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Prof. Dr. med. Achim Hörauf

Member, Steering-Committee Member

Medical Microbiology, Immunology and Parasitology

Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53127 Bonn

achim.hoerauf@ukbonn.de

Website

Prof. Hörauf is internationally renowned for his work in Tropical Medicine, in particular for pioneering new drug treatments against filariasis (a group of neglected tropical diseases). The new treatment exploits an endosymbiosis between worms and bacterial endosymbionts called Wolbachia, which are susceptible to some classes of antibiotics. Prof. Hörauf’s group was the first to characterize a TLR2 ligand from Wolbachia and established that blindness in onchocerciasis (or ‘river blindness’) is dependent on innate immune reactions against Wolbachia. They were the first to detect regulatory T cells in humans in an infection. Modulation of host’s immune responses is another focus of Prof. Hörauf’s group, demonstrating that filarial infection and filarial antigen treatment protects against type 1 diabetes onset and improves glucose tolerance during obesity. Using expression quantitative trait loci analysis, the role of genetic factors in modulating cellular responses (to filarial antigens) and eventually filariae-caused pathology devel-opment is currently investigated. Beyond immunology, Achim Hoerauf has preclinically developed 4 new drugs against human filariasis which are now in clinical phase 1 and 2 studies, together with DNDi and pharma partners such as Abbvie, Bayer, and Esai.

Recent publications

  • Mesoporous Silica as an Alternative Vehicle to Overcome Solubility Limitations.

    Pharmaceutics

    Authors: Tim Becker, Jan Heitkötter, Anna K Krome, Andrea Schiefer, Kenneth Pfarr, Alexandra Ehrens, Miriam Grosse, Birthe Sandargo, Ingo Stammberger, Marc Stadler, Marc P Hübner, Stefan Kehraus, Achim Hoerauf, Karl G Wagner

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  • Repeated sensitization of mice with microfilariae of Litomosoides sigmodontis induces pulmonary eosinophilia in an IL-33-dependent manner.

    PLoS pathogens

    Authors: Benjamin Lenz, Alexandra Ehrens, Jesuthas Ajendra, Frederic Risch, Joséphine Gal, Anna-Lena Neumann, Julia J Reichwald, Wiebke Strutz, Henry J McSorley, Coralie Martin, Achim Hoerauf, Marc P Hübner

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  • Impact of repeated mass ivermectin administration using a community directed approach on . infection in of the rain forest and forest savanna of Cameroon.

    Parasite epidemiology and control

    Authors: Glory N Amambo, Fanny F Fombad, Patrick W Chounna Ndongmo, Raphael Awah Abong, Abdel Jelil Njouendou, Amuam Andrew Beng, Theobald Mue Nji, Mathias Eyong Esum, Jerome Fru-Cho, Ritter Manuel, Deribe Kebede, Peter Ivo Enyong, Achim Hoerauf, Benjamin Koudou, Moses Bockarie, Samuel Wanji

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