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Prof. Dr. Axel Kallies

Member

Institute of Molecular Medicine and Experimental Immunology (IMMEI)

Venusberg-Campus 1, 53127 Bonn

axel.kallies@unimelb.edu.au

The research of the Kallies lab focusses on T cell differentiation and function in viral infection, cancer and metabolic disease. Specifically, we aim to understand the molecular regulation of cytotoxic CD8 T cells, conventional CD4 T cells and regulatory T cells with a focus on stem-like and tissue-resident cells in chronic disease. We make extensive use of preclinical models and cutting-edge technology such as single cell RNA sequencing and epigenetic profiling.

Prof. Dr. Axel Kallies

Recent publications

  • Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine.

    Science immunology

    Authors: Kevin Man, Vinicius A Duarte da Silva, Nikita Potemkin, Sarah S Gabriel, Teisha Mason, Tarek Elmzzahi, Marcela De Lima Moreira, Chun-Hsi Su, Laura Mackay, Marc D Beyer, Jan Schröder, Georg Gasteiger, Axel Kallies

  • Transcriptional regulator SATB1 limits CD8 T cell population expansion and effector differentiation in chronic infection and cancer.

    Nature immunology

    Authors: Leonie Heyden, Lisa Rausch, Michael H Shannon, Lachlan Dryburgh, Marcela L Moreira, Aleksej Frolov, Christina M Scheffler, Marit J van Elsas, Junming Tong, Olivia Hidajat, Sharanya K M Wijesinghe, Sining Li, Helena Horvatic, Nhat Truong Huynh-Anh, Catarina Gago da Graça, Carlson Tsui, Maren Köhne, Daniel Sommer, F Thomas Wunderlich, Bianca von Scheidt, Simone L Park, Laura K Mackay, Daniel T Utzschneider, Jan Schröder, Stephen J Turner, Phillip K Darcy, Marc D Beyer, Zeinab Abdullah, Axel Kallies

  • The co-inhibitory receptor TIGIT promotes tissue-protective functions in T cells.

    Nature immunology

    Authors: Camilla Panetti, Rahel Daetwyler, Anja Moncsek, Nikolaos Patikas, Andreas Agrafiotis, Adelynn Tang, Francesco Andreata, Valeria Fumagalli, Jean De Lima, Lifen Wen, Carolyn G King, Ajithkumar Vasanthakumar, Matteo Iannacone, Axel Kallies, Alexander Yermanos, Martin Hemberg, Nicole Joller

All publications by Prof. Dr. Axel Kallies