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Prof. Dr. Katrin Paeschke

Member, Steering-Committee Member

Institute of Clinical Chemistry & Clinical Pharmacology

Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53105 Bonn


Katrin Paeschke's research focuses on specific DNA and RNA structures named G-quadruplexes (G4s). These structures form within all living cells including virus where they support cellular functions. The Paeschke group aims to characterise how DNA and RNA G-quadruplex structures are recognised and regulated by proteins.We utilise a combination of molecular, biochemical and global experimental approaches (ChIP-seq, ATAC-seq, Cut & Tag, RNA-seq, PAR-CLIP) to better understand the molecular network and contribution of G4s for genome stability and cellular functions in living cells. We also aim to characterise how G4-protein interactions (both on DNA and RNA levels) contribute to the immune response activation and how these structures can modulate the immune response.

Recent publications

  • Hemocyte Nuclei Isolation from Adult Drosophila melanogaster for snRNA-seq.

    Methods in molecular biology (Clifton, N.J.)

    Authors: Fabian Hersperger, Melanie Kastl, Katrin Paeschke, Katrin Kierdorf

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  • Detection of G-Quadruplex DNA Structures in Macrophages.

    Methods in molecular biology (Clifton, N.J.)

    Authors: Melanie Kastl, Fabian Hersperger, Katrin Kierdorf, Katrin Paeschke

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  • RNA-DNA hybrids prevent resection at dysfunctional telomeres.

    Cell reports

    Authors: Vanessa Borges Pires, Nina Lohner, Tina Wagner, Carolin B Wagner, Maya Wilkens, Mona Hajikazemi, Katrin Paeschke, Falk Butter, Brian Luke

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