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Prof. Dr. Carmen Ruiz de Almodóvar

Member

Institute of Neurovascular Cell Biology

Life & Brain Center (Geb. 76) Venusberg-Campus 1

carmen.ruizdealmodovar@ukbonn.de

Website

The main research focus of our institute is the study of the vasculature and its properties within the central nervous system. We are interested in understanding how blood vessels grow in the CNS, as well as how they interact with other cells of the CNS to form the neurovascular unit. Recent research demonstrates that blood vessels are not just passive tubes that deliver oxygen and nutrients but that, via active signaling, they also control organ development and function. We focus on this concept to identify the mechanisms of vascular cells-derived signals could modulate neural network formation and function, and how vascular dysfunction could contribute to different neurological diseases. Understanding the interaction of vascular cells with cells of the oligodendrocyte lineage and with microglia are new aims that we are starting to develop and which we aim to re-inforce here in Bonn.

For this we combine mouse genetic, ex-organotypic cultures, primary cell cultures, tissue clearing and high resolution imaging, and state of the art biochemical and molecular biology techniques.

Carmen Ruiz de Almodovar

Recent publications

  • Endolysosomal dysfunction in radial glia progenitor cells leads to defective cerebral angiogenesis and compromised blood-brain barrier integrity.

    Nature communications

    Authors: Ivan Bassi, Moshe Grunspan, Gideon Hen, Kishore A Ravichandran, Noga Moshe, Laura Gutierrez-Miranda, Stav R Safriel, Daria Kostina, Amitay Shen, Carmen Ruiz de Almodovar, Karina Yaniv

  • The vasculature of neurogenic niches: Properties and function.

    Cells & development

    Authors: Andromachi Karakatsani, María I Álvarez-Vergara, Carmen Ruiz de Almodóvar

  • Top publication

    Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development.

    Neuron

    Authors: José Ricardo Vieira, Bhavin Shah, Sebastian Dupraz, Isidora Paredes, Patricia Himmels, Géza Schermann, Heike Adler, Alessia Motta, Lea Gärtner, Ariadna Navarro-Aragall, Elena Ioannou, Elena Dyukova, Remy Bonnavion, Andreas Fischer, Dario Bonanomi, Frank Bradke, Christiana Ruhrberg, Carmen Ruiz de Almodóvar

All publications by Prof. Dr. Carmen Ruiz de Almodóvar