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Prof. Dr. Regina Betz

Member, Steering-Committee Member

Institute of Human Genetics

Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53127 Bonn

regina.betz@uni-bonn.de

+49 228 28751023

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The aim of our research is the identification and functional characterization of genes for monogenic and genetically com-plex hair loss disorders with a major focus on the autoimmune disorder alopecia areata (AA). We have the largest sample of AA patients available worldwide, which includes a current total of more than 2.200 individuals of middle European origin. We have been able to demonstrate the contribution of the HLA-complex and the genes PTPN22, TRAF1/C5 , CTLA4, IL13 and KIAA0350 to the disease risk using candidate gene studies. By the use of genome-wide association studies, meta-analyses, immunochips and functional studies, we just recently identified HLA-DR as a key etiologic driver for AA as well as two loci outside the HLA-region: ACOXL/BCL2L11 and GARP. Future analyses and functional studies will contribute to a comprehensive understanding of AA.

Regina Betz

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Recent publications

  • Clinical Implications of Genetic Discoveries on Frontal Fibrosing Alopecia.

    JAMA dermatology

    Authors: F Buket Basmanav, Young-Ae Lee, Regina C Betz

  • Comorbid Bronchial Asthma, Atopic Dermatitis and Hashimoto's Thyroiditis Are Risk Factors for Early-Onset, Severe and Prolonged Alopecia Areata.

    Allergy

    Authors: Annika Friedrich, Marie-Therese Schmitz, Yasmina Gossmann, Silke Redler, Bettina Blaumeiser, Gerhard Lutz, Ulrike Blume-Peytavi, Markus M Nöthen, Regina C Betz, F Buket Basmanav

  • Proposing GLMN, encoding glomulin, as a novel gene for Dowling-Degos disease.

    The British journal of dermatology

    Authors: Sheetal Kumar, Regina C Betz, Jorge Frank

All publications by Prof. Dr. Regina Betz