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Prof. Dr. Winfried Barchet


Institute of Clinical Chemistry & Clinical Pharmacology

Medical Faculty, University of Bonn University Hospital of Bonn Sigmund-Freud-Strasse 25 53127 Bonn


The Barchet group focuses on the innate immune sensing of nucleic acids in scenarios ranging from pathogen infection, to cellular distress and autoinflammation. We study how and when distinct immune active structures are generated, gain access to receptors and are disposed of; and what mechanisms regulate the sensitivity of nucleic acid sensing pathways in sentinel cell-types, with the ultimate goal of informing appropriate immune therapeutic interventions.

Recent publications

  • U-DCS: characterization of the first permanent human dendritic sarcoma cell line.

    Scientific reports

    Authors: Kevin Mellert, Julian Benckendorff, Frank Leithäuser, Katarzyna Zimmermann, Peter Wiegand, Giada Frascaroli, Michaela Buck, Muriel Malaise, Gunther Hartmann, Winfried Barchet, Daniel Fürst, Joannis Mytilineos, Regine Mayer-Steinacker, Andreas Viardot, Peter Möller

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  • Absence of cGAS-mediated type I IFN responses in HIV-1-infected T cells.

    Proceedings of the National Academy of Sciences of the United States of America

    Authors: Carina Elsner, Aparna Ponnurangam, Julia Kazmierski, Thomas Zillinger, Jenny Jansen, Daniel Todt, Katinka Döhner, Shuting Xu, Aurélie Ducroux, Nils Kriedemann, Angelina Malassa, Pia-Katharina Larsen, Gunther Hartmann, Winfried Barchet, Eike Steinmann, Ulrich Kalinke, Beate Sodeik, Christine Goffinet

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  • Publication categories: Top publication

    Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2.


    Authors: Thomas Ostendorf, Thomas Zillinger, Katarzyna Andryka, Thais Marina Schlee-Guimaraes, Saskia Schmitz, Samira Marx, Kübra Bayrak, Rebecca Linke, Sarah Salgert, Julia Wegner, Tatjana Grasser, Sonja Bauersachs, Leon Soltesz, Marc P Hübner, Maximilian Nastaly, Christoph Coch, Matthias Kettwig, Ingo Roehl, Marco Henneke, Achim Hoerauf, Winfried Barchet, Jutta Gärtner, Martin Schlee, Gunther Hartmann, Eva Bartok

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