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TGF-β specifies T versus T17 cell fates in murine CD4 T cells through c-Maf.
Science immunology
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Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53105 Bonn
Katrin Paeschke's research focuses on specific DNA and RNA structures named G-quadruplexes (G4s). These structures form within all living cells including virus where they support cellular functions. The Paeschke group aims to characterise how DNA and RNA G-quadruplex structures are recognised and regulated by proteins.We utilise a combination of molecular, biochemical and global experimental approaches (ChIP-seq, ATAC-seq, Cut & Tag, RNA-seq, PAR-CLIP) to better understand the molecular network and contribution of G4s for genome stability and cellular functions in living cells. We also aim to characterise how G4-protein interactions (both on DNA and RNA levels) contribute to the immune response activation and how these structures can modulate the immune response.
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Science immunology
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Nature communications
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