Retinoic acid and TGF-β orchestrate organ-specific programs of tissue residency.
Immunity
View this publicationMember, Steering-Committee Member
Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53127 Bonn
The research team of Prof. Christoph Wilhelm studies the metabolic control of mucosal immune cells to better understand what distinguishes their protective function in infection from immune-mediated pathology and chronic inflammation. Specifically, we aim to untangle how dietary restriction and fasting affect the immune system and how exogenous and endogenous metabolites influence barrier immune cell function. We have found that a ketogenic diet can be used as an effective dietary intervention strategy for the treatment of chronic airway inflammation and that ketogenesis triggered by severe respiratory infections supports T cell function by providing ketone bodies as an alternative carbon source. Our central goal is to understand the link between Westernization and the growing health problem of chronic inflammation, as well as the increased susceptibility to infections in people with metabolic diseases.
Immunity
View this publicationRedox biology
View this publicationJournal of the American Chemical Society
View this publication