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Prof. Dr. med. Achim Hörauf

Member, Steering-Committee Member

Medical Microbiology, Immunology and Parasitology

Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53127 Bonn

achim.hoerauf@ukbonn.de

Website

Prof. Hörauf is internationally renowned for his work in Tropical Medicine, in particular for pioneering new drug treatments against filariasis (a group of neglected tropical diseases). The new treatment exploits an endosymbiosis between worms and bacterial endosymbionts called Wolbachia, which are susceptible to some classes of antibiotics. Prof. Hörauf’s group was the first to characterize a TLR2 ligand from Wolbachia and established that blindness in onchocerciasis (or ‘river blindness’) is dependent on innate immune reactions against Wolbachia. They were the first to detect regulatory T cells in humans in an infection. Modulation of host’s immune responses is another focus of Prof. Hörauf’s group, demonstrating that filarial infection and filarial antigen treatment protects against type 1 diabetes onset and improves glucose tolerance during obesity. Using expression quantitative trait loci analysis, the role of genetic factors in modulating cellular responses (to filarial antigens) and eventually filariae-caused pathology devel-opment is currently investigated. Beyond immunology, Achim Hoerauf has preclinically developed 4 new drugs against human filariasis which are now in clinical phase 1 and 2 studies, together with DNDi and pharma partners such as Abbvie, Bayer, and Esai.

Recent publications

  • The pipeline for drugs for control and elimination of neglected tropical diseases: 2. Oral anti-infective drugs and drug combinations for off-label use.

    Parasites & vectors

    Authors: Kenneth M Pfarr, Anna K Krome, Issraa Al-Obaidi, Hannah Batchelor, Michel Vaillant, Achim Hoerauf, Nicholas O Opoku, Annette C Kuesel

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  • Gastrointestinal Pathogens in Multi-Infected Individuals: A Cluster Analysis of Interaction.

    Microorganisms

    Authors: Joy Backhaus, Hagen Frickmann, Ralf Matthias Hagen, Gustavo Concha, Ernst Molitor, Achim Hoerauf, Simone Kann

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  • First case of Dirofilaria hongkongensis infection in Germany presenting as a breast tumour.

    Journal of travel medicine

    Authors: Jakob Schroeder, Camilla Rothe, Achim Hoerauf, Inge Kroidl, Kenneth Pfarr, Marc P Hübner

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