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Prof. Dr. Carmen Ruiz de Almodóvar

Member

Institute of Neurovascular Cell Biology

Life & Brain Center (Geb. 76) Venusberg-Campus 1

carmen.ruizdealmodovar@ukbonn.de

Website

The main research focus of our institute is the study of the vasculature and its properties within the central nervous system. We are interested in understanding how blood vessels grow in the CNS, as well as how they interact with other cells of the CNS to form the neurovascular unit. Recent research demonstrates that blood vessels are not just passive tubes that deliver oxygen and nutrients but that, via active signaling, they also control organ development and function. We focus on this concept to identify the mechanisms of vascular cells-derived signals could modulate neural network formation and function, and how vascular dysfunction could contribute to different neurological diseases. Understanding the interaction of vascular cells with cells of the oligodendrocyte lineage and with microglia are new aims that we are starting to develop and which we aim to re-inforce here in Bonn.

For this we combine mouse genetic, ex-organotypic cultures, primary cell cultures, tissue clearing and high resolution imaging, and state of the art biochemical and molecular biology techniques.

Carmen Ruiz de Almodovar

Recent publications

  • IRF7 signalling in tanycytes controls brain-body-immune response across the ovarian cycle.

    Nature metabolism

    Authors: Sreekala Nampoothiri, Daniela Fernandois, Nathalie Journiac, Fabien Delahaye, Yvon Mbouamboua, Florent Sauve, Marie Couralet, Sarah Gallet, Naziha Mroueh, Maria Laura Serradas Aponte, Nathalie Jouy, Rachel Spenle, Ruth Schmidt-Ullrich, Ines Martinez Corral, Virginie Mattot, Carmen Ruiz de Almodovar, Andreas Schlitzer, Philippe Froguel, Claude-Alain Maurage, Pascal Barbry, Paolo Giacobini, Lennart T Mars, Amelie Bonnefond, Ruben Nogueiras, Markus Schwaninger, Vincent Prevot

  • Retinal ganglion cell survival and functional maturation in transiently vascularized human retinal organoids.

    Cell stem cell

    Authors: Kritika Sharma, Rouhollah Habibey, Mariana M Ribeiro, Bohao Cui, Rebecca A Siwicki, Johannes Striebel, Julia S Pawlick, Jasmin Zorn, Larissa Utz, Magdalena Renner, Simone Picelli, Frank G Holz, Carmen Ruiz de Almodóvar, Cameron S Cowan, Volker Busskamp

  • Neurovascular dynamics in the spinal cord from development to pathophysiology.

    Neuron

    Authors: Carmen Ruiz de Almodovar, Sebastian Dupraz, Dario Bonanomi

All publications by Prof. Dr. Carmen Ruiz de Almodóvar