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Prof. Dr. Katrin Paeschke

Member

Institute of Clinical Chemistry & Clinical Pharmacology

Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53105 Bonn

katrin.paeschke@ukbonn.de

Website

Katrin Paeschke's research focuses on specific DNA and RNA structures named G-quadruplexes (G4s). These structures form within all living cells including virus where they support cellular functions. The Paeschke group aims to characterise how DNA and RNA G-quadruplex structures are recognised and regulated by proteins.We utilise a combination of molecular, biochemical and global experimental approaches (ChIP-seq, ATAC-seq, Cut & Tag, RNA-seq, PAR-CLIP) to better understand the molecular network and contribution of G4s for genome stability and cellular functions in living cells. We also aim to characterise how G4-protein interactions (both on DNA and RNA levels) contribute to the immune response activation and how these structures can modulate the immune response.

Katrin Paeschke

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Recent publications

  • Taking damage as an advantage: Adaptation of Drosophila hemocyte functions upon DNA damage.

    Developmental biology

    Authors: Lena Neuhaus, Monica Rodriguez Nava, Katrin Paeschke, Katrin Kierdorf

  • DHX36 is a regulatory switch in the interferon-mediated antiviral response.

    Science advances

    Authors: Lisa Weixler, Daniel Hilbig, Philipp S Simon, Stefan Juranek, Julia Mahlberg, Martin Schlee, Eva Bartok, Markus Hafner, Katrin Paeschke

  • The Zuo1 C-terminal domain stabilizes DNA guanosine quadruplex (G4) structures located on Chromosome IX in Saccharomyces cerevisiae.

    Nucleic acids research

    Authors: Ines Burkhart, Michaela Limmer, J Carlos Penedo, Li-Chia Sauer, Harald Schwalbe, Katrin Paeschke

All publications by Prof. Dr. Katrin Paeschke