bedoui, Zeinab Abdullah, Jan Schröder, Axel Kallies, Yannick O Alexandre, Daniel T Utzschneider

  • New insights into progenitor exhausted T cell populations.

    Nature reviews. Immunology

    Authors: Rafi Ahmed, Maike Hofmann, Axel Kallies, Annette Oxenius, Mary Philip, E John Wherry, Lilin Ye, Dietmar Zehn

All publications by Prof. Dr. Axel Kallies