Retinoic acid drives intestine-specific adaptation of effector ILC2s originating from distant sites.
The Journal of experimental medicine
View this publicationMember, Steering-Committee Member
Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53127 Bonn
The research team of Prof. Christoph Wilhelm studies the metabolic control of mucosal immune cells to better understand what distinguishes their protective function in infection from immune-mediated pathology and chronic inflammation. Specifically, we aim to untangle how dietary restriction and fasting affect the immune system and how exogenous and endogenous metabolites influence barrier immune cell function. We have found that a ketogenic diet can be used as an effective dietary intervention strategy for the treatment of chronic airway inflammation and that ketogenesis triggered by severe respiratory infections supports T cell function by providing ketone bodies as an alternative carbon source. Our central goal is to understand the link between Westernization and the growing health problem of chronic inflammation, as well as the increased susceptibility to infections in people with metabolic diseases.
The Journal of experimental medicine
View this publicationJournal of clinical medicine
View this publicationThe Journal of infectious diseases
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