Skip to main content

Prof. Dr. Axel Kallies

Member

Institute of Molecular Medicine and Experimental Immunology (IMMEI)

Venusberg-Campus 1, 53127 Bonn

axel.kallies@unimelb.edu.au

The research of the Kallies lab focusses on T cell differentiation and function in viral infection, cancer and metabolic disease. Specifically, we aim to understand the molecular regulation of cytotoxic CD8 T cells, conventional CD4 T cells and regulatory T cells with a focus on stem-like and tissue-resident cells in chronic disease. We make extensive use of preclinical models and cutting-edge technology such as single cell RNA sequencing and epigenetic profiling.

Prof. Dr. Axel Kallies

Recent publications

  • The co-inhibitory receptor TIGIT promotes tissue-protective functions in T cells.

    Nature immunology

    Authors: Camilla Panetti, Rahel Daetwyler, Anja Moncsek, Nikolaos Patikas, Andreas Agrafiotis, Adelynn Tang, Francesco Andreata, Valeria Fumagalli, Jean De Lima, Lifen Wen, Carolyn G King, Ajithkumar Vasanthakumar, Matteo Iannacone, Axel Kallies, Alexander Yermanos, Martin Hemberg, Nicole Joller

  • Lymph nodes fuel KLF2-dependent effector CD8 T cell differentiation during chronic infection and checkpoint blockade.

    Nature immunology

    Authors: Carlson Tsui, Leonie Heyden, Lifen Wen, Catarina Gago da Graça, Nikita Potemkin, Aleksej Frolov, Daniel Rawlinson, Lei Qin, Verena C Wimmer, Marjan Hadian-Jazi, Darya Malko, Chun-Hsi Su, Sining Li, Kayla R Wilson, Helena Horvatic, Sharanya K Wijesinghe, Marcela L Moreira, Lachlan Dryburgh, Dominik Schienstock, Lisa Rausch, Daniel T Utzschneider, Cornelia Halin, Scott N Mueller, Marc D Beyer, Sammy Bedoui, Zeinab Abdullah, Jan Schröder, Axel Kallies

All publications by Prof. Dr. Axel Kallies