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Prof. Dr. Katrin Paeschke

Member

Institute of Clinical Chemistry & Clinical Pharmacology

Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53105 Bonn

katrin.paeschke@ukbonn.de

Website

Katrin Paeschke's research focuses on specific DNA and RNA structures named G-quadruplexes (G4s). These structures form within all living cells including virus where they support cellular functions. The Paeschke group aims to characterise how DNA and RNA G-quadruplex structures are recognised and regulated by proteins.We utilise a combination of molecular, biochemical and global experimental approaches (ChIP-seq, ATAC-seq, Cut & Tag, RNA-seq, PAR-CLIP) to better understand the molecular network and contribution of G4s for genome stability and cellular functions in living cells. We also aim to characterise how G4-protein interactions (both on DNA and RNA levels) contribute to the immune response activation and how these structures can modulate the immune response.

Katrin Paeschke

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Recent publications

  • DHX36 is a regulatory switch in the interferon-mediated antiviral response.

    Science advances

    Authors: Lisa Weixler, Daniel Hilbig, Philipp S Simon, Stefan Juranek, Julia Mahlberg, Martin Schlee, Eva Bartok, Markus Hafner, Katrin Paeschke

  • The Zuo1 C-terminal domain stabilizes DNA guanosine quadruplex (G4) structures located on Chromosome IX in Saccharomyces cerevisiae.

    Nucleic acids research

    Authors: Ines Burkhart, Michaela Limmer, J Carlos Penedo, Li-Chia Sauer, Harald Schwalbe, Katrin Paeschke

  • Poly (ADP-ribose) polymerase in yeasts: characterization and involvement in telomere maintenance.

    Nucleic acids research

    Authors: Regina Sepšiová, Katarína Procházková, Filip Červenák, Denis Majerčík, Kateřina Hanáková, Erika Lattová, Mona Hajikazemi, Zbyněk Zdráhal, Sofia Virágová, Zuzana Brzáčová, Katrin Paeschke, Jozef Nosek, Ľubomír Tomáška

All publications by Prof. Dr. Katrin Paeschke